Conserved Protein Domain Family
CYP2AB1-like

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cd20667: CYP2AB1-like 
cytochrome P450, family 2, subfamily AB, polypeptide 1 and similar cytochrome P450s.
The function of CYP2AB1 is unknown. CYP2AB1 belongs to family 2 of the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410760
Aligned: 4 rows
Threshold Bit Score: 802.132
Threshold Setting Gi: 115528339
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #              ##      #   #                
XP_017172441  23 HGSVFTVWlgstPIVVLSgFRAVKEALVSNSEQFSGRPLTPFfrdlfgEKGVICSNGLTWRQQRRFCLTTLRELglgkqa 102 Mus musculus
AAI24959       5 YGDIYTLWlghtPLVVLSgCKSVRNGLISHSEELSGRPVDSFlqaltnERGIVSTNGHTWKQQRRFGMMTLRNLglgkrg 84  African clawed ...
XP_027746360  62 YGNIYTLWmgqtPMVVLNgYKAVKDGLVTHSEEVSGRPLTPFyrdmmgEKGIFLTSGRTWKQQRRFVMTIVRSLalgknn 141 Empidonax traillii
EDL77990      55 HGNVFTVWlgstPIVVLNgFRAVKEALVSNSEQFSGRPLTPFfrdlfgEKGVICSNGLTWRQQRRFCLTTLRELglgkqa 134 Norway rat
Feature 1                                                                                        
XP_017172441 103 lEVQLQHEAAELAKVFLQEegrafdPQIPIIRSTTRVIGTLVFGHHFLSeePIFLELIQAINLGLAFASTIWrrlydmfp 182 Mus musculus
AAI24959      85 lESRIQEEAQCLVKSLAAKngepvnPSDLIVHAVANVISAVVFGHRFSIedPTFQEMVRCNNCLVTNMGTAWgrmydafp 164 African clawed ...
XP_027746360 142 lEHQIQTEACHLVDIFANTkgkpfdPHTSIVHAIANIICAVVFGHRFSSedESFSKLIKAIYLVIYFQATIWgrlydafp 221 Empidonax traillii
EDL77990     135 lELQLQHEAAELAEVFHQEqgrafdPQVPIIRSTTRVIGALVFGHHFLSeePIFLELIRAINLGLAFASTTWrrlydmfp 214 Norway rat
Feature 1                                                                                 #  ##  
XP_017172441 183 walrhlsGPHQKIFQYHEAVRGFIRHEIIRHklrt-aeaPKDFINCYLSQITKaiddpvstFSEENLIQVVIDLFLGGTD 261 Mus musculus
AAI24959     165 wlmqyvpGPHHSCFAAMDYLASFIKKEVKLHelndsneePQDIIDYYLAQIAKtkqepdstFDEANMINVVTDLFVAGTE 244 African clawed ...
XP_027746360 222 wlmhhlpGPHQKVFAYNDFMHSLVMKEVQAHekek-ksdPQDLIDFYLAQITKtkddptstFNKDNMIQTVVDLLLGGTE 300 Empidonax traillii
EDL77990     215 walrylsGPHQKIFQYHEAVRGFIHHEIIRHklrt-peaPKDFISCYLSQITKamddpvstFSEENLIQVVIDLFLGGTD 293 Norway rat
Feature 1        ##  #                                                  #     #   # #            
XP_017172441 262 TTATTLHWALIYLVHHRAIQERVQQELDEmlgaaqticyedrerLPYTRAVLHEVQRLSSVVAVGAVRQCVTSTWMHGYY 341 Mus musculus
AAI24959     245 TTAITLQWALLYMVAFPEIQKKVQEELDSvldgsqlayyedkkiLPFTNAVIHEVQRYGNIASVGIPRSCIRKATVNGYK 324 African clawed ...
XP_027746360 301 TTSTTLLWALLYMVQHPEIQEKVQREIDDvveashpisyedrkkLPYTNAVIHEALRFSNVTSVGVLRQCVSSTTLLGFH 380 Empidonax traillii
EDL77990     294 TTATTLHWAIIYLVHHRAIQERVQQELDEvlgtaqavcyedrerLPYTRAVLHEVQRLSSVVAVGAVRQCVTPTWMHGYY 373 Norway rat
Feature 1                  #                                   ###   # ###  ##                   
XP_017172441 342 VPKGTIILPNLASVLyDPECWeSPHQFNPGHFldkdgnFVANEafLPFSAGHRVCPGEQLARMELFLMFATLLRTFQfql 421 Mus musculus
AAI24959     325 LEKNTMVLPNLDSVLhDQHQWeTPYKFNPNHFldkngnFRMNEafLPFSAGHRVCLGEQLARFELFIFFTTLLRRFNiel 404 African clawed ...
XP_027746360 381 IKKGTLILPNLHSVVyDSEHWaTPWKFNPDHFldldgnFVNKEafLPFSAGHRVCLGENMARIELFIFFTNLLRAFSfql 460 Empidonax traillii
EDL77990     374 VSKGTIILPNLASVLcDPECWeTPHQFNPGHFldkdgdFVTNEafLPFSAGHRVCPGEQLARMELFLMFATLLRTFRfql 453 Norway rat
Feature 1                                
XP_017172441 422 pegsQDLGLEYVFgGTLQPQPQKI 445 Mus musculus
AAI24959     405 pkgvTEVNTKYVFkMTLQPHPYEI 428 African clawed frog
XP_027746360 461 pegvKEISSEYVLgAILQPLPYKL 484 Empidonax traillii
EDL77990     454 pegsQGLRLEYVFgGTLQPQPQKI 477 Norway rat

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