3SN5,3DAX


Conserved Protein Domain Family
CYP7A1

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cd20631: CYP7A1 
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cytochrome P450 family 7, subfamily A, polypeptide 1
Cytochrome P450 7A1 (CYP7A1) is also called cholesterol 7-alpha-monooxygenase (EC 1.14.14.23) or cholesterol 7-alpha-hydroxylase. It catalyzes the hydroxylation at position 7 of cholesterol, a rate-limiting step in the classic (or neutral) pathway of cholesterol catabolism and bile acid biosynthesis. It is important for cholesterol homeostasis. CYP7A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410724
Aligned: 12 rows
Threshold Bit Score: 746.895
Threshold Setting Gi: 1126172108
Created: 8-Sep-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #                            #    
3SN5_A        38 FLRANQRKHGHVFTCKlmgKYVHFITnPLSYHKVLCHGKyfdwKKFHFALSAKAFGHRSIdpmd-gntTENINDTFIKTL 116 human
3DAX_A        38 FLRANQRKHGHVFTCKlmgKYVHFITnPLSYHKVLCHGKyfdwKKFHFATSAKAFGHRSIdpmd-gntTENINDTFIKTL 116 human
XP_006003615  56 FLRARQKKYGHIFTCKiagRFVHFLTdPFSYHSVIRQGRhldwKKFHFSASVKAFGHDSMdpnd-gytTENLHQTFIKTL 134 coelacanth
AAH54571      56 FLRSRQKKHGHIFTCKiagQYVHFLCdPFSYHAVIRQGRhldwKKFHFDASAKAFGHESMdpsq-gytTENLHQTFLKTL 134 zebrafish
NP_001001753  56 FLREKQKKHGHIFTCQvagKYIHFLTdPFSYHSLIRQGKhldwKKFHFATSAKAFGHGSIdpae-gntTENFHHTFIRTL 134 chicken
OCT74752      55 FLRVRQNKFGNIFTCKiagQFVHFVTdPFSFSSVMRHGRhfdwQKFHFATSAKAFGHSMLdssd-selTQIVHDSFLKTL 133 African clawed ...
P22680        55 FLRANQRKHGHVFTCKlmgKYVHFITnPLSYHKVLCHGKyfdwKKFHFATSAKAFGHRSIdpmd-gntTENINDTFIKTL 133 human
XP_006003627  36 FLNSRKKKYGSTFTCKiagKYLTFITdPFSYSSVIRHGKsldfQKFALETSRNAFGHVDFsdskygitYDEIHHIFLKTL 115 coelacanth
XP_006000107  63 FLQRRKAKYGEIFTCKitnNYYHFIAdPLSYGNVSRHGKyldwKKFQFATSTKVFGHGNMdpkf-gntSENLHDTFVKML 141 coelacanth
KPP62426     185 FLRSMQRKYGDIFTCKiagSYFTFVLdPFSYGAVSRQGRnldfQKFAIGFSHKVFGHADFndpvysynIKDIHSIFRQTL 264 Asian bonytongue
XP_007894899  56 FMQARQNKYGEIFTCKiagKFITFITdPFSYTSVIRHGKsldfQKVALTISKNVFGHVDFtky--digNDEIHNIFNRTL 133 elephant shark
XP_019618131  54 FIRSRQEKYGDVFTVKlagKFTTFVLdPHSYSDVMRQHKildfKTVGMDIVERGFGTTHFertgrahiLHTADAYFPVHL 133 Belcher's lancelet
Feature 1                                                                                        
3SN5_A       117 QGhalNSLTESMMENLQRIMRPPVssnsktaa-wvtegmysFCYRVMFEAGYLTIFGRdltrr--------dtqkaHILN 187 human
3DAX_A       117 QGhalNSLTESMMENLQRIMRPPVssnsktaa-wvtegmysFCYRVMFEAGYLTIFGRdltrr--------dtqkaHILN 187 human
XP_006003615 135 QGdalKSLIETMMENLQYVMLHSNtlklnsre-watdglyaFCYKVMFESGYLTLFGKelnfsedkvtarleaqraLILN 213 coelacanth
AAH54571     135 QGdalSSLIETMMENLQGTMLQSGmlkattse-wqsdgiyaFCYKVMFEAGYLTLFGKeldgdqsi--arqqaqkaLVLN 211 zebrafish
NP_001001753 135 QGnalDALIKAMMENLQYVMLQSRaskfqpnt-wvteglytFCCQVMFESGFLTLFGKefnsnhdknlskreteraRILN 213 chicken
OCT74752     134 QGealDPLISSMMENLQHTMLQNSsyevnska-wvteglyaFCYRVMFEAGYLTLFGKefnsledknlarqeaqraLILN 212 African clawed ...
P22680       134 QGhalNSLTESMMENLQRIMRPPVssnsktaa-wvtegmysFCYRVMFEAGYLTIFGRdltrr--------dtqkaHILN 204 human
XP_006003627 116 QGsalGPLTQSMMANLHSVMLRDKtssasiw---tteglqaFVTRIIFEAGFLTLFGKnmkenttd---rlqsqqvAVQA 189 coelacanth
XP_006000107 142 QGeplGHMTENMMENLQYVMLGSRnaskqakfdwtseglysFCYEKMFEAGYMTLFGKdlkdheennyskleahrfLILN 221 coelacanth
KPP62426     265 QGpvlQQLISTMMENLQAVMRRDEghgwtt------eglqvFVERIMFEAGYLTLFGKeeeaeamat-ggatprwlFMRQ 337 Asian bonytongue
XP_007894899 134 QGlslGSLTSSMMENLQFVMSQGKsssdsssw--tienlyeFSCKIMFEAGHLTLFGKndkamkggdvekikqqhdAIQF 211 elephant shark
XP_019618131 134 QGsalDPLTNCMMGHLQTAMLADMgpetawk----kdglwsFVRRIISEASFLTIFGRhktqpv-------eqeraRFMV 202 Belcher's lancelet
Feature 1                                                                                        
3SN5_A       188 NLDNFKQFDKVFPALVAGlpihmfrTAHNAREKLAESLRHENLQKresiSELISLRMFLNdtlstfdDLEKAKTHLVVLW 267 human
3DAX_A       188 NLDNFKQFDKVFPALVAGlpihmfrTAHNAREKLAESLRHENLQKresiSELISLRMFLNdtlstfdDLEKAKTHLVVLW 267 human
XP_006003615 214 ALENFKEFDKIFPALVAGlpihvfkNAHSARENLAKNLLHENLRRrnniSDLISLRMVLNdtlstmnDMAKARTHVALLW 293 coelacanth
AAH54571     212 ALDNFKEFDKIFPALIAGlpihvfkSAYSAREKLAKTMLHENLSRranvSDLISLRMLLNdtlstfnELSKARTHVAILW 291 zebrafish
NP_001001753 214 ALENFKEFDKIFPALVAGlpihlfkSAHSAREKLGEALLHKNLLKrdnlSELVMLRMFLNdtlstfdDMEKAKTHVAVLW 293 chicken
OCT74752     213 AIENFKEFDKIFPALVAGlpihvfkSAYSARENLAKDLLHENLRKryniSELVSLRMLMNdtmtslnDTEKAKTHLALLW 292 African clawed ...
P22680       205 NLDNFKQFDKVFPALVAGlpihmfrTAHNAREKLAESLRHENLQKresiSELISLRMFLNdtlstfdDLEKAKTHLVVLW 284 human
XP_006003627 190 ALEDFKKFDMAFPALVAGvpisflqGAKKAREALAERFLPMKMKQnecvSSLIEQRIKLFdssphlsEVTKARTHVIMLW 269 coelacanth
XP_006000107 222 ALKDFQRLDKVFPALVAGfsihlfrNAYKSREALAEGLCHSVLQKwqklSPLITLRILLNdtlsnfdEMEKGRTHVAILW 301 coelacanth
KPP62426     338 AMEDFHAFDKAFPEMAAGlpihlcgRAFRAREALAEKLHHRHLKRnkclSALIERRMHAFdqmeqldEKEKARTHVSMLW 417 Asian bonytongue
XP_007894899 212 ALEEFKAFDTVFPALVAGipmgffkTAKKARKALEGRLLNKTLREqdckSALIKERMELFdssssldEHNKAKTHVIMLW 291 elephant shark
XP_019618131 203 AMETFWEYDRKFPQVVAGipwcmlgKAKGQLDFLLTFMHKDQLSQrh-vLQLIEQRDEVFcgg-glsGRELAGAHFSTMW 280 Belcher's lancelet
Feature 1        ##  ##  #                                                                     # 
3SN5_A       268 ASQANTIPATFWSLFQMIRNPEAMKAATEEVkrtlenagqkv---slegnpiclsqAELNDLPVLDSIIKESLRLSSaSL 344 human
3DAX_A       268 ASQANTIPATFWSLFQMIRNPEAMKAATEEVkrtlenagqkv---slegnpiclsqAELNDLPVLDSIIKESLRLSSaSL 344 human
XP_006003615 294 ASQANTLPATFWSLFYLIRSPEAMKAATEEVqktleksgqka---sldgshislmrEELNNMPVLDSIIKEAMRLSSaSL 370 coelacanth
AAH54571     292 ASQANTLPATFWTLFHMIRCPAAMKAASEEVrqtfessnqkv---dptnsrlvltrEQLDNMPVLDSIIKEAMRLSSaSL 368 zebrafish
NP_001001753 294 ASQANTIPATFWSLFYLLKNPEAMRAATKEVqsvlesageki---sldgnyislnrKQLDNMPVLDSIIKEAMRLSSaSM 370 chicken
OCT74752     293 ASQANTLPATFWSVFYLLKCPHAMKASKEEVhrvlekasqkv---nndgkyiflnrHELDDMPVLDSIIKEAMRLSSaSL 369 African clawed ...
P22680       285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVkrtlenagqkv---slegnpiclsqAELNDLPVLDSIIKESLRLSSaSL 361 human
XP_006003627 270 AAQANTLPATFWSTYYLLRSPEALLAVRKEIdnmlyltdqky---rdatqsisftkEQLENMPTMGSVISEALRLSSaSI 346 coelacanth
XP_006000107 302 ASHANTLPATFWALFYILRCPKAKQAIQKEIkmmlqktkqk-----vgqqqsvikqDDFGLMPILGSAVKEALRLSSaSL 376 coelacanth
KPP62426     418 ASQANTLPATFWSLYYILRCPVALDAAQAEVrrvlgesghtp---gnlekpvvlskDQLAGMSVLGSIIEEALRLSSaSI 494 Asian bonytongue
XP_007894899 292 ASQANTLPASFWSIYYLMRNPEALNAVKNEVenilkvtnqkp---gdinspiiftrEQLDSMTNMGSLINEVLRLSSaSM 368 elephant shark
XP_019618131 281 ASLSNTLPTAFWTLFHLLQDPVAMAAVRKEVetllketgqtvsgfrdggekidftrQQLADMACLGSVVNEALRVSSvSI 360 Belcher's lancelet
Feature 1        #                                                                          ##   
3SN5_A       345 NIRTAKEDFTLHLe-DGSYNIRKDDIIALYPQLMHlDPEIYPDPLTFKYDRYldENGKTKTTFycnglklkYYYMPFGSG 423 human
3DAX_A       345 NIRTAKEDFTLHLe-DGSYNIRKDDIIALYPQLMHlDPEIYPDPLTFKYDRYldENGKTKTTFycnglklkYYYMPFGSG 423 human
XP_006003615 371 NVRVAKENFTLLLdnDESYSIRKDDVIALYPQLLHfDPKIYEDPMTFKYGRYldENGQEKTTFyrdgrklkYYYMPFGSG 450 coelacanth
AAH54571     369 NVRMAKSDFLLQLdnKESYHIRKDDVIAMYPPMIHfDPEIYDDPLEFKYDRYidEKGQEKTAFyrngrklrYYYMPFGSG 448 zebrafish
NP_001001753 371 TFRVAKEDFTLHLe-NSFYNIRKDDIVALYPQLLHfDPEIYADPLTLKYDRYlnENKEEKTDFyrngrklkYYYMPFGAG 449 chicken
OCT74752     370 NIRVAKENFVLHMddNQAYYIRKDDIVALYPQVVHlNPDIYENPNTFKYDRYlgEDGKEKTNFflngrklkYYYMPFGSG 449 African clawed ...
P22680       362 NIRTAKEDFTLHLe-DGSYNIRKDDIIALYPQLMHlDPEIYPDPLTFKYDRYldENGKTKTTFycnglklkYYYMPFGSG 440 human
XP_006003627 347 MIRCATEDFTLTLdsGEKLAIRKGDRIALVPQLQHlDPEIYENPLEFQYDRFldKTGKEKTTFykngkklkHYLMPFGSG 426 coelacanth
XP_006000107 377 NIRAVKEDFRFVMdsGRSYAIRKDDYIVLYPPLLHfDPEIYENPMDYQYDRFldSAGQEKKVFykngrmlkCYFLPFGSG 456 coelacanth
KPP62426     495 MIRVASENFTLTLdtGKTAAIRKGDHIAMFPQMMHmDPEIYEDPTEFQCSRFldENGQKKTDFykngrklrQFLLPFGSG 574 Asian bonytongue
XP_007894899 369 MIRVATEDLLLTLdsGRKVAIRKGDQIALYPQLLHlDPEIYEDPHEFKYNRFldENGKDKTTFykngrklkYYLMPFGSG 448 elephant shark
XP_019618131 361 VLRQALEETTIALnsGSTFKIRKGDRVALFPQIVHmDPEVYEDPETFKYDRYleNGKEKTTFYkngk-klrHYLVPFGIG 439 Belcher's lancelet
Feature 1         # ###  ##  #                                  #         
3SN5_A       424 ATICPGRLFAIHEIKQFLILMLSYFElelieGQAKCPPLDQsraGLGILPPLNDIEF 480 human
3DAX_A       424 ATICPGRLFAIHEIKQFLILMLSYFElelieGQAKCPPLDQsraGLGILPPLNDIEF 480 human
XP_006003615 451 VTKCPGRFFAVHEIKEFLTLLLTYFElelvdKNAKCPPLDQsraGLGILQPTHDVDF 507 coelacanth
AAH54571     449 VTKCPGRFFAVHEIKQFLSLLLSYFEmelldSDVKEPPLDQsraGLGVLQPTYDVDF 505 zebrafish
NP_001001753 450 IAKCPGRLFAVHEIKQFLVLIFSYFEidlvdSNVQCPSLDQsraGLGILQPSNDIDF 506 chicken
OCT74752     450 KTKCPGRQFAVHEIKQMLTLIICYFDmelvdKNVRSPPLDQsraGLGVLQPTHDVDF 506 African clawed frog
P22680       441 ATICPGRLFAIHEIKQFLILMLSYFElelieGQAKCPPLDQsraGLGILPPLNDIEF 497 human
XP_006003627 427 TSMCPGRFFAINEIKQFLSLLLCYYDielldRSAPPLPLDNsraGLGILQPKHDVGI 483 coelacanth
XP_006000107 457 MAKCPGRHLAMNEIKQFLVLMLCYYDiellePNGAIPPLDQsraGLGVLPPTFDIKF 513 coelacanth
KPP62426     575 VSECPGRFFAINEIKQFLTLALCHYDmelhdLAAAPLETDCtraGLGILPPKHDVSL 631 Asian bonytongue
XP_007894899 449 TSICPGRHFAINEIKQFLSLMLCYYDmelldFTALSPTLNNtraGLGILQPSNDVLF 505 elephant shark
XP_019618131 440 TSRCPGRFFAVNEIKQFVSLIVCYFDme--lVDRETPPLDQsrtGLGILPPSTDPVF 494 Belcher's lancelet

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