2HI4,4I8V,6DWN,6DWM


Conserved Protein Domain Family
CYP1A

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cd20676: CYP1A 
Click on image for an interactive view with Cn3D
cytochrome P450 family 1, subfamily A
Cytochrome P450 family 1, subfamily A (CYP1A) consists of two human members, CYP1A1 and CYP1A2, which overlap in their activities. CYP1A2 is the highly expressed cytochrome enzyme in the human liver, while CYP1A1 is mostly found in extrahepatic tissues. Known common substrates include aromatic compounds such as polycyclic aromatic hydrocarbons, arachidonic acid and eicosapentoic acid, as well as melatonin and 6-hydroxylate melatonin. In addition, CYP1A1 activates procarcinogens into carcinogens via epoxides, and metabolizes heterocyclic aromatic amines of industrial origin. CYP1A2 metabolizes numerous natural products that result in toxic products, such as the transformation of methyleugenol to 1'-hydroxymethyleugenol, estragole to reactive metabolites, and oxidation of nephrotoxins. It also plays an important role in the metabolism of several clinical drugs including analgesics, antipyretics, antipsychotics, antidepressants, anti-inflammatory, and cardiovascular drugs. The CYP1A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410769
Aligned: 29 rows
Threshold Bit Score: 878.577
Created: 18-Jul-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #               #        #   #              
2HI4_A        48 YGDVLQIRIGstPVLVLSrLDTIRQALVRQGDDFKGRPDLYTstlITDGQSLTFSTdsgpVWAARRRLAQNALNTFsias 127 human
AAL54873      75 YGPVFQIQIGmrPVVVLSgNDVIRQALLKQGEEFSGRPELYStkfISDGKSLAFSTdqvgVWRARRKLALNALRTFstvq 154 zebrafish
Q92116        75 YGDVFQIQIGmrPVVVLSgSETVRQALIKQGDXFAGRPDLYSfrfINDGKSLAFSTdqagVWRARRKLAYSALRSFatle 154 Stenotomus chry...
O42231        75 YGNVFQIQIGmrPVVVLSgNETVRQALIKQGDEFAGRPDLYSfrfISEGKSLAFSTdqagVWRARRKLAYSALRSFstle 154 golden grey mullet
Q92109        75 YGSVFQIQIGmrPVVVLSgNETVRQALIKQGEDFAGRSDLYSfkfINDGKSLAFSTdkagVWRARRKLAMSALRSFatle 154 rainbow trout
Q92110        75 YGSVFQIQIGmrPVVVLSgNETVRQALIKQGEDFAGRPDLYSfkfINDGKSLAFSTdkagVWRARRKLAMSALRSFatle 154 rainbow trout
ADM47615      78 YGDIFQIQIGtrPVLVLSgLDTLKQALVKQGDDFAGRPSLYSfkfINNGKSLTFSSdyseVWRLRRKLAQNALRTFstee 157 little skate
XP_005994149  72 YGDVLQIQIGtrPVVVLSgLNTLKQALIKKGDDFIGRPALYSfqfISNGNSLTFNTdlgdVWSARKKLAQSALRIFstde 151 coelacanth
XP_007907324  81 YGDVFQVQIGsrTVVVLSgIHTLRQALVKQADDFAGRPDLPSfryISDGNSLAFGNdysdVWRARRKLAQSALRTFsade 160 elephant shark
XP_029430341  78 YGDVMQIQIGtrPVLVLSgLDTLKQALIKQGEDFLGRPHLHTfslIGDGQTLTFSSdsgeIWKIRRSFVQNALRTFstsp 157 two-lined caeci...
Feature 1                                                                                        
2HI4_A       128 dpasssscyLEEHVSKEAKALISRLQELmagpghfdPYNQVVVSVANVIGAMCFGQhfpessDEMLSLVKNTHEFVETAS 207 human
AAL54873     155 gkspkyscaLEEHISNEGLYLVQRLHSVmkadgsfdPFRHIVVSVANVICGICFGRrhshddDELVRLVNMSDEFGKIVG 234 zebrafish
Q92116       155 gttpeyscaLEEHVSKEAEYLVKQLHTVmeadgsfdPFRHIVVSVANVICGMCFGRrydhnhQELLNLVNLSDEFGQVVA 234 Stenotomus chry...
O42231       155 gttpeyscvLEEHISKEAEYLIKQLDTVmkadgsfdPFRYIVVSVANVICGMCFGRrydhhdRELLSLVNLSDEFGQVVG 234 golden grey mullet
Q92109       155 gttpeyscaLEEHVLKEGEYLVKQLTSVmdvsgsfdPFRHIVVSVANVICGMCFGRryshddQELLGLVNMSDEFGQVVG 234 rainbow trout
Q92110       155 gttpeyscaLEEHVCKEGEYLVKQLTSVmdvsgsfdPFRHIVVSVANVICGMCFGRryshddQELLGLVNMSDEFGQVVG 234 rainbow trout
ADM47615     158 wknsthsclLEEHVCSEARHLIQIFVEQmkrrgsfdPMRYIVVSVANVICALCFGKryshedQELLNIVNVSDEFGKIVA 237 little skate
XP_005994149 152 skdttyssvLEEHVSKEAKYLVTKLMDImktngsfePFRYTVVSVANVICALCFGKryshddQELLSCVNMSKEFGTVAA 231 coelacanth
XP_007907324 161 cknsthscvLEEHTCKEAQQLVEVLLERaeg---fdPVRYIVISVANVICAMCFGKryshddQKLLEVVNLTDEFGKVAG 237 elephant shark
XP_029430341 158 catstcsclIEEHICKEAEYLVTKFLKLmeergsfdPFRYLVVSVANVVSAMCYGRryshddQELLSLVNLTNEFGKAAG 237 two-lined caeci...
Feature 1                                                                                        
2HI4_A       208 SGnpldffpilrylpnPALQRFKAFNQRFLWFLQKTVQEHyqdfdknsvRDITGALFKHSkkgpr--asgnlIPQEKIVN 285 human
AAL54873     235 SGnpadfipflrilpsTTMKKFLDINERFSKFMKRLVMEHydtfdkdniRDITDSLINHCedrkldensnlqVSDEKIVG 314 zebrafish
Q92116       235 SGnpadfipilqylpsTTMKKFLNINDRFNTFVQKIVSEHyttfdkdniRDITDSLIDHCedrkldensnvqMSDEKIVG 314 Stenotomus chry...
O42231       235 SGnpadfipilqylpnKTMKKFVNINDRFISFVQKIVSEHyatfnkdniRDITDSLIDHCedrkldenanvqMSDEKVVG 314 golden grey mullet
Q92109       235 SGnpadfipilrylpnRTMKRFMDINDRFNNFVQKIVSEHyesydkdniRDITDSLIDHCedrkldenaniqVSDEKIVG 314 rainbow trout
Q92110       235 SGnpadfipilrylpnRTMKRFMDINDRFNNFVQKIVSEHyesydkdniRDITDSLIDHCedrkldenaniqVSDEKIVG 314 rainbow trout
ADM47615     238 AGnpadfipilrflpnHSMDKFIAINKRFATFVENIVMEHyrtfdkdniRDITDSLIGHCqdkkvdenaniqISDEKIVG 317 little skate
XP_005994149 232 SGnpadfipilrflpnRTLRRFIDLNNRFNAFIQKIVQQHyktfdkdniRDITDSLINHCqdkkmdenanihMSDEKIVT 311 coelacanth
XP_007907324 238 AGnlsdfipvlrfipnPTMAAFLEANKKFMSFLKSIVNEHyqtfdkdniRDITDSLIEHCqdkkmdenaniqVSDEKIIN 317 elephant shark
XP_029430341 238 SGnlvdfipmlrylpsQTMKAFVDVNKRFQVFVQKIVNEHyksfdknniRDITDSLIDQCqekkvdenaniqISSQKIVN 317 two-lined caeci...
Feature 1            #  ##  ##                                                          ##  ## # 
2HI4_A       286 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGrerrprlsDRPQLPYLEAFILETFRHSSFLPFTIPHS 365 human
AAL54873     315 IVNDLFGAGFDTISTALSWAVVYLVHYPEVQERLQRELDEKIGkdrtpllsDRANLPLLESFILEIFRHSSFLPFTIPHC 394 zebrafish
Q92116       315 IVNDLFGAGFDTISTALSWSVMYLVAYPEIQERLYQEMNETVGpdrtpclsDKPKLPFLEAFILETFRHSSFLPFTIPHC 394 Stenotomus chry...
O42231       315 IVNDLFGAGLDTISTALSWSVMYLVAYPEIQERLYQELKENVGldrtpvlsDRNNLPLLEAFILEIFRHSSFLPFTIPHC 394 golden grey mullet
Q92109       315 IVNDLFGAGFDTISTALSWAVVYLVAYPETQERLHQELKEKVGmirtprlsDKINLPLLEAFILEIFRHSSFLPFTIPHC 394 rainbow trout
Q92110       315 IVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQELKEKVGmirtprlsDKINLPLLEAFILEIFRHSSFLPFTIPHC 394 rainbow trout
ADM47615     318 IVNDLFGAGFDTITTAVSWCVMYLVYYPDIQKKLHEEIDETIGkdrspritDKPSLPYTEAFIMETFRHSSFLPFTIPHC 397 little skate
XP_005994149 312 IVNDLFGAGFDTITTALCWNFMYLASYPDIQKKIHKELDEVIGrerrprfsDRSVLPYTDAFIYETFRHSSFLPFTIPHC 391 coelacanth
XP_007907324 318 IVNDLFGAGFDTITTGLSWAVMYLVLYPDLQKRLQDEIDEKIGkdrsprlsDRSRLPYTDAFILETFRYSSFLPFTIPHC 397 elephant shark
XP_029430341 318 LVNDVFGAGFDTITTALSWSLVYLVTLKDIQQKIHEELDQVIGrerrprlsDRPLLPYMEAFIMEMLRHSSFVPLTIPHC 397 two-lined caeci...
Feature 1                             #                                      ##    # ###   #     
2HI4_A       366 TTRDTTLNGFYIPKKCCVFVNQWQVNhDPELWeDPSEFRPERFLtadGTAINKPLSekmMLFGMGKRRCIGEVLAKWEIF 445 human
AAL54873     395 TSKDTSLNGYFIPKDTCVFVNQWQVNhDPELWkDPSSFIPDRFLtadGTELNKLEGekvLVFGLGKRRCIGESIGRAEVF 474 zebrafish
Q92116       395 TSKDTSLNGYFIPKDTCVFINQWQINhDAELWkDPSSFNPDRFLnadGTEVNKLEGekmMVFGMGKRRCIGEVIARSEVF 474 Stenotomus chry...
O42231       395 TTKDTSLNGYYIPKDTCVFINQWQINhDPELWkEPSSFNPDRFLsadGTEVNKVDGekvMVFGLGKRRCIGEVIARNEVY 474 golden grey mullet
Q92109       395 TIKDTSLNGYFIPKDTCVFINQWQVNhDPELWkEPSSFNPDRFLsadGTELNKLEGekvLVFGMGKRRCIGEAIGRNEVY 474 rainbow trout
Q92110       395 TIKDTSLNGYFIPKDTCVFINQWQVNhDPELWkEPSSFNPDRFLsadGTELNKLEGekvLVFGMDKRRCIGEAIGRNEVY 474 rainbow trout
ADM47615     398 TTKDTALNGYYISKNTCVFVNQWQVNhDSSLWkDPFAFRPERFLnadGKTTNKVECekvLLFGMGKRRCIGEAIGRIEVF 477 little skate
XP_005994149 392 TVRDTAVNGYFIPKNTCIFINQWQVNhDPKLWeDPSAFCPERFLnkdQISLCKTETekiMTFGMGKRRCIGESIGRSQVF 471 coelacanth
XP_007907324 398 TTKDTALNGYFIPKNTCVFVNQWQVNhDEKLWtDPFTFNPDRFLnadGASINKMESekvLLFGMGKRRCIGESIGRIEVF 477 elephant shark
XP_029430341 398 TTRATSLNGYHIPKGMCIFVNQWHVNhDEKLWkDPFTFNPERFLnadRNGLNKTEAekvVTFGLGKRKCIGENIARLEMF 477 two-lined caeci...
Feature 1                                             
2HI4_A       446 LFLAILLQQLEfsvpPGVKVDLTPIYGLTMKHARCEH 482 human
AAL54873     475 LFLAILLQRLKftgmPGEMLDMTPEYGLTMKHKRCLL 511 zebrafish
Q92116       475 LFLAILVQNLRfhsmPGEPLDMTPEYGLTMKHKRCQL 511 Stenotomus chrysops
O42231       475 MFLAILIQKLHfynlPGEPLDMTPEYGLTMKHKRCHL 511 golden grey mullet
Q92109       475 LFLAILLQRLRfqekPGHPLDMTPEYGLTMKHKRCQL 511 rainbow trout
Q92110       475 LFLAILLQRLRfqekPGHPLDMTPEYGLTMKHKRCQL 511 rainbow trout
ADM47615     478 LFLTSLVQQLQfekkPGQDIDMTPQYGLTMKPKRCEV 514 little skate
XP_005994149 472 LFLIVLLQHLEfyaaPGQVLDMTPEYGLTMKYKRCDL 508 coelacanth
XP_007907324 478 LFFTTLVQQLHfdniPGQEIDTTPIYGLTMKHKKCEF 514 elephant shark
XP_029430341 478 LFLATLLQQLEfdmkDGEKLDMSAEYGLTLKHKRCEL 514 two-lined caecilian

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