3RUK,4NKV,4R20,6B82


Conserved Protein Domain Family
CYP17A1

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cd20673: CYP17A1 
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cytochrome P450 family 17, subfamily A, polypeptide 1
Cytochrome P450 17A1 (CYP17A1 or Cyp17a1), also called cytochrome P450c17, steroid 17-alpha-hydroxylase (EC 1.14.14.19)/17,20 lyase (EC 1.14.14.32), or 17-alpha-hydroxyprogesterone aldolase, catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. It is a dual enzyme that catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reactions. Severe mutations on the enzyme cause combined 17-hydroxylase/17,20-lyase deficiency (17OHD); patients with 17OHD synthesize 11-deoxycorticosterone (DOC) which causes hypertension and hypokalemia. Loss of 17,20-lyase activity precludes sex steroid synthesis and leads to sexual infantilism. Included in this group is a second 17A P450 from teleost fish, CYP17A2, that is more efficient in pregnenolone 17-alpha-hydroxylation than CYP17A1, but does not catalyze the lyase reaction. CYP17A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410766
Aligned: 25 rows
Threshold Bit Score: 778.424
Threshold Setting Gi: 742261332
Created: 17-Jul-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #         #               ##       #   #             
3RUK_A        42 YGPIYSVRmg-tkTTVIVGhHQLAKEVLIKKgkDFSGRPQMATLDIAsnnrkGIAFADSGAHWQLHRRLAMATFalfkdg 120 human
6B82_A        57 YGDLYSLMmg-shKLLIVNnHHHAKEILIKKgkIFAGRPRTVTTDLLtrdgkDIAFADYSSTWKFHRKMVHGALcmfgeg 135 zebrafish
AAG42003      66 YGSLYSFRmg-shYIVIVNhHEHAKEVLLKKgkTFGGRPRAVTTDILtrnakDIAFANYSPSWKFHRKVVHAALsmfgeg 144 African clawed ...
ABU54401      67 YGPLFGLYag-phLTLVVSeIGLVREVLLQRgrEFAGRPKMVTTDLLtqggkDIAFADYSPLWKNHRRLVHSSFtlfgeg 145 zebrafish
O73853        65 YGDIYSLDmg-snRVIIVNnHHHAKEVLLRKgkIFAGRPRTVTTDILtrdgkDIAFGDYSATWKFHRKIVHGALcmfgeg 143 channel catfish
Q92113        65 YGNLFSLMmg-phYAVVINnHQHAKEVLLKKgkIFAGRPSMVTTDLLsrggkDIAFGKYGPAWKFHRKLVLSALhlfgdg 143 spiny dogfish
XP_006629247  66 YGELFALYvgphyTVVVNS-FTLAKEVLLHNgkAFAGRPHMMTTDLLsrggkDIAFADYSPLWKAHRRLVHSSFvasgeg 144 spotted gar
P30437        66 YGHTYSLMmg-phTVILVNhHQHAKEVLLKKgkIFAGRPRTVTTDLLtrdgkDIAFADYGATWRFHRKTVHGALcmfgeg 144 rainbow trout
O57525        74 YGSLYSFMmg-shYVVVVNnHEDAREVLLKKgkTFGGRPRTVTTDILtrdgkDIAFADYSPTWKFHRKMVHSALcmfgeg 152 Rana dybowskii
P70085        65 YGQTYSLKmg-shQVIIVNhHAHAREVLLKRgrTFAGRPRTVTTDVLtrdgkDIAFGDYSATWRFHRKIVHGALcmfgeg 143 Japanese medaka
Feature 1                                                                                        
3RUK_A       121 dqKLEKIICQEISTLCDMLATHngq--sidISFPVFVAVTNVISLICFNtsykngdPELNVIQNYNEGIIDNLSkdslvd 198 human
6B82_A       136 svSIEKIICREASSMCEVLTESqns--avdLGPELTRAVTNVVCALCFNssykrgdAEFESMLQYSQGIVDTVAkdslvd 213 zebrafish
AAG42003     145 tvAIEKIISREATSLCQSLISFqdn--pldMAPELTRAVTNVVCALCFNtrykrcdPEFEEMLAYSKGIVDTVAkdslvd 222 African clawed ...
ABU54401     146 snKLQTIVQEAADSLCEELQACrgq--ssdLSVVLMRAVTNVICRLVFSssyqpsdPELQTVIQYNDGIVQTIArgglvd 223 zebrafish
O73853       144 taSIEKIICREASSMCEILTNLqss--aadLAPELTRAVTNVVCTLCFSssykrgdPEFEAMLKYSQGIVDTVAkdslvd 221 channel catfish
Q92113       144 saGIEKMICQEATSMCSTFERLnna--ahdMMPDVTRAVTNVICLLCFNstyekedPEFQTMRKYSQGIVNTVAkdslid 221 spiny dogfish
XP_006629247 145 ssKLQGIVCEEASILCSILSAKage--pldPGPVLTRAVTNVVCTLVFSskyhpedAEFNTVMEYNNGIVHTIArgnlvd 222 spotted gar
P30437       145 saSIEKIICREALSLCDTLRESgsa--sldLSPELTRAVTNVVCSLCFSssycrgdPEFEAMLQFSQGIVDTVAkdslvd 222 rainbow trout
O57525       153 tvAIEQIISREAASLCQTLTSFqri--pldMAPELIRAVTNVVCSLCFNtrykrgdAEFETMLKYSKGIVDTVAkdslvd 230 Rana dybowskii
P70085       144 saSLQRIICTEAQSLCSTLSEAaatglaldLSPELTRAVTNVICSLCFNssysrgdPEFEAMLRYSQGIVDTVAkdslvd 223 Japanese medaka
Feature 1                                                                                        
3RUK_A       199 lvpwlkifPNKTLEKLKSHVKIRNDLLNKILENYkekfrsdsiTNMLDTLMQAKmnsdngna--gpdqdselLSDNHILT 276 human
6B82_A       214 ifpwlqifPNKDLRILRQCISIRDKLLQKKYEEHkvtysdnvqRDLLDALLRAKrssennn----sstrdvgLTEDHVLM 289 zebrafish
AAG42003     223 ifpwlqifPNKDLDILKRSVAIRDKLLQKKLKEHkeafcneevNDLLDALLKAKlsmennns---nisqevgLTDDHLLM 299 African clawed ...
ABU54401     224 ifpwlrifPNKDLKRLKECVSIRDQLLYKKLLEHkksltpgepRDLLDALLIGQqrgsg---------gaddITEDHVLM 294 zebrafish
O73853       222 ifpwlqlfPNEDLRILRRCVSIRDKLLQKKYEEHkadfsdniqRDLFDALLRAKnssennn----tstqdvgLTDDHLLM 297 channel catfish
Q92113       222 ifpwlqffPNENLHTLKQCIATRDSILQKKFEDHkanyssdsaNDLFNILLKAKmnaennn----ssvheagLTDDHMVM 297 spiny dogfish
XP_006629247 223 ifpwlkifPNRDLKQLKECIQVRDKLLTNKLEEHkksyspddtRDLMDVLLKGRngpg----------aesgITDDHVLM 292 spotted gar
P30437       223 ifpwlqvfPNADLRLLKQCVSIRDKLLQKKYEEHksdysdheqRDLLDALLRAKrsaennnta-eitmetvgLSEDHLLM 301 rainbow trout
O57525       231 ifpwlqifPNKDLDILRQSVAARDQLLQKKINEHkdafcgetvKDLVDALLKAKlnmennns---nvsqdvgLTEDHILM 307 Rana dybowskii
P70085       224 ifpwlqifPNKDLRLLKQCVAVRDQLLQKKFEEHksdysdhvqRDLLDALLRAKrsaennntaaefsaeavgLSDDHLLM 303 Japanese medaka
Feature 1           ##  ##  ##  #                                                       #   #  # 
3RUK_A       277 TIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGfsrtptisdrNRLLLLEATIREVLRLRPVAPMLIPHK 356 human
6B82_A       290 TVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGkerhpqlsdrGNLPYLEATICEVMRIRPVSPLLIPHV 369 zebrafish
AAG42003     300 TVGDIFVAGVETTTTVLKWTMAYLLHYPEVQTKIQEELDFKVGfgrhpvlsdrRILPYLDATISEVLRIRPVAPLLIPHV 379 African clawed ...
ABU54401     295 TAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGvdrppclsdrPHLPLLDAVLCEVMRIRPVSPILIPHV 374 zebrafish
O73853       298 TVGDIFGAGVETTTTVLKWSILYLIHHPQVQRKIQEELDAKIGrdrhpqvndrGNLPYLEATIREVLRIRPVSPLLIPHV 377 channel catfish
Q92113       298 TVADIFGAGVETSSTAFAWMIIYLIHHPEVQKKIQEEIDSNIGfertpkmsdkGNMNFLNATIHEILRIQPVSPLLIPHV 377 spiny dogfish
XP_006629247 293 TAAEAFGAGVETTSTTLLWALAFLIHYPEVQKKIHQEIDEKIGhdrtpnlsdrGQLPYLESTLSEVLRIRPVAPLLIPHV 372 spotted gar
P30437       302 TVGDIFGAGVETTSTVLKWAIAYLIHHPQVQQRIQEELDSVVGgdrtpqlsdrGSLPYLEATIREVLRIRPVAPLLIPHV 381 rainbow trout
O57525       308 TVGDIFGAGVETTSTVLKWAVAYLLHYPEVQKKIQEELDVKVGfgrypllsdrKILHYTEAAISEVLRIRPVSPLLIPHV 387 Rana dybowskii
P70085       304 TVGDIFGAGVETTTTVLKWAITYLIHYPEVQKQIQEELDRKVGvdrppqlsdrGSLPFLEATIREVLRIRPVAPLLIPHV 383 Japanese medaka
Feature 1                                                                   ###   #####   #      
3RUK_A       357 ANVDSSIGEFAVDKGTEVIINLWALHhNEKEWhQPDQFMPERFlnpagtqlispsvsYLPFGAGPRSCIGEILARQELFL 436 human
6B82_A       370 ALQDSSVGEYTVQKGTRVVINMWSLHhDEKEWkNPELFDPGRFlneegdglccpsgsYLPFGAGVRVCLGEALAKMELFL 449 zebrafish
AAG42003     380 ALQESSIAEYTIPQDARVVINLWSLHhDPNEWeNPEEFNPERFldengnhvyspsqsYLPFGAGIRVCLGEALAKMEVFL 459 African clawed ...
ABU54401     375 AMQDTSLGGHSVPKGTRVLVNMWAIHhDPKHWdQPEQFNPERFlepsgk--kktqssFLPFGAGPRVCVGESLARIELFL 452 zebrafish
O73853       378 ALSDANIGEYTVQKGTRVIVNLWSLHhDEKEWkNPELFNPERFlneegnslccpslsYLPFGAGVRVCLGEALAKLELFL 457 channel catfish
Q92113       378 ALADSSIGDYTIPKGTRVIINLWAIHhDEKEWkNPDAFDPGRFldedgkyvcsssesYLPFGAGTRVCLGEMLARMELFL 457 spiny dogfish
XP_006629247 373 ALQDTSIGEHFIPKDTRVVVNMWSIHhDPRQWdEPERFRPERFldsqgq--rsspasFIPFGAGPRVCVGESLAKMELFL 450 spotted gar
P30437       382 AQTDTSIGKFTVRKGARIIINLWSLHhDEKEWkNPEMFDPGRFlneegtglcipspsYLPFGAGVRVCLGEALAKMEIFL 461 rainbow trout
O57525       388 ALKESSIGEYTIPKEARVVINLWSLHhDEKEWvNPHLFSPDRFldengnrvyspspsFLPFGAGIRVCLGEALAKMEVFL 467 Rana dybowskii
P70085       384 ALSDTSLGDFTVRKGTRVVINLWSLHhDEKEWtNPDLFNPGRFlsadgssltlpsssYLPFGAGLRVCLGEALAKMELFL 463 Japanese medaka
Feature 1                                             
3RUK_A       437 IMAWLLQRFDLevpddgQLPSLEGipKVVFLIDSFKV 473 human
6B82_A       450 FLAWILQRFTLemptgqPLPDLQGkfGVVLQPKKFKV 486 zebrafish
AAG42003     460 FLSWILQRFTLelpagdSLPDLDGkfGVVLQVKKFRV 496 African clawed frog
ABU54401     453 FVSRPLQRFSFscpseaSLPDLQGrfGVVLQPERYTV 489 zebrafish
O73853       458 FLSWILQRFTLevpggqPLPELQGkfRVVLQPQKYKV 494 channel catfish
Q92113       458 FTSWILQRFTVqvppgyPPPDKEGkfGIVLQPLKFKV 494 spiny dogfish
XP_006629247 451 FSSWLLQRFSVsgppgaGLPDLGGryGVVLQPQPYSV 487 spotted gar
P30437       462 FLSWILQRLTMtvspgqPLPSLEGkfGVVLQPVKYKV 498 rainbow trout
O57525       468 FLSWILQRFTLevpegdPLPDLEGkfGVVIQVKPFKV 504 Rana dybowskii
P70085       464 FLSWILQRFTLsvppsqSLPSLEGkfGVVLQPVKYAV 500 Japanese medaka

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