5T6Q,6C94


Conserved Protein Domain Family
CYP4B-like

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cd20678: CYP4B-like 
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cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z
This group is composed of family 4 cytochrome P450s from subfamilies A (CYP4A), B (CYP4B), T (CYP4T), X (CYP4X), and Z (CYP4Z). The CYP4A, CYP4X, and CYP4Z subfamilies are specific to mammals, CYP4T is present in fish, while CYP4B is conserved among vertebrates. CYP4As are known for catalyzing arachidonic acid to 20-HETE (20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid), and some can also metabolize lauric and palmitic acid. CYP4Bs specialize in omega-hydroxylation of short chain fatty acids and also participates in the metabolism of exogenous compounds that are protoxic including valproic acid (C8), 3-methylindole (C9), 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and several aromatic amines. CYP4X1 is expressed at high levels in the mammalian brain and may play a role in regulating fat metabolism. CYP4Z1 is a fatty acid hydroxylase that is unique among human CYPs in that it is predominantly expressed in the mammary gland. Monophyly was not found with the CYP4T and CYP4B subfamilies, and further consideration should be given to their nomenclature. The CYP4B-like group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410771
Aligned: 35 rows
Threshold Bit Score: 789.935
Threshold Setting Gi: 1050382777
Created: 20-Sep-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   #    #          ##      #   #      # 
5T6Q_A        45 LDKVVTWTQQFPYAHPLWVGqfIGFLNIYEPDYAKAVYSRGDPKapdvYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFH 124 rabbit
NP_954686     67 LEKIVKWMELYQFAFPLWFGpsLAVLNIHHPSYVKTILTTTEPKddyaYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFH 146 Danio rerio
P15128        62 LDKVVTWTQQFPYAHPLWVGqfIGFLNIYEPDYAKAVYSRGDPKapdvYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFH 141 rabbit
OCT84974     293 MDRVLAWADKYPKAFPMWVGqfFANLIITNPEYAKAVFARSDPKtptgYNFLIPWIGKGLLVLSGDKWFQHRKLLTPGFH 372 African clawed ...
NP_001316438  68 LEKAEAWALKYQHAHPIWFGgfSAVLVINDPEYAKALFARGDPKdnlsYKHLIPWIGNGLLILHGPKWHQHRKLLTPGFH 147 chicken
OCT84972      70 LDRLLNWGLQYPYANPVWFGkfVVYMNITHPEYAKALLSRTDPKdtitYHHLISWIGKGLSVLSGQIWDKHRKLLTSSFH 149 African clawed ...
AGN04302      75 LARGVKWGKQYPYAFPMWFGpsVCFLNIHHPDYAKTILTSTEPKddlvYRFIESWIGNGLLVSKGEKWFRHRRLLTPGFH 154 Indian medaka
AAI29578      69 LDLILKWAQVYPYGVSMWLGnfHAALFLTHPDYAKAILARQDPKdetaYKYIVPWIGEGLLVLSGPKWFQHRRLLTPGFH 148 African clawed ...
Q64462        67 LDKVVTWTEQFPYAHPLWLGqfIVFLNIYEPDYAKAVYSRGDPKaayvYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFH 146 house mouse
P15129        67 LDKVVSWAQQFPHAHPLWFGqfVGFLNIYEPDYAKAVYSRGDPKaadvYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFH 146 Norway rat
Feature 1                                                                                        
5T6Q_A       125 YdvlkpYVAIFADSTRIMLEKWEKKacegksfdIFSDVGHMALDTLMKCTFGkgdsg-lnhrdSSYYVAVSELTLLMQQR 203 rabbit
NP_954686    147 YdvlkpYVKLISDSTKVMLDKWEVHsrseesfeLFKHVSLMTLDSIMKCAFScnsncqtdsgtNPYIQAVFDLCHLVNLR 226 Danio rerio
P15128       142 YdvlkpYVAIFADSTRIMLEKWEKKacegksfdIFSDVGHMALDTLMKCTFGkgdsg-lnhrdSSYYVAVSELTLLMQQR 220 rabbit
OCT84974     373 YdvlkpYVRLISDSTNVMLDKWVSFsnkgetveLFHHVSLMTLDSIMKCAFSfhsnc-qtdkdNSYTKAVYDLSFLAHHR 451 African clawed ...
NP_001316438 148 YdvlkpYVALMAESTNVMLDKWEKLitngksveLFEHVSLMTLDSIMKCAFSyhsnc-qtdrqNTYIQAVYDLCRMVHER 226 chicken
OCT84972     150 FdvlnlYVNQMAESTKIMLGKLEEQitssdtidIYPYVTLMTLDTIIKCTLGwnsnc-qidreNTYTNDLLELTRLLNER 228 African clawed ...
AGN04302     155 YdvlkhYVKLMSESTQVMLDKWESYantcetfeLFEHVSLMTLDSILKCAFShnrnrkreggtNKYIKAVYELSDLISFR 234 Indian medaka
AAI29578     149 YdvlkpYVTLMSNCTRVMLDKWDKLmpnektveLFHHVSLMTLDTIMKCAFSynssc-qnnrdNSYIKAVYELSYLLDQR 227 African clawed ...
Q64462       147 YdvlkpYVAIFAESTRVMLDKWEKKasenksfdIFCDVGHMALDTLMKCTFGkgdsg-lshsdNSYYLAVSDLTLLMQQR 225 house mouse
P15129       147 YdvlkpYVAIFAESTRMMLDKWEKKasenksfdIFCDVGHMALDTLMKCTFGkgdsg-lghrdNSYYLAVSDLTLLMQQR 225 Norway rat
Feature 1                                                                                        
5T6Q_A       204 IDSfqyhndfiywlTPHGRRFLRACRAAHDHTDRVIRQRKaalqdekerekiqnRRHLDFLDILLDVRGEsgvqlSDTDL 283 rabbit
NP_954686    227 FRVfpyhskaifhlSPHGYRFRKAASIAHNHTAEVIRKRKevlkmeeeqgivknRRYLDFLDILLSARDEhqqglSDEDI 306 Danio rerio
P15128       221 IDSfqyhndfiywlTPHGRRFLRACRAAHDHTDRVIRQRKaalqdekerekiqnRRHLDFLDILLDVRGEsgvqlSDTDL 300 rabbit
OCT84974     452 ARTfpyhnnliyylSPHGFLFRKACRIAHQHTGKVIKQRKtllqnkgefekvkqKRHPDFLDILLCARDEngnslSDEDL 531 African clawed ...
NP_001316438 227 LRIfpyhndfiywlSPHGYQFRKVCQLAHDHTDKVIQERKeslkderefekikkKRHLDFLDILLCAKDEtgaglSDEDL 306 chicken
OCT84972     229 LCFfpyysdfvfsfSPSGFLFRKVYKTSQQHTANIIKQRRetllredkldkdqqSRHLDFLEMLLASQDEngqglSDEDI 308 African clawed ...
AGN04302     235 MRTfpyhsdlifylSPHGFRLRRARRVAHSHTQEVIRKRKetlkee---tessrKKNLDFLDILLFAKNEnqqglSDEDI 311 Indian medaka
AAI29578     228 SRFflyhndvifylSPLGFRFRRALTVAHQHTDKVIKHRKqslmneteldkikqKRHLDFLDILLCAKDEngkglSDKDL 307 African clawed ...
Q64462       226 IDSfqyhndfiywlTPHGRRFLRACQIAHDHTDHVIRQRKaalqdekeqkklqeRRHLDFLDILLGARDEsgiklSDADL 305 house mouse
P15129       226 IDSfqyhndfiywlTPHGRRFLRACKIAHDHTDEVIRQRKaalqdekerkkiqqRRHLDFLDILLGVRDEsgiklSDAEL 305 Norway rat
Feature 1              #  ##  #                                                           ##  #  
5T6Q_A       284 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGdqdsfqweDLAKMTYLTMCMKECFRLYPPVPQVYR 363 rabbit
NP_954686    307 RAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDgkatleweDLNKIPYTTMCIKESLRLHPPVPGISR 386 Danio rerio
P15128       301 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGdqdsfqweDLAKMTYLTMCMKECFRLYPPVPQVYR 380 rabbit
OCT84974     532 RAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIREVLGekdsfeweHLSKIPYTTMCIKESLRLYPPVPGVSR 611 African clawed ...
NP_001316438 307 RAEVDTFMFEGHDTTASGLSWVLYCLASHPEHQARCREEIKDILGsrdtiqweDLGKMTYSTMCIKESLRLYPPVPGVSR 386 chicken
OCT84972     309 RAELDTIIFEGHNTTASGISWILYCMAKYPEHQHKCRKEIREVLRerdtlqwnDLTLFPYTTMCVKESLRLYSPMPILTR 388 African clawed ...
AGN04302     312 RAEVDPFMFEGHDTTASGVSFILFCLACHPEHQKKCRNEVMEALDgrdameweDLSKIPYTTMCIKESLRLYPPVPGISR 391 Indian medaka
AAI29578     308 RAEVDTFMFEGHDTTASGISWILYCMAKYPEHQHKCREEIRELLGdretmewgDLGQMPYTTLCIKESIRLYPPVPTIGR 387 African clawed ...
Q64462       306 RAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGdrdsfqwdDLAQMTYLTMCMKECFRLYPPVPQVYR 385 house mouse
P15129       306 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGdqdsfqwdDLAKMTYLTMCMKECFRLYPPVPQVYR 385 Norway rat
Feature 1                                                                   ###   #####  ##   #  
5T6Q_A       364 QLSKPVSFvdGRSLPAGSLISLHIYALHRNsdvWPDPEVFDPLRFSPenssgrhPYAFIPFSAGPRNCIGQQFAMNEMKV 443 rabbit
NP_954686    387 KLTKPLTFfdGRTVPEGCTIGVSIYGIHMNstvWENPYKFDPLRFLPenvanrsPHAFVPFSAGPRNCIGQNFAMNEMKV 466 Danio rerio
P15128       381 QLSKPVSFvdGRSLPAGSLISLHIYALHRNsdvWPDPEVFDPLRFSPenssgrhPYAFIPFSAGPRNCIGQQFAMNEMKV 460 rabbit
OCT84974     612 ELNKPITFydGRSLPAGSVIFINIFCIHRNpsvWKDPEVFDPLRFSSensskrhSHAFVPFAAGPRNCIGQNFAMNELKV 691 African clawed ...
NP_001316438 387 QLSKPITFhdGRTLPEGTITAISIYLIHRNplvWKDPLVFDPLRFSPenvsgrhSHAFLPFAAGMRNCIGQQFAMIEMKV 466 chicken
OCT84972     389 RLSKPISFsdGRSLPEGCLVSMCIDSIHRNpevWEDPEVFDPLRFSHensvllhSHAYLPFAAGPRNCIGQKFAMNEMTV 468 African clawed ...
AGN04302     392 ILTKPITFfdGRTLPAGFKVGTSVFGIHRNasvWENPEVFDPLRFLPenvskrsPHAFVPFSAGARNCIGQNFAMNEMKV 471 Indian medaka
AAI29578     388 RLSKPITFcdGRSLPEGTEVLTSIYAINRSpsvWNDPEVFDPLRFSPensdnrhSHAFVPFSAGARNCIGQNFAMNEMKV 467 African clawed ...
Q64462       386 QLSKPVTFvdGRSLPAGSLISLHIYALHRNsavWPDPEVFDPLRFSPenmtgrhPFAFMPFSAGPRNCIGQQFAMNEMKV 465 house mouse
P15129       386 QLNKPVTFvdGRSLPAGSLISLHIYALHRNstvWPDPEVFDPLRFSPenaagrhPFAFMPFSAGPRNCIGQQFAMNEMKV 465 Norway rat
Feature 1                                            
5T6Q_A       444 VTALCLLRFEfsVDPLRLPIKLpqLVLRSKNGIHLY 479 rabbit
NP_954686    467 AVALTLKRYYliKDPDHTPKMIpqVVLRSLNGIHIK 502 Danio rerio
P15128       461 VTALCLLRFEfsVDPLRLPIKLpqLVLRSKNGIHLY 496 rabbit
OCT84974     692 AVALTLNRYElsPDLSKPPLKSpqLVLRSKNGIHVY 727 African clawed frog
NP_001316438 467 ALALILLRFElsPDLTNPPHKIprLILRSKNGIHLY 502 chicken
OCT84972     469 AIALTLNAFElsLDPSQLPIKEalLVLKSKNGIHLR 504 African clawed frog
AGN04302     472 VIAMTLKKYQliEDPSLKPKIIprLVLRSLNGIHIK 507 Indian medaka
AAI29578     468 AVALTLQRYElfPDPDNEPQVIpqVVLRSLNGIHIK 503 African clawed frog
Q64462       466 VTALCLLRFEfsPDPSKIPIKVpqLILRSKNGIHLY 501 house mouse
P15129       466 VTALCLLRFEfsLDPSKMPIKVpqLILRSKNGIHLY 501 Norway rat

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