Conserved Protein Domain Family
7tmA_FMRFamide_R-like

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cd14978: 7tmA_FMRFamide_R-like 
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.
Statistics
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PSSM-Id: 410630
Aligned: 90 rows
Threshold Bit Score: 115.037
Threshold Setting Gi: 45645182
Created: 23-Sep-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                     #  ##              
Q7Z601       157 VIPVIYYSVLLGLGLPVSLLTAVALARLATrtr----rpSYYYLLALTASDIIIQVVIVFAGFLLQgavlar--qvpqav 230 human
NP_611168     40 VLYGLAVPTLSAFGLCTNFINAVVFMRPKMtp------sAFSYLAALSWMDCISCLLITMTALSRSyfyssp--twityd 111 fruit fly
Q10907         6 SAYLVMVFTVPIAGVILNTYVLRKLIRVARksvvrfettSGLPLAAMSVGDSITLCALLMQAIFHItpkgevptvvlssi 85  Caenorhabditis ...
NP_509379     51 DAFTILQVTCCILGVFGNILNLQTLRSPSLqt------vPFMYIKSLAIFDLIALTMILIHYCLVSttkmaf---vmyyt 121 nematode
Q10904        57 VAHVIVMPIVLSIGMINQCLNVCTLLHIRTs--------IFLYLKASAIADILSIVAFIPFLFRHAklidpswelgmfyh 128 nematode
ELU01645      18 VVWSIWSPVLLLVGLIGNTLSFVTLARQILrh-----rvSTIYFRALCIADSGALLFGLLPIWPLYlagydvt-aqhavi 91  Capitella sp. I...
NP_510476     38 ITYAYIAPFIIIFGIVGDVLTVVTLTHPLLrks----siIYTYLTLLAMTDLLTQFSVIPMIMWLLdiracsk-ssaffy 112 nematode
EFX89018      51 FIYGVVGPTIVTFGLIGNILILFVVGRSRMeg------aIPVYLSALALSDMGALLSSIPLWIRLAqkvacsh-wnafyy 123 common water flea
NP_001027122  60 FVHQYYIPVLCCTGSIGNILSVFVFFRTKLrk-----lsSSFYLAALAVSDTCFLAGLFAQWLNFLnvdiy----nqnyf 130 fruit fly
EEC13395      47 VAYGVVSFVIIALGIVGNLINLVVLTRPNLkg------vTFVYLTWLATSDLLTLVVAVFSMLRLHgiqprty-paafyf 119 black-legged tick
Feature 1        ###### ##  #                                                # #####             
Q7Z601       231 VRTANILEFAANhaSVWIAILLTVDRYTALCHPlhhr----aassPGRTRRAIAAVLSAALLTGIPFywwldmwr----- 301 human
NP_611168    112 YQWQTPLFGISTggANLILACLSLDRFIYLSCFkrnnga-prfcrRKVARCIIVVAIGISIVVNMPYffvfyvsdsgt-- 188 fruit fly
Q10907        86 CKFGIFLIHSTSafSVWCWFFLSVLRYIAVFHPfkyrt---iwrqPRNALKFLAGAVGMFQIYTLIFvtyrqeeksc--- 159 Caenorhabditis ...
NP_509379    122 TYIEAPFINGFLisGLYCSFLLTLERYFLISRPhqkp----tpfpREQARRRIYTMLALSFLIHLPMvlqrrlsvnenge 197 nematode
Q10904       129 AHLELPLINALIsaSALNIVAMTVDRYVSVCHPikffqnnetkpsRRRTMLIIVMIYFIALMIYFPSvfqkklgvvtdal 208 nematode
ELU01645      92 CKLRNFLFITFSdaSIWLICAFTLDRLVAVVFPlkrk----syctRRHALIAITVIWAVATLKNVPMlitwgirethnys 167 Capitella sp. I...
NP_510476    113 AHIGFPLANALMgsSVWIVVFLTLSQYMAVCKPfay------glrSRKICYVLFALAYMFNFCIYAPwavkknvhdisdl 186 nematode
EFX89018     124 GHLELFILNTFMaaSIFNVVALTVERYTSVCLAgqfp----kihtPLRAKMAVATSFLLGLIVSFPLcilkyvvnseeem 199 common water flea
NP_001027122 131 CQFFTFFSYLASfcSVWFVVAFTVERFIAVIYPlkrq----tmctVRRAKIVLFCLTLVGCLHCLPYiviakpvfmpkln 206 fruit fly
EEC13395     120 AHVEMPLVNALMasSVFIVIAVTVDRYWSVCLPtryk----efhnSRRAKLAILSAYVAAALLYVPVafqkspvpvwder 195 black-legged tick
Feature 1                               #  ### ### ##                                            
Q7Z601       302 ---------------dtdsprtlDEVLKWAHCLTVYFIPCGVFLVTNSAiihrlrr------------------------ 342 human
NP_611168    189 ------------chvtefyytnfYKVQNWFTFALLALLPAIFLVIGNGAiiiafrkwtkqsricq--------------- 241 fruit fly
Q10907       160 -------------geydvfhesaFKHVHLLDIFLFYAIPSLLRITLDFLvlihcyspfsvegldrvtidrryaisgpatt 226 Caenorhabditis ...
NP_509379    198 yv------iknnvellcqepnwsLYNYYKLIRECVRFLIVISMTIINIIiarklqitkkrrrrlvrrsspqneip----- 266 nematode
Q10904       209 tnk----tiytivrnedvealqvFKFYLIVRECICRWGPVLLLVILNMCvvrglrkidkrnwfwrqp------------- 271 nematode
ELU01645     168 hh------vskcgvpepdhafyeEYIRPWLVFTTVTFIPFIFITACNIIivhhvqrmglsqat----------------- 224 Capitella sp. I...
NP_510476    187 vpesf-lvsvcpyvvcdakrpdwFVIYETARELISRIFPFFLVAFLNIKilityrntkrdrmer---------------- 249 nematode
EFX89018     200 marnssecrfqylenrnvtahplWTAYVWMGESLVRFLPGLILVILNMLilikyhgvvktrrqmqrg------------- 266 common water flea
NP_001027122 207 ----------tticdlnseykeqLALFNYWDTIVVYAVPFTTIAVLNTCtgctvwkfatvrrtltmhkmkpqtnsmpsns 276 fruit fly
EEC13395     196 anr----tqyvpcdnvsvsrhlvFKIYLLVKEVLVRIGPVLVVAVLNTTiiltfrklmrkrq------------------ 253 black-legged tick
Feature 1                                                                                        
Q7Z601       343 --------------------------------------------------------------------rgrsglqPRVGK 354 human
NP_611168    242 ------------------------------------------------------------annpaansrttakryQHQMK 261 fruit fly
Q10907       227 krfsh----------------------------------tgetdtldnkahvalaisitastntpsvkrihhgnpKKKTA 272 Caenorhabditis ...
NP_509379    267 -------------------------------------------------ngisadsesnvnsftmrredsnlirsFTEKK 297 nematode
Q10904       272 ---------------------------------------------------------sqnsrtetlaqrqlrsprDDRSR 294 nematode
ELU01645     225 --------------------------------------------------------------iarvrsitrqsseISVAS 242 Capitella sp. I...
NP_510476    250 -------------------------------------------------------------lansqkkfmfekseKEEKR 268 nematode
EFX89018     267 ----------------------------------------------------------qpnanangnngrsdrnlEQERK 288 common water flea
NP_001027122 277 snssggassavasyrlsaslkrqkstgthpsgqhnvanrqtddqeqqqqsqqhqinncqhhceitqkparrkvqnSSQLK 356 fruit fly
EEC13395     254 --------------------------------------------------------------qlmnnsnrdtgkfLEEQR 271 black-legged tick
Feature 1                      #  ## ##  #                  ## ###  #  ##                        
Q7Z601       355 STAILLGITTLFTLLWAPRVFVMLYHMyvapv------hrdwrVHLALDVANMVAMLHTAANFGLYCFVSk----tFRAT 424 human
NP_611168    262 LTISIVIVITLYLFGELPAHMTSRKSSlnllfggdankvddsfIEQLEVICITLNALQLSLNIVVYAVINp----sFMPE 337 fruit fly
Q10907       273 MVMRSILISVLNLLLNLPSHIFRAWASydess------leneiVRTLEPIAQMMYFSQFACNAFYLATSIyetngsPRNT 346 Caenorhabditis ...
NP_509379    298 LTVLMISICVIFLLGNVPQIVVMILQNeame--------tnfnFQLYRHCSNTLEVLNHCLNFYVFCIASs----eYTRA 365 nematode
Q10904       295 ISVLLFVTSATFIICNIPASVISFFVRrvsg---------slfWQIFRAIANLLQVTSYLYNFYLYALCSs----eYRHA 361 nematode
ELU01645     243 MSRMCLAVSFTFVVLVSPSIVILVGKPywtkte-----qseakFHLARSFGNLCQYTNNAINFLLYLSSGr----eFRRE 313 Capitella sp. I...
NP_510476    269 LFILLFAIVIVFFVCTIPAAPLTILVAdtkn--------nnvgFQIFRAVVNLLEFTKFAMNFYFYCLINp----dIRSI 336 nematode
EFX89018     289 LLTLLLSIIVLFFITNIPSAVLSIIYDqele--------dshsFQVFRAVANLLEMSNFALNFCMYFLCSk----eFRKM 356 common water flea
NP_001027122 357 VTKMLLIVSTVFVCLNLPSCLLRIEAYwetesa-----rnqnsTIALQYIFHAFFITNFGINFVLYCVSGq----nFRKA 427 fruit fly
EEC13395     272 LVILLAAIVIMFCVCMTPAAVLTVLIGddke--------lnygFQLFRAIANDMEMANFAMNFYVYCLCSs----eIRGT 339 black-legged tick
Feature 1         
Q7Z601       425 V 425 human
NP_611168    338 F 338 fruit fly
Q10907       347 V 347 Caenorhabditis elegans
NP_509379    366 F 366 nematode
Q10904       362 F 362 nematode
ELU01645     314 L 314 Capitella sp. I Grassle & Grassle, 1976
NP_510476    337 C 337 nematode
EFX89018     357 L 357 common water flea
NP_001027122 428 V 428 fruit fly
EEC13395     340 F 340 black-legged tick

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