Conserved Protein Domain Family
CYP2J

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cd20662: CYP2J 
cytochrome P450 family 2, subfamily J
Members of CYP2J are expressed in multiple tissues in mice and humans. They function as catalysts of arachidonic acid metabolism and are active in the metabolism of fatty acids to generate bioactive compounds. Human CYP2J2, also called arachidonic acid epoxygenase or albendazole monooxygenase (hydroxylating), is a membrane-bound cytochrome P450 primarily expressed in the heart and plays a significant role in cardiovascular diseases. The CYP2J subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410755
Aligned: 8 rows
Threshold Bit Score: 783.216
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #              ##      #   #                
P51589        75 YGNLFSLELGdiSAVLITgLPLIKEALIHMDQNFGNRPVTpmrehifkKNGLIMSSGQAWKEQRRFTLTALRNFglgkks 154 human
AAH45948      66 YGKVFSLRVGseKMIIVSgYKMVKEALVTQNDSFVLRPPVplfhkvykGIGLTMSNGYIWRSHRRFAASHLRTFgegkkn 145 zebrafish
CAG32696      68 HGDIFSTQVGsmSFVIVNgLPLIKEALVTQGENFMDRPEFpinteflnKFGLVFSNGHLWKQQRRFTLTTLRNFglgkrs 147 chicken
NP_075414     75 YGNIFSLNLGdiTSVVITgLPLIKETFTHIEQNILNRPLSvmqeritnKNGLIFSSGQTWKEQRRFALMTLRNFglgkks 154 Rattus norvegicus
O54750        75 YGNIFSLNLGdiTSVVITgLPLIKEALTQMEQNIMNRPLSvmqerisnKNGLIFSSGQIWKEQRRFALMTLRNFglgkks 154 house mouse
P51590        75 YGNVLSLDFAniPSVVVTgMPLIKEIFTQMEHNFLNRPVTllrkhlfnKNGLIFSSGQTWKEQRRFALMTLRNFglgkks 154 Norway rat
O54749        75 YGNVFSLELGqsPVVVVSgLPLIKEMFTHLDQNFVNRFMTpvreritgKNGLVVSNGQTWKEQRRLALMALRNFglgkks 154 house mouse
NP_001316410  68 LGDIFSMQAGsqSFVIVNgLPLIKEALVTQGENFMDRPEIpldtdifsKLGLISSSGHLWKQQRRFTLTTLRNFglgkrs 147 Gallus gallus
Feature 1                                                                                        
P51589       155 lEERIQEEAQHLTEAIKEEngqpfdPHFKINNAVSNIICSITFGERFEYqdSWFQQLLKLLDEVTYLEAsktcqlynvfp 234 human
AAH45948     146 lELGIQQECVCLCDAFKAEkep-fnPIFILHGAVSNTVACLTFGQRFDYndEWYQEILRLDNQCVQLAGsprvqlynafp 224 zebrafish
CAG32696     148 lEERIQEECRFLTDAFRDEqgnpfnPHLKVNNAVSNIICSVTFGNRFEYhdEDFQNLLRLMDETVTLQGepmsqlyaffp 227 chicken
NP_075414    155 lEQRMQEEAHYLVEAIREEkgkpfnPHFSINNAVSNIICSVTFGERFEYhdSRFQEMLRLLDEVMYLETtmisqlynifp 234 Rattus norvegicus
O54750       155 lEERMQEEASHLVEAIREEegkpfnPHFSINNAVSNIICSVTFGERFDYhdSRFQEMLRLLDEVMYLETtmisqlynifp 234 house mouse
P51590       155 lEQRIQEEAYHLVEAIKDEgglpfdPHFNINKAVSNIICSVTFGERFEYhdSQFQEMLRLLDEAMCLESsmmcqlynifp 234 Norway rat
O54749       155 lEERIQEETHHLVEAIREEggqpfnPHLKLINAVSNIICSVTFGERFDYedCQFQELLQLLDETMHLMGssagqlyngfp 234 house mouse
NP_001316410 148 lEERIQEECRFLTEAFRDEqgnpfnPHLKINNAVSNIICSVTFGNRFEYhdENFQTLLRLMDETVTLHEkimsqlynafp 227 Gallus gallus
Feature 1                                                                                 #  ##  
P51589       235 wimkflpgpHQTLFSNWKKLKLFVSHMIDKHrkdwnpaetRDFIDAYLKEMskhtgnptssfHEENLICSTLDLFFAGTE 314 human
AAH45948     225 klldylpgpHQKVFSNYKKITQSLKDEIIKHredwdpanpRDFIDNYLTEMekkksdpqagfNIESLIISCLDIVEAGTE 304 zebrafish
CAG32696     228 siikyfpgsHQTVLKNEKLMKRFVCKKISKHkedlspsesRDFIDSYLQEMakps---gsdfCEDNMVSCTLDLFFAGTE 304 chicken
NP_075414    235 wimkyipgsHQTVFRNWEKLKLFVSSMIDDHrkdwnpeepRDFIDAFLKEMskype-kttsfNEENLICSTLDLFFAGTE 313 Rattus norvegicus
O54750       235 wimkyipgsHQKVFRNWEKLKLFVSCMIDDHrkdwnpdepRDFIDAFLKEMtkype-kttsfNEENLICSTLDLFFAGTE 313 house mouse
P51590       235 rilqylpgsHQTLFSNWRKLKLFISDIIKNHrrdwdpdepRDFIDAFLKEMakypdktttsfNEENLICSTLDLFFAGTE 314 Norway rat
O54749       235 cimkylpgpHQKIFRNWGKLKLFVSHIVKKHekdwnpdepRDFIDAFLIEMqkdpd-rttsfNEENLISTTLDLFLGGTE 313 house mouse
NP_001316410 228 sivkylpgsHQTIFKNWRLMKDFVNEKISKHkedlnpsesRDFIDSYLQEMakps---gsefHEENLVACALDLLFAGTE 304 Gallus gallus
Feature 1        ##  #                                                  #     #   # #            
P51589       315 TTSTTLRWALLYMALYPEIQEKVQAEIDRvigqgqqpstaaresMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYH 394 human
AAH45948     305 TGATTLRWGLLFMIKFPEIQKKVQAEIDRvigqsrqpclddrvnMPYTEAVLHEIQRFGDVVPLGFPKQAAVDTKIGNYF 384 zebrafish
CAG32696     305 TTSTTIRWALLYMAIYPEIQARVQAEIDAvigqarlpaledrsnMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFR 384 chicken
NP_075414    314 TTSTTLRWALLYMALYAEVQEKVQAEIDRvigqkraasladresMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGFH 393 Rattus norvegicus
O54750       314 TTSTTLRWALLYMALYPEVQEKVQAEIDRvigqkraarladresMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFH 393 house mouse
P51590       315 TTSTTLRWALLCMALYPEVQEKMQAEIDRvigqgrqpnladrdsMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFN 394 Norway rat
O54749       314 TTSSTLRWALLYMSSYPEIQENVQAEIDRvighkrqvslsdresMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNGFH 393 house mouse
NP_001316410 305 TTSTTIRWALLFMAVYPEIQAHVQAEIDAvigqarqpaledrnnMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFR 384 Gallus gallus
Feature 1                  #                                   ###   # ###  ##                   
P51589       395 LPKGTMILTNLTALHrDPTEWaTPDTFNPDHFlen-gqFKKREafMPFSIGKRACLGEQLARTELFIFFTSLMQKFTfrp 473 human
AAH45948     385 IPKGTSITTNLSSVLhDPNEWeTPDTFNPGHFldkngqFRKRDafLPFSAGKRACVGELLARNVLFLFFTSLLQQFTlsk 464 zebrafish
CAG32696     385 VPKGTILIPNLSSVMyDKKEWeTPHSFNPGHFlkd-gqFWKREafMPFSIGKRACLGELLARAELFLFFTALLQKFTfqa 463 chicken
NP_075414    394 LPKGTMVLTNLTALHrDPKEWaTPDVFNPEHFlen-gqFKKREsfLPFSMGKRACLGEQLARSELFIFFTSLMQKFTfkp 472 Rattus norvegicus
O54750       394 LPKGTMVLTNLTALHrDPKEWaTPDVFNPEHFlen-gqFKKREsfLPFSMGKRACLGEQLARSELFIFFTSLMQKFTfnp 472 house mouse
P51590       395 LPKGTMILTNLTALHrDPKEWaTPDTFNPEHFlen-gqFKKREsfLPFSMGKRACLGEQLARSELFIFITSLIQKFTfkp 473 Norway rat
O54749       394 LPKGTMILTNLTALHrDPKEWaTPEVFNPEHFlen-gqFKKREsfLPFSMGKRACLGEQLAKSELFIFFSALMQKFTfkp 472 house mouse
NP_001316410 385 VPKGTILIPNLSSVMyDKKEWeTPHSFNPGHFlkd-gqFWKREafMPFSIGKRACLGELLARAELFLFFTSLLQKFTfqa 463 Gallus gallus
Feature 1                               
P51589       474 pnnEKLSLKFRMgITISPVSHRL 496 human
AAH45948     465 cpgEEPSLEGEIwFTYAPAPFRI 487 zebrafish
CAG32696     464 ppdTILDLKFTVgITLAPQPYKI 486 chicken
NP_075414    473 ptnEKLSLKFRNgLTLSPVTHRI 495 Rattus norvegicus
O54750       473 pinEKLSPKFRNgLTLSPVSHRI 495 house mouse
P51590       474 pvnEKLSLQFRMsVTISPVSHRL 496 Norway rat
O54749       473 pinEKLSLKFRMgLILSPASYRI 495 house mouse
NP_001316410 464 ppdTILDFKFTMgITLAPRPYKI 486 Gallus gallus

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