2P85,2PG5,3EBS,1Z10,2PG6,2PG7


Conserved Protein Domain Family
CYP2A

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cd20668: CYP2A 
Click on image for an interactive view with Cn3D
cytochrome P450 family 2, subfamily A
Cytochrome P450 family 2, subfamily A (CYP2A) includes CYP2A1, 2A2, and 2A3 in rats; CYP2A4, 2A5, 2A12, 2A20p, 2A21p, 2A22, and 2A23p in mice; CYP2A6, 2A7, 2A13, 2A18P in humans; CYP2A8, 2A9, 2A14, 2A15, 2A16, and 2A17 in hamsters; CYP2A10 and 2A11 in rabbits; and CYP2A19 in pigs. CYP2A enzymes metabolize numerous xenobiotic compounds, including coumarin, aflatoxin B1, nicotine, cotinine, 1,3-butadiene, and acetaminophen, among others, as well as endogenous compounds, including testosterone, progesterone, and other steroid hormones. Human CYP2A6 is responsible for the systemic clearance of nicotine, while CYP2A13 activates the nicotine-derived procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into DNA-altering compounds that cause lung cancer. The CYP2A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410761
Aligned: 21 rows
Threshold Bit Score: 832.521
Threshold Setting Gi: 1331351401
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #              ##          #                
2P85_A     43 YGPVFTIHlgprRVVVLCgHDAVKEALVDQAEEFSGRGEQATFDWLFkGYGVAFSNGERAKQLRRFSIATLRGFgvgkrg 122 human
AUR34092   65 YGPVFTIHlgprRVVVLCgYDAVKEALVDQAEEFGGRGKQAMFDWLFrGYGVSFSNGERAKQLRRFSIMTLRNFgmgkrs 144 Eremias argus
P20852     65 YGPVFTIYlgprRIVVLCgQEAVKEALVDQAEEFSGRGEQATFDWLFkGYGVVFSSGERAKQLRRFSIATLRDFgvgkrg 144 house mouse
P15392     65 YGPVFTIYlgsrRIVVLCgQETVKEALVDQAEEFSGRGEQATFDWLFkGYGIAFSSGERAKQLRRFSITTLRDFgvgkrg 144 house mouse
Q05556     65 YGPVFTIHlgprRIVVLCgQEAVKEALVDQAEDFSGRGEQATFDWLFkGYGVAFSTWERARPLRRFAISTLRDFgvgkrg 144 rabbit
Q05555     65 YGPVFTIHlgprRIVVLCgQEAVKEALVDQAEDFSGRGELATFDWLFkGYGVVFSSWERARPLRRFAISTLRDFgvgkrg 144 rabbit
P24454     65 YGPVFTIHlgprPAVMLWgYDAVKEALIDQAEELSDRGEQAFFDWFFkGYGVVFSSGERAKQLRRFSIATLRDFgfgkrg 144 golden hamster
P56593     64 YGPVFTIHlgprRVVVLYgYDAVKEALVDHAEEFSGRGEQATFNTLFkGYGVAFSNGERAKQLRRFSIATLRDFgmgkrg 143 house mouse
P11711     64 YGPVFTIHlgprRVVVLYgYDAVKEALVDQAEEFSGRGEQATYNTLFkGYGVAFSSGERAKQLRRLSIATLRDFgvgkrg 143 Norway rat
P15149     64 YGPVFTIHlgprRIVVLYgYDAVKEALVDQAEEFSGRGELPTFNILFkGYGFSLSNVEQAKRIRRFTIATLRDFgvgkrd 143 Norway rat
Feature 1                                                                                     
2P85_A    123 iEERIQEEAGFLIDALRGThganidPTFFLSRTVSNVISSIVFGDRFDYedKEFLSLLRMMLGSFQFTATSTGqlyemfs 202 human
AUR34092  145 iEERILEEAHFLLESLRATksapfdPTYTLSRTVSNVISSIAFGDRFEYedKEFISLLSMMLGSFQFTATSWGqlydmfs 224 Eremias argus
P20852    145 iEERIQEEAGFLIDSFRKTngafidPTFYLSRTVSNVISSIVFGDRFDYedKEFLSLLRMMLGSFQFTATSMGqlyemfs 224 house mouse
P15392    145 iEERIQEEAGFLIDSFRKTngafidPTFYLSRTVSNVISSIVFGDRFDYedKEFLSLLRMMLGSLQFTATSMGqvyemfs 224 house mouse
Q05556    145 iEERIQEEAGFLIEAFRDTrgafidPTFFLSRTVSNVISSIVFGDRFDYedKEFLSLLRMMLGSFQFTATPTGqlyemfy 224 rabbit
Q05555    145 iEERIQEEAGFLIEAFRDTrgafidPTFFLSRTVSNVISSIVFGDRFDYedKEFLSLLRMMLGSFQFTATPTGqlyemfy 224 rabbit
P24454    145 iEERTIEETSFLIQALRDTngatidPTFYMSRTVSNVISSIVFGNRFEYddKEFLSLLGMIMRSFQFMSTSTGqlfemfy 224 golden hamster
P56593    144 vEERIQEEAGCLIKMLQGTcgapidPTIYLSKTASNVISSIVFGDRFNYedKEFLSLLQMMGQVNKFAASPTGqlydmfh 223 house mouse
P11711    144 vEERILEEAGYLIKMLQGTcgapidPTIYLSKTVSNVISSIVFGERFDYedTEFLSLLQMMGQMNRFAASPTGqlydmfh 223 Norway rat
P15149    144 vQECILEEAGYLIKTLQGTcgapidPSIYLSKTVSNVINSIVFGNRFDYedKEFLSLLEMIDEMNIFAASATGqlydmfh 223 Norway rat
Feature 1                                                                              #  ##  
2P85_A    203 svmkhlpgpQQQAFKELQGLEDFIAKKVEHNqrtldpnspRDFIDSFLIRMqeeeknpntefYLKNLVMTTLNLFFAGTE 282 human
AUR34092  225 dvmqylpgpQQEAFKQLLGLEKFIARKVKANeqtldpnspRDFIDCFLVKMhqekenphsefSLKNLVLTTLAVFFAGTE 304 Eremias argus
P20852    225 svmkhlpgpQQQAFKELQGLEDFITKKVEHNqrtldpnspRDFIDSFLIRMleekknpntefYMKNLVLTTLNLFFAGTE 304 house mouse
P15392    225 svmkhlpgpQQQAFKELQGLEDFITKKVEHNqrtldpnspRDFIDSFLIRMleekknpntefYMKNLVLTTLNLFFAGTE 304 house mouse
Q05556    225 svmkhlpgpQQQAFKELEGLRDFIAKKVERNqrtldpnspRDFIDSFLIRMqeekkdpksefHMKNLVLTTLNLFFAGTE 304 rabbit
Q05555    225 svmkhlpgpQQQAFKELEGLRDFIAKKVERNqrtldpnspRDFIDSFLIRMqeekkdpksefHMKNLVMTTLNLFFAGTE 304 rabbit
P24454    225 svmkhlpgcQHQAYKEMQGLEDFIARKVEENqrtldpnspRDFIDSFLIRMqeekknprtqfHMRNLLMTTLNLFFAGTE 304 golden hamster
P56593    224 svmkylpgpQQQIIKDSHKLEDFMIQKVKQNqstldpnspRDFIDSFLIHMqkeky-vnsefHMKNLVMTSLNLFFAGSE 302 house mouse
P11711    224 svmkylpgpQQQIIKVTQKLEDFMIEKVRQNhstldpnspRNFIDSFLIRMqeekn-gnsefHMKNLVMTTLSLFFAGSE 302 Norway rat
P15149    224 svmkylpgpQQQIIKVTQKLEDFMIEKVRQNhstldpnspRNFIDSFLIRMqeeky-vnsefHMNNLVMSSLGLLFAGTG 302 Norway rat
Feature 1     ##  #                                                  #        ## #            
2P85_A    283 TVSTTLRYGFLLLMKHPEVEAKVHEEIDRvigknrqpkfedrakMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 362 human
AUR34092  305 TISTTLRYGFLLLLKYPEVQEKVHKEIEHvigrnrspnmndrslMPYTDAVIHEIQRFCDIIPMGVSRLVTRDTQFRGYT 384 Eremias argus
P20852    305 TVSTTLRYGFLLLMKHPDIEAKVHEEIDRvigrnrqpkyedrmkMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFRDFL 384 house mouse
P15392    305 TVSTTLRYGFLLLMKYPDIEAKVHEEIDRvigrnrqpkyedrmkMPYTEAVIHEIQRFADLIPMGLARRVTKDTKFRDFL 384 house mouse
Q05556    305 TVSTTMRYGFLLLMKHPDVEAKVHEEIDRvigrnrqpkfedrakMPYTEAVIHEIQRFTDMIPMGLARRVTRDTKFRDFL 384 rabbit
Q05555    305 TVSTTMRYGFLLLMKHPDVEAKVHEEIDRvigrnrqpkfedrakMPYTEAVIHEIQRFTDMIPMGLAHRVTRDTKFRDFL 384 rabbit
P24454    305 TVSTTTRYGFLLLMKYPHIAAKMHEEIDQvigrnrqpkyedhlkMPYTEAVIYEIQRFVDVVPLGLPRSTTKDIKFRDFL 384 golden hamster
P56593    303 TVSSTLRYGFLLLMKHPDVEAKVHEEIDRvigrnrqpqyedhmkMPYTQAVINEIQRFSNFAPLGIPRRITKDTSFRGFF 382 house mouse
P11711    303 TVSSTLRYGFLLLMKHPDVEAKVHEEIEQvigrnrqpqyedhmkMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFF 382 Norway rat
P15149    303 SVSSTLYHGFLLLMKHPDVEAKVHEEIERvigrnrqpqyedhmkMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFF 382 Norway rat
Feature 1               #                                   ###   #####  ##                   
2P85_A    363 LPKGTEVFPMLGSVLrDPRFFsNPRDFNPQHFldkkgqFKKSDafVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRfks 442 human
AUR34092  385 IPKGTEVFPLLGSVLkDPRHFaRPDVFDPRHFldengqFKKNEafMPFSVGKRYCLGENLGRMELFLFFTSILQNFRlks 464 Eremias argus
P20852    385 LPKGTEVFPMLGSVLkDPKFFsNPKDFNPKHFlddkgqFKKNDafVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHfks 464 house mouse
P15392    385 LPKGTEVFPMLGSVLkDPKFFsNPKDFNPKHFlddkgqFKKSDafVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHfks 464 house mouse
Q05556    385 LPKGTEVFPMLGSVLkDPKFFsKPREFYPQHFldekgqFKKSDafMPFSVGKRYCLGEGLARMELFLFFTTIMQNFRfrs 464 rabbit
Q05555    385 LPKGAEVFPMLGSVLkDPKFFsKPREFYPQHFldekgqFKKSDafMPFSVGKRYCLGEGLARMELFLFFTTIMQNFRfrs 464 rabbit
P24454    385 IPKGTDVFPVLSSVLkDPKFFsNPNDFNPQHFsddkgqFKKSNafMPFSVGKRYCFGESLAKMELFIFFTTIMQNFCfks 464 golden hamster
P56593    383 LPKGTEVFPILGSLMtDPKFFsSPKDFNPQHFlddkgqLKKIPafLPFSTGKRFCLGDSLAKMELFLFFTTILQNFRfkf 462 house mouse
P11711    383 LPKGTDVFPILGSLMtDPKFFpSPKDFDPQNFlddkgqLKKNAafLPFSTGKRFCLGDGLAKMELFLLLTTILQNFRfkf 462 Norway rat
P15149    383 LPKGTDVFPIIGSLMtEPKFFpNHKDFNPQHFlddkgqLKKNAafLPFSIGKRFCLGDSLAKMELFLLLTTILQNFRfkf 462 Norway rat
Feature 1                              
2P85_A    443 pqspKDIDVSPKhvgFATIPRNYTM 467 human
AUR34092  465 pvppEKIDITPMlvgFATIPRFYEM 489 Eremias argus
P20852    465 tqapQDIDVSPRlvgFATIPPTYTM 489 house mouse
P15392    465 tqepQDIDVSPRlvgFVTIPPTYTM 489 house mouse
Q05556    465 qqapQDIDVSPKhvgFATIPRTYTM 489 rabbit
Q05555    465 qqapQDIDVSPKhvgFATIPRTYTM 489 rabbit
P24454    465 pqapQDIDVTPQyfsFAAIPPKFTM 489 golden hamster
P56593    463 prklEDINESPTpegFTRIIPKYTM 487 house mouse
P11711    463 pmklEDINESPKplgFTRIIPKYTM 487 Norway rat
P15149    463 pmnlEDINEYPSpigFTRIIPNYTM 487 Norway rat

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