Conserved Protein Domain Family
FXYD8
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cd20327: FXYD8 
FXYD domain-containing ion transport regulator 8
FXYD domain-containing ion transport regulator 8 (FXYD8), also known as FXYD domain containing ion transport regulator 6 pseudogene 3 (FXYD6P3), is a member of the FXYD protein family that is involved in the modulation of NKA activity in the kidneys. The human FXYD8 gene is located on the X chromosome. However, the gene is located on chromosome 9 in the mouse and chromosome 8 in the rat.
Links
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Statistics
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PSSM-Id: 410562
Aligned: 6 rows
Threshold Bit Score: 192.151
Created: 10-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative trimer
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on structures of the Na+/K+ ATPase heterotrimer, composed of alpha, beta, and gamma (FXYD2 or phospholemman-like protein) subunits
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    # # #  ##  ## ##  #  ### ## #                       
P58550         2 EVVLIFVYSLLVPVVLASAAK-EKEIDPFHYNYQTLRIGGLVFDVVLFLVPSCHLLSHRCKCSFNqKPQDPGDKEAQVEN 80  human
EHH30851       2 EVVLIFVCSLLVPVVLASAAKkEKEIDPFHDNYQTLRIGGLVYDMVLFLLSNLHHLSHRCKCSFNqKPQDPGDEEAQVEN 81  Rhesus monkey
XP_016798742   2 EVVLIFVCSLLIPVVLASAAKkEKEIDPFHYNYQTLRIGGLVFDVVLFLVPSRHLLSHRCKCSFNqKPQDPGDEEAQVEN 81  chimpanzee
XP_024096802   2 EVVLIFVCSLLVPVVLASAAKkEKEIDPFHYNYQTLRIGGLVFDVVLFLVLSRHLLSHRCKCSFNqKPQDPGDEEAQVEN 81  Sumatran orangutan
XP_021524315  21 EVVLIFVCSLLIPMVLASAAKkEKEIDPFHCNYQTLRIGGLVFDMVLFLVLSLHILSHKCKCSFNlKAQDPGDEEAQVEN 100 Ma's night monkey
XP_017823914   2 EVVLIFVCSLLIPIVLASAAKkEKEIDPFHCNYQTLSIGGLVFDMVLFLVLSLHILSHRCKCSFHqKPQDPGDEEAQVEN 81  white-tufted-ea...

Feature 1                     
P58550        81 FITANAKEPQKAK 93  human
EHH30851      82 FIIANAKEPQIAK 94  Rhesus monkey
XP_016798742  82 FIIANAKAPQKAK 94  chimpanzee
XP_024096802  82 FIIANAKEPQKTK 94  Sumatran orangutan
XP_021524315 101 FITANAKEPQKAN 113 Ma's night monkey
XP_017823914  82 FITANAKERQKAK 94  white-tufted-ear marmoset

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