4S0H,2X6U,5BQD,5FLV


Conserved Protein Domain Family
T-box_TBX4_5-like

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cd20189: T-box_TBX4_5-like 
Click on image for an interactive view with Cn3D
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
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PSSM-Id: 410315
View PSSM: cd20189
Aligned: 20 rows
Threshold Bit Score: 372.92
Threshold Setting Gi: 1435095910
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA bindinghomodimerNKX2.5
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:TBX5 T-box monomers dimerize upon DNA binding, forming tight dimers; the dimer interface is on the opposite side of the DNA binding site
  • Structure:4S0H; Homo sapiens TBX5 monomer binds DNA, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##                                                   
4S0H_A         2 IKVFLHERELWLKFHEvGTEMIITKaGRRMFPSYKVKVTGLNPkTKYILLMDIVPADDHRYKFADNKWSVTGKAEPaMPG 81  human
CAE45765      96 VRVILQNKELWSKFHSvGTEMIITKaGRRMFPVIKVNISGLNPkLKYILVMDVVPVDDNRYKYHNSEWTVAGKAEPhLPG 175 Podocoryna carnea
ABL68081      72 VQVNLENKELWTKFHAlNTEMIITKtGRRMFPPIKIKLNGLNPnNKYIVLMDMVPADDHRYKYQNSEWVIAGKAEPtVPG 151 sea walnut
ABU50779      43 VKVELQDAGLWQRFHKaGTEMIITKaGRRMFPSIKVKVTGLQPkTKYIFVMDIVAVDSHRYKFNESKWSVAGKAEPaMPG 122 Florida lancelet
ADT64673      75 IKVVLHGRDLWAKFHKaTTEMIITKaGRRMFPVIKVSVAGLEPdAKYIIVMDVVPVGDNRYKFHDSEWVVTGKAEPtSAG 154 Ephydatia muelleri
ELT90467      15 IKINLENKELWQKFHAiGTEMIITKsGRRMFPTFKCSLEGLDPhAKYILLMDLVPLDDCRYKYHNSEWVVTGKAEPhMPG 94  Capitella teleta
XP_011680189 104 IKVTLEGRELWTKFHEiGTEMIITKaGRRMFPTFRCSITGLEQnAKYILLMDIVPVDDTRYKYHNSEWVVSGKAEPhMPS 183 purple sea urchin
KOG00847      80 IKIVLENRDLWQKFHTlGTEMIITKtGRRMFPTLKVSLEGLDPhTKYILLIDVLPVDDCRYKYHNSEWVVTGKAEPhMPG 159 Octopus bimacul...
XP_013379423  39 IKISLENRDLWEKFNSlGTEMIITKtGRRMFPTFKASLSGLDPhAKYILLVDIIPVDDCRYKYHNSEWVVTGKAEPhMPG 118 Lingula anatina
ROT71471     132 IKARLENENLWAQFDKfGTEMIITKlGRRMFPTVKMSASGLEPnTKYFVLMDIVPADDSRYKFQGKEWVVAGKAEPhMPG 211 Pacific white s...
Feature 1                                 #  #            ##                                     
4S0H_A        82 RLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPfGHIILNSMHKYQPRLHIVKadenng---fgsknTAFCTHVFPETA 158 human
CAE45765     176 RLYVHPDGPSTGAQWMRQTVSFQKVKLTNNHLDQfEHVILNSMHKYQPRIHIVQaddnsa---ealrkSTFTTHVFTETE 252 Podocoryna carnea
ABL68081     152 RMYIHPDSPATGLQWMKGPVTFHKMKLTNNTLDQqGHIILNSMHRYQPRIHVVEandik-----wlqfASLTTVSFPETV 226 sea walnut
ABU50779     123 RVFVHPDSPATGTHWMKQVVCFQKLKLTNNYMDTfGHIMLNSMHKYQPRLHIVQasennk---felkkTCFRTFIFPETE 199 Florida lancelet
ADT64673     155 RLYIHPDSPATGAVWEKQIISFQKLKITNNHLDQlGYIVLNSMHKFQPRIHVVKandekaitslqeggDSFSTHIFPETQ 234 Ephydatia muelleri
ELT90467      95 RLYIHPDSPASGSHWMKQPVSFHKLKLTNNNLDQnGHIILNSMHKYQPRIHVVQandif-----tmrwNSFNTYAFEETH 169 Capitella teleta
XP_011680189 184 RLYIHPDSPATGAVWMKQVVTFHKLKLTNNNLDQhGHIILNSMHKYQPRFHIVQandvf-----slrwNSFVTFAFPETT 258 purple sea urchin
KOG00847     160 RLYVHPDSPASGSHWMKQPVSFHKLKLTNNNLDQnGHIILNSMHKYQPRVHVVQandvf-----tmrwGSFYTYAFEETK 234 Octopus bimacul...
XP_013379423 119 RLYIHPDSPSSGAHWMKQSVSFHKLKLTNNNMDQnGHIILNSMHKYQPRVHVVQandif-----smrwTSFSTYSFEETT 193 Lingula anatina
ROT71471     212 RLYIHPDSPASGAQWMRHPISFQKLKLTNNNLDQqGHIILNSMHKYQPRIHIVAapdlv-----slhwAAFNTFAFPQTC 286 Pacific white s...
Feature 1            # #     #  ##  #######  
4S0H_A       159 FIAVTSYQNHKITQLKIENNPFAKGFRG 186 human
CAE45765     253 LIAVTAYQSPRITQLKIEDNPFAKGFRG 280 Podocoryna carnea
ABL68081     227 FMAVTAYQNDQITQLKIDHNPFAKGFRD 254 sea walnut
ABU50779     200 FMAVTSYQNHQITQLKIEHNPFAKGFRG 227 Florida lancelet
ADT64673     235 FMAVTAYQNQQITQLKIEHNPFAKGFRG 262 Ephydatia muelleri
ELT90467     170 FIAVTAYQNEQITQLKIDHNPFAKGFRD 197 Capitella teleta
XP_011680189 259 FIAVTAYQNEKITQLKIDHNPFAKGFRD 286 purple sea urchin
KOG00847     235 FIAVTAYQNEQITQLKIDNNPFAKGFRD 262 Octopus bimaculoides
XP_013379423 194 FIAVTAYQNEQITQLKIDNNPFAKGFRD 221 Lingula anatina
ROT71471     287 FMAVTAYQNERITQLKIDNNPFAKGFRE 314 Pacific white shrimp

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