Conserved Protein Domain Family
Cyp2F

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cd20669: Cyp2F 
cytochrome P450 family 2, subfamily F
Cytochrome P450 family 2, subfamily F (CYP2F) members are selectively expressed in lung tissues. They are responsible for the bioactivation of several pneumotoxic and carcinogenic chemicals such as benzene, styrene, naphthalene, and 1,1-dichloroethylene. CYP2F1 and CYP2F3 selectively catalyzes the 3-methyl dehydrogenation of 3-methylindole, forming toxic reactive intermediates that can form adducts with proteins and DNA. The CYP2F subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410762
Aligned: 8 rows
Threshold Bit Score: 812.84
Threshold Setting Gi: 148692257
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #              ##      #   #                
Q8WNE1        62 YGSMYTVHlgprRVVVLSgYQAVKEALVDQGEEFSGRRDFPAFfnftkgNGIAFSNGDRWKVLRRFSIQILRNFgmgkrs 141 western lowland...
EDL24204      52 WGPVFTVWlgplPAVVLCgYEALRDALVLQADAFSGRGAMAVFdrftcgNGIVFSNGPRWHSLRNFALGVLRELgvgrst 131 house mouse
O18809        62 FGAVYTVYlgprRVVVLSgYQAVKEALVDQAEEFSGRGDYPAFfnftkgNGIAFSNGDRWKALRKYSLQILRNFgmgkrt 141 goat
P33267        62 YGSVFTVYlgsrPVIVLSgYQTVKEALVDKGEEFSGRGAYPVFfnftrgNGIAFSDGERWKILRRFSVQILRNFgmgkrs 141 house mouse
P24903        62 YGSMYTVHlgprRVVVLSgYQAVKEALVDQGEEFSGRGDYPAFfnftkgNGIAFSSGDRWKVLRQFSIQILRNFgmgkrs 141 human
XP_003222941  64 YGPVYTIHlgslPCVVLCgYLAVKEALVDQADDFSDRGDFPVFyrftqgNGIAFSNGEKWKILRRFALHTLKNFgmgkss 143 Anolis caroline...
ARO89862      64 YGSVYTIYlgsqPCLVICgYDAMKEALIDQAEEFGGRGDYPVFlnytkgHGIAFNNGERWKELRRFALLTLRNFgmgkrs 143 Andrias davidianus
XP_018085736  71 YGPVFTIYlgprPNVVLYgYKAVKEALVEQADNFSGRGEFEVVhgftkgNGLVFSNGEKWKTLRRFTLTTLRNFgmgkrg 150 Xenopus laevis
Feature 1                                                                                        
Q8WNE1       142 iEERILEEGSFLLAELRKTegepfDPTFVLSRSVSNIICSVLFGSRFDYddERLLTIIRHINDNFQIMSSPWgelydifp 221 western lowland...
EDL24204     132 iEDRILEEAACVLDEFQATmgapfDPQQLLDSAVSNVICTVVFGKRYDYgdPEFRRLLNLFSDNFCIMSSRWaeiynmfp 211 house mouse
O18809       142 iEERILEEGHFLLEELRKTqgkpfDPTFVVSRSVSNIICSVIFGSRFDYddDRLLTIIHLINENFQIMSSPWgemynifp 221 goat
P33267       142 iEERILEEGSFLLEVLRKMegkpfDPVFILSRSVSNIICSVVFGSRFDYddERLLTIIHFINDNFKIMSSPWgemynifp 221 house mouse
P24903       142 iEERILEEGSFLLAELRKTegepfDPTFVLSRSVSNIICSVLFGSRFDYddERLLTIIRLINDNFQIMSSPWgelydifp 221 human
XP_003222941 144 iEARIQEEAQCLVQEFQKTdgapfNPINLVCRAVSNVICAVVFGNRFDYedADFLRLLDHFNENFQIMSSFWgelynifp 223 Anolis caroline...
ARO89862     144 vEERIQEEAQYLVKEFRNTkmaptDPTVFFSRTVSNIICSIVFGSRFDYedKRLLTIVNSINDNFLIMSTTWgtlynvys 223 Andrias davidianus
XP_018085736 151 vEERIKEEAQFLMEGLKHTkqtpfDPTFFLSRAVSNVICSIVFGERFDYgdKRFLMLLSLINENFQLLSSQWgtfynifp 230 Xenopus laevis
Feature 1                                                                                 #  ##  
Q8WNE1       222 slldwvpgpHQRIFQNFKCLRDLIAHSVHDHqasldprspRDFIDCFLTKMaeenedplshfHMDTLLMTTHNLLFGGTE 301 western lowland...
EDL24204     212 sfmdwipgpHNRIFKNFQELRLFISEQIQWHwqsrqtgepRDFIDCFLDQMdkeqqdleshfQDETLVMTTHDLFFGGTE 291 house mouse
O18809       222 nlldwvpgpHRRLFKNYGRMKNLIARSVREHqasldpnspRDFIDCFLTKMaqekqdplshfFMDTLLMTTHNLLFGGTE 301 goat
P33267       222 svldwipgpHKRLFRNFGGMKDLIARSVREHqdsldpnspRDFIDCFLTKMaqekqdplshfNMDTLLMTTHNLLFGGTE 301 house mouse
P24903       222 slldwvpgpHQRIFQNFKCLRDLIAHSVHDHqasldprspRDFIQCFLTKMaeekedplshfHMDTLLMTTHNLLFGGTK 301 human
XP_003222941 224 hvmdllpgpHHKIFQNFEKLRHFITERIRLHqkdldpeapRDFIDCFLIRMeeekqdplsyfNMETLVMTTHNLFFGGTE 303 Anolis caroline...
ARO89862     224 gvmdylpglHQRIAVNFEKIREVILDGRKTHlethdpncpRDYMDCFITKMaeekknpsnvfYEKSLIMSIQNLLFGGTE 303 Andrias davidianus
XP_018085736 231 gvmkylpgpHKRIFQNFEKMKFFVLDILKSHketfqqdcpRDLMDCFLVEMqkesgkplshfNIETLVMTTLTLFFGGTE 310 Xenopus laevis
Feature 1        ##  #                                                  #     #   # #            
Q8WNE1       302 TVGTTLRYAFLALMKYPKVQARVQEEIDLVVGrarlpalkdraaMPYTDAVIHEVQRFADIIPMSLPHRVTRDTAFRGFL 381 western lowland...
EDL24204     292 TTSTTLRYGLLIMLKYPEVAAKVQEELDATVGrtwapriedrarLPYTNAVLHEIQRFISVLPLGLPRALTRDVNLKNHF 371 house mouse
O18809       302 TVGTTLRHAFRLLMKYPEVQVRVQEEIDRVVGrerlptvedraeMPYTDAVIHEVQRFADIIPMSLPHRVTRDTNFRGFT 381 goat
P33267       302 TVGTTLRHAFLILMKYPKVQARVQEEIDRVVGrsrmptledrtsMPYTDAVIHEVQRFADVIPMNLPHRVTRDTPFRGFL 381 house mouse
P24903       302 TVSTTLHHAFLALMKYPKVQARVQEEIDLVVGrarlpalkdraaMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFL 381 human
XP_003222941 304 TTSTTLRFSFLILMKYPDVAVRVHQEIDGVIGtnrtpcladrksMPYTDAVIYEIQRFISILPMGLPRAVTRDTPFKEFL 383 Anolis caroline...
ARO89862     304 TVSTTLRYGFLILMKYPKIAEKMQEEIDCVVGhdrspsiedrskMPYTDAVIHEIQRYGDVIPLSLPHVVTCNTTFRGYA 383 Andrias davidianus
XP_018085736 311 TVSTTLRYGILILMKYPDVTEKIQEEIHRVIGknrfptvddrsrMPYTDAVIHEIQRFTSIIPLSLPHAVTQDTYFRGYK 390 Xenopus laevis
Feature 1                  #                                   ###   # ###  ##                   
Q8WNE1       382 IPKGTDIITLLNTVHyDPSQFlTPQEFNPEHFldanqsFKKSPafMPFSAGRRLCLGESLARMELFLYLTAILQSFSlqp 461 western lowland...
EDL24204     372 LHKGTFVIPLLVSAHrDPTQFkDPDHFNPTNFlddhgeFQNNDafMPFALGKRMCLGAGLARSEIFLFLTAILQKFSllp 451 house mouse
O18809       382 IPRGTDVITLLNTVHyDPSQFlKPKEFNPEHFldanmsFKKSPafMPFSAGRRLCLGEALARMELFLYLTAILQSFSlqp 461 goat
P33267       382 IPKGTDVITLLNTVHyDSDQFkTPQEFNPEHFlddnhsFKKSPafMPFSAGRRLCLGEPLARMELFIYFTSILQNFTlqp 461 house mouse
P24903       382 IPKGTDVITLLNTVHyDPSQFlTPQEFNPEHFldanqsFKKSPafMPFSAGRRLCLGESLARMELFLYLTAILQSFSlqp 461 human
XP_003222941 384 LPKGTNVIPLLSSVHyDPTQFkDPMSFNPDHFldekstFKNTDafMPFAPGKRICLGAGLARMEIFLFLTTILQHFSlqp 463 Anolis caroline...
ARO89862     384 IPKGTHVIPLLTSVHyDVTHFkNPQAFDPQNFmddkgsFKKNDalMPFGAGKRICLGESLARMELFLYFTTILQNFTfkp 463 Andrias davidianus
XP_018085736 391 LPKGTNVIPVLTSVHtDPTKYkEPQRFDPHNFldennqFKSNEafMPFSSGKRICVGESLARMELFIFFSTLLQNFTfqp 470 Xenopus laevis
Feature 1                                 
Q8WNE1       462 lgapKDIDLTPLssgLGNLPRPFQL 486 western lowland gorilla
EDL24204     452 vgspANINLNPQctgLGNVPPAFQL 476 house mouse
O18809       462 lgapEDIDLTPLssgLGNVPRPYQL 486 goat
P33267       462 lvdpEDIDLTPLssgLGNLPRPFQL 486 house mouse
P24903       462 lgapEDIDLTPLssgLGNLPRPFQL 486 human
XP_003222941 464 lvapAEIDLTPQctgLGNVPRPFQF 488 Anolis carolinensis
ARO89862     464 lvrpEEIDLTPTgsgLGNVPPHYKC 488 Andrias davidianus
XP_018085736 471 tqqpELIDLKPTisgVGNVPTPYQL 495 Xenopus laevis

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