Conserved Protein Domain Family
7tmA_GPR61_GPR62-like

?
cd15220: 7tmA_GPR61_GPR62-like 
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.
Statistics
?
PSSM-Id: 410633
Aligned: 7 rows
Threshold Bit Score: 215.392
Threshold Setting Gi: 296434526
Created: 7-Dec-2013
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                             #  ##              ###### #
Q9BZJ7        16 LGLILAAVVEVGALLGNGALLVVVLRTPGlrDALYLAHLCVVDLLAAASIMPLGLLAApppglgrvrlgpapCRAARFLS 95  human
EMC83963       8 VGLLCMVLLTLTALVANTLVMVVILKTPLlrKFIFVCHLCVVDLLSAIFLMPLGIISSsscfnrv-iysiaeCKGMIFLN 86  domestic pigeon
CAG06826      33 LALAAMLLMDLLAVVGNVAVMAVIAKAPQlhKFAFVFHLCVVDLLAALVLMPLGMLSGraff------gealCRSYLFLS 106 spotted green p...
Q91178        48 FGLFCMVTLNLIALLANTGVMVAIARAPHlkKFAFVCHLCAVDVLCAILLMPLGIISSspffgtv-vftileCQVYIFLN 126 Japanese medaka
XP_001342078  50 SGLVVMVTLNAIALIANSAVLAIVVKVPHlrKFSLVCHLCIVDLLCAALLMPLGIVCGspffagv-vfsvleCRLYIFLN 128 zebrafish
XP_002194977  37 VGLFFMVLLDLTAIVGNAAVMTVIAKTPAlrKFVFVFHLCLVDFLAALTLMPLEMLSGsavfesp-glgeavCRVYLFLS 115 zebra finch
Q9BZJ8        44 VALFFMLLLDLTAVAGNAAVMAVIAKTPAlrKFVFVFHLCLVDLLAALTLMPLAMLSSsalfdha-lfgevaCRLYLFLS 122 human
Feature 1        #  #                                            # #####                         
Q9BZJ7        96 AALLPACTLGVAALGLARYRLIVhplr---pgsrPPPVLVLTAVWAAAGLLGALSLLgtppapppap------------- 159 human
EMC83963      87 VCFISASILTISIISVERYYYIVhpmryevkmtiRLALAGMVFIWVKSVLITILAVVswplgngatsas----------- 155 domestic pigeon
CAG06826     107 VCLVSAAILSISVINVERYYYIVhpmryevrmtvGLVASVLVGVWVKALAMSALPLLawflqsgrtpllesggvggegaa 186 spotted green p...
Q91178       127 VFLIWLSILTITAISVERYFYIVhpmryevkmtiNLVIGVMLLIWFKSLLLALVTLFgwppyghqssiaa---------- 196 Japanese medaka
XP_001342078 129 AFLVSASIFTVTVISIERYFYIVhpmryeakmtpWLSAAVMGLVWVASTLLGLATVFgwpsygsrssiaa---------- 198 zebrafish
XP_002194977 116 VCLTSMCILSISTINVERYYYVVhplryevrmtaGLVAGVLAGVWLKAVATSLVPVLgwlspdrpptsgt---------- 185 zebra finch
Q9BZJ8       123 VCFVSLAILSVSAINVERYYYVVhpmryevrmtlGLVASVLVGVWVKALAMASVPVLgrvsweegapsvp---------- 192 human
Feature 1                              #  ### ### ##                                             
Q9BZJ7       160 -------------arcsvlaggLGPFRPLWALLAFALPALLLLGAYGGIFVVarraalrpprpargsrlh---------- 216 human
EMC83963     156 -----------rctvywspgahKKAFVIIFSIVCFVLPTVLIFAVYCSVYRVarmaslqhvpmpaptqaaaprhrse--- 221 domestic pigeon
CAG06826     187 alypppqghrrcslhwtgggsnRLAFMVLFTLVYFLCPLLVILVVYCNMFKVarvaamhhgplptwmdtprrqrses--- 263 spotted green p...
Q91178       197 ----------shcslhashsrlRGVFAVLFCVICFLAPVVVIFSVYSAVYKVarsaalqqvpavptwadaspakdrs--- 263 Japanese medaka
XP_001342078 199 ----------thcslhwshsghRRVFAILFCTVCFCVPAAIIIAVYGNVYKVahtaarergpipswtiatahpkrrsdsv 268 zebrafish
XP_002194977 186 ----------rgcslqwsrgpsCKVFVVFFAAFYFVLPLLIILVVYCGMFKVarvaamhhgppptwmetprrrsa----- 250 zebra finch
Q9BZJ8       193 ----------pgcslqwshsayCQLFVVVFAVLYFLLPLLLILVVYCSMFRVarvaamqhgplptwmetprqrse----- 257 human
Feature 1                                                     #  ## ##  #         ## ###  #  ##  
Q9BZJ7       217 --------sdsldsrlsilpplrprLPGGKAALAPALAVGQFAACWLPYGCACLAPaa------rAAEAEAAVTWVAYSA 282 human
EMC83963     222 -siashvtiittrnlplprltserfLGSNKAIVTLVLIVGQFLCCWLPFFAFHLHSsvaa-gtvgGGHGEMVVTWIAYSS 299 domestic pigeon
CAG06826     264 lssrstmvtssgtgsgtgrvtpqrpFGGGKAAAVLVAVGGQFLCCWLPYFTFHLYSalaasppaaLASMEEVVTWIGYFC 343 spotted green p...
Q91178       264 -dsinsqttiittrtlpqrlsperaFSGGKAALTLAFIVGQFLVCWLPFFIFHLQMsltg-smksPGDLEEAVNWLAYSS 341 Japanese medaka
XP_001342078 269 nsqttiittstsvrrnqvprrkrrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLslgi-shstSEEAEGPVTWLAYST 347 zebrafish
XP_002194977 251 ---slssrstmvttsgaprttpqriFGGGKAAAVLLAVGGQFLFCWLPYFSFQLYTalst-rplaGPAAETVVTWLGFCC 326 zebra finch
Q9BZJ8       258 ---slssrstmvtssgapqttphrtFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYValsa-qpisTGQVESVVTWIGYFC 333 human
Feature 1                           
Q9BZJ7       283 FAAHPFLYGLLQrpVRLAL 301 human
EMC83963     300 FAINPFFYGLLNrqIREEL 318 domestic pigeon
CAG06826     344 FTTNPFFYGCLNrqIREEL 362 spotted green pufferfish
Q91178       342 FAVNPSFYGLLNrqIRDEL 360 Japanese medaka
XP_001342078 348 FAVNPFFYGLLNrqIREEL 366 zebrafish
XP_002194977 327 FTSNPFFYGCLNrqIRGEL 345 zebra finch
Q9BZJ8       334 FTSNPFFYGCLNrqIRGEL 352 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap