Conserved Protein Domain Family
CYP4V

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cd20680: CYP4V 
cytochrome P450 family 4, subfamily V
Cytochrome P450 family 4, subfamily V, polypeptide 2 (CYP4V2) is the most characterized member of the CYP4V subfamily. It is a selective omega-hydroxylase of saturated, medium-chain fatty acids, such as laurate, myristate and palmitate, with high catalytic efficiency toward myristate. Polymorphisms in the CYP4V2 gene cause Bietti's crystalline corneoretinal dystrophy (BCD), a recessive degenerative retinopathy that is characterized clinically by a progressive decline in central vision, night blindness, and constriction of the visual field. The CYP4V subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410773
Aligned: 12 rows
Threshold Bit Score: 861.374
Threshold Setting Gi: 632950934
Created: 20-Sep-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of Oryctolagus cuniculus CYP4B1 to heme, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                  #                ##      #   #      # 
Q6ZWL3        76 QIIEYTEEYRhMPLLKLWVgpVPMVALYNAENVEVILTSSKQIDKssmYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFH 155 human
Q9DBW0        76 QLIYYTEEFRhLPIIKLWIgpVPLVALYKAENVEVILTSSKQIDKsflYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFH 155 house mouse
A2RRT9        76 QIIQYTEEFRhLPIIKLWIgpVPLVALYKAENVEVILTSSKQIDKsfmYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFH 155 Norway rat
Q5RCN6        76 QIIEYTEEYRhMPLLKLWVgpVPMVALYNAENVEVILTSSRQIDKssmYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFH 155 Sumatran orangutan
NP_001001879  77 QLQQYADEFRkMPMFKLWLgpLPVTVLFHPDSVEVILSSSKHIKKsflYTFLHPWLGTGLLTSTGDKWRSRRKMITPTFH 156 chicken
NP_001073465  69 QIIEGTNENRhLPLAKVWVgpVPFLILYHAENIEVVLSNSRHLDKsysYRFLHPWLGTGLLTSTGEKWRNRRKMLTPTFH 148 zebrafish
XP_006006840  71 QMIEYTTVFRnEPLMKLWLgpVPFVVLFHAETVEVILSSSKHMDKsyaYKFLHPWLGTGLLTSTGEKWHSRRKMITPTFH 150 coelacanth
NP_001086053  70 QMCEFTELFRvEPLIKLWIgpIPFVIVYHADTVEPILSTSKHMDKsyaYKFLHPWLGQGLLTSTGEKWRSRRKMITPTFH 149 African clawed ...
XP_007891008  84 QLLESIDQFKdEPLMKVWLgpLPFIVLFHAECVEKILSSSKHLDKsyaYTFLQPWLGTGLLTSTGDKWRRRRKMLTPAFH 163 elephant shark
BAD02915      70 QMCEFAEDFRsEPLLKLWIgpIPFLIVYHADTLEPFLSTSKHVDKaylYKFLHPWLGKGLLTSTGEKWRIRRKMITPTFH 149 African clawed ...
AAI25941      69 QIIEGTNENRhLPLAKVWVgpVPFLILYHAENIEVVLSNSRHLDKsysYRFLHPWLGTGLLTSTGEKWRNRRKMLTPTFH 148 zebrafish
NP_001165651  70 QMCEFAEDFRsEPLLKLWIgpIPFLIVYHADTLEPFLSTSKHVDKaylYKFLHPWLGKGLLTSTGEKWRIRRKMITPTFH 149 Xenopus laevis
Feature 1                                                                                        
Q6ZWL3       156 FtiledFLDIMNEQANILVKKLEKHinqeaFNCFFYITLCALDIICETAMGKNIgaqsndDSEYVRAVYRMSEMIFRRIK 235 human
Q9DBW0       156 FtilenFLDVMNEQANILVNKLEKHvnqeaFNCFFYITLCALDIICETAMGKNIgaqsnnDSEYVRTVYRMSDMIYRRMK 235 house mouse
A2RRT9       156 FtiledFLDVMNEQANILVNKLEKHvnqeaFNCFFPITLCALDIICETAMGKNIgaqsngDSEYVRTVYRMSDMIYRRMK 235 Norway rat
Q5RCN6       156 FtiledFLDIMNEQANILVKKLEKHvnqeaFNCFFYITLCALDIICETAMGKNIgaqsndDSEYVRAVYRMSQMIFQRIK 235 Sumatran orangutan
NP_001001879 157 FailndFLEVMNEQGGVLLEKLEKHvdkepFNIFTDITLCALDIICETAMGKNLgaqdnkDSEYVRAVYRMSDLIQQRQK 236 chicken
NP_001073465 149 FsilsdFLEVMNEQTDILIQKMQKLedgepFNCFNFITLCALDIICETAMGKKIyaqsnaDSEYVQSVYKMSDIITKRQR 228 zebrafish
XP_006006840 151 FtilteFLEVMNEQSNILIEKLAKKvgqekFNCFTDITLCALDIICETAMAKKIyaqsnsDSEYVRAVYKMSDIVHRRQK 230 coelacanth
NP_001086053 150 FailseFLEVMNEQSKVCVEKLQKHvdgesFNCFMDVTLCALDIISETAMGRKIqaqnnrDSEYVQAIYKMSDIIQRRQK 229 African clawed ...
XP_007891008 164 FsilteFLEVMNEQTNILLEKLEAKagkgvFNCFNKITLCALDIICETAMGKKIhaqensESEYIQAIYRMSDLIQRRQK 243 elephant shark
BAD02915     150 FailseFLEVMNEQSNVLVEKLQKHadgesFDCFIDVTLCVLDIISETAMGRKIeaqsnkDSEYVQAIYKMADFIQNRQT 229 African clawed ...
AAI25941     149 FsilsdFLEVMNEQTDILIQKMQKLedgepFNCFNFITLCALDIICETAMGKKIyaqsnaDSEYVQSVYKMSDIITKRQR 228 zebrafish
NP_001165651 150 FailseFLEVMNEQSNVLVEKLQKHadgesFDCFIDVTLCVLDIISETAMGRKIeaqsnkDSEYVQAIYKMADFIQNRQT 229 Xenopus laevis
Feature 1                                                                                        
Q6ZWL3       236 mpwlwldlwylmFKEGWEHKKSLQILHTFTNSVIAERanemnanedc---rgdgrgsapsKNKRRAFLDLLLSVTDdegn 312 human
Q9DBW0       236 mpwlwfdlwylvFKEGRDHKRGLKCLHTFTNNVIAERvkerkaeedw---tgagrgpipsKNKRKAFLDLLLSVTDeegn 312 house mouse
A2RRT9       236 mpwfwfdlwylmFKEGRDHKKGLKSLHTFTNNVIAERvnarkaeqdc---igagrgplpsKTKRKAFLDLLLSVTDeegn 312 Norway rat
Q5RCN6       236 mpwlwldlwylmFKEGWEHEKGLKILHTFTNNVIAERanemnadedc---rgvgrgsapsKNKRRAFLDLLLSVTDdegn 312 Sumatran orangutan
NP_001001879 237 spwlwhdlmyllFKEGREHERNLKILHGFTDTVIAEKvaelentkltkhdtdvnteeesgSKKREAFLDMLLNATDdegk 316 chicken
NP_001073465 229 apwlwpdwiynkLKEGKEHAKRLKILHSFTANVIRERaefmssep--------dsdsdqgERKRQAFLDMLLKTTYengq 300 zebrafish
XP_006006840 231 mpwfwpdvfyytVGEGVEHDRNLKILHSFTESVIAERaqkmerleedt-cndssdsesrsTKKRKAFLDMLLNTTDeegn 309 coelacanth
NP_001086053 230 mpwlwldfiyahLKDGKEHNKNLKNLHAFTDKAILERaeelkkteakk-ghfdsepesekPKKRSAFLDMLLMATDdagn 308 African clawed ...
XP_007891008 244 mpwfwldfvyntFGEGKEHNHNLRILHSFTEKVIAERvremethvesnhsgfdldsnsksKKKRKAFLDLILSVTDengk 323 elephant shark
BAD02915     230 kpwlwsdslyayLKEGKEHNKTLNILHTFTDKAILERaeelkkmevk---kgdsdpesekPKKRSAFLDMLLMATDdagn 306 African clawed ...
AAI25941     229 apwlwpdwiynkLKEGKEHAKRLKILHSFTANVIRERaefmssep--------dsdsdqgERKRQAFLDMLLKTTYengq 300 zebrafish
NP_001165651 230 kpwlwsdslyayLKEGKEHNKTLNILHTFTDKAILERaeelkkmevk---kgdsdpesekPKKRSAFLDMLLMATDdagn 306 Xenopus laevis
Feature 1                     #  ##  #                                                           
Q6ZWL3       313 rlsHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGksdrpatveDLKKLRYLECVIKETLRLF 392 human
Q9DBW0       313 rlsQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGrshrpvtleDLKKLKYLDCVIKETLRVF 392 house mouse
A2RRT9       313 klsHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGrshrpvtleDLKKLKYLDCVIKETLRVF 392 Norway rat
Q5RCN6       313 rlsHEDIREEVDTFMFEGHDTTAAAINWSLYLLGCNPEVQQKVDHELDDVFGksdrpatveDLKKLRYLECVIKETLRLF 392 Sumatran orangutan
NP_001001879 317 klsYKDIREEVDTFMFEGHDTTAAAMNWVLYLLGHHPEAQKKVHQELDEVFGnterpvtvdDLKKLRYLECVVKEALRLF 396 chicken
NP_001073465 301 klsHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGsserhvgveDLKKLRYLECVIKESLRIF 380 zebrafish
XP_006006840 310 rlsLTDIREEVDTFMFEGHDTTAAAMNWVLHLVGSHQDVQRKIHDELDEVFGesdrpvlmeDLKKLRYLECVIKESLRLF 389 coelacanth
NP_001086053 309 klsYKDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKELDEVFGksdrpvtmdDLKKLRYLEAVIKEALRIY 388 African clawed ...
XP_007891008 324 klsHQDIREEVDTIMFEGHDTTAAALNWTLHLLGSHPNVLKKVHKELDDVFGnsdravtmeDLKNLHFLQCVIKESLRLF 403 elephant shark
BAD02915     307 kmsYKDIREEVDTFMFEGHDTTASALNWTLFLLGSHPEAQRQVHKELDEVFGksdrpvtmdDLKKLRYLEAVIKESLRIF 386 African clawed ...
AAI25941     301 klsHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGsserhvgveDLKKLRYLECVIKESLRIF 380 zebrafish
NP_001165651 307 kmsYKDIREEVDTFMFEGHDTTASALNWTLFLLGSHPEAQRQVHKELDEVFGksdrpvtmdDLKKLRYLEAVIKESLRIF 386 Xenopus laevis
Feature 1         #   #                                                            ###   #####  #
Q6ZWL3       393 PSvPLFARSVSEDCEVaGYRVLKGTEAVIIPYALHRDPrYFPNPEEFQPERFFPENaqGRHPYAYVPFSAGPRNCIGQKF 472 human
Q9DBW0       393 PSvPLFARSLSEDCEVgGYKVTKGTEAIIIPYALHRDPrYFPDPEEFRPERFFPENsqGRHPYAYVPFSAGPRNCIGQKF 472 house mouse
A2RRT9       393 PSvPLFARSLSEDCEVaGYKISKGTEAVIIPYALHRDPrYFPDPEEFQPERFFPENsqGRHPYAYVPFSAGPRNCIGQKF 472 Norway rat
Q5RCN6       393 PSvPLFARSVSEDCEVaGYRVLKGTEAVIIPYALHRDPrYFPNPEEFQPERFFPENaqGRHPYAYVPFSAGPRNCIGQKF 472 Sumatran orangutan
NP_001001879 397 PSvPMFARSLQEDCYIsGYKLPKGTNVLVLTYVLHRDPeIFPEPDEFRPERFFPENskGRHPYAYVPFSAGPRNCIGQRF 476 chicken
NP_001073465 381 PSvPLFARSICEACHInGFKVPKGVNAVIIPYALHRDPrYFPEPEEFQPERFMPENskGRHPYAYIPFSAGPRNCIGQRF 460 zebrafish
XP_006006840 390 PSvPFFARTLCEDCYIrGYRVPKGANAIIISYALHRDPdYFLDPEAFKPERFLPENltKRHPYAYIPFSAGLRNCIGQRF 469 coelacanth
NP_001086053 389 PSvPFFARTITEDCIIrGFHVPKGVNVVIIPYALHRDPeYFPEPEVFRPERFFSENasGRNPYAYIPFSAGLRNCIGQRF 468 African clawed ...
XP_007891008 404 PSvPFFARTLCEDCYIrGFKVPKGVNAIIVPYVLHRDPtYFPEPEEFKPERFLLENssKLNPYAFIPFSAGIRNCIGQRF 483 elephant shark
BAD02915     387 PPvPMFGRTVTEDCTVrGFKVPKGVNIIVITYSLHRDPeYFPEPEEFRPERFFPENasGRNPYAYIPFSAGLRNCIGQRF 466 African clawed ...
AAI25941     381 PSvPLFARSICEACHInGFKVPKGVNAVIIPYALHRDPrYFPEPEEFQPERFMPENskGRHPYAYIPFSAGPRNCIGQRF 460 zebrafish
NP_001165651 387 PPvPMFGRTVTEDCTVrGFKVPKGVNIIVITYSLHRDPeYFPEPEEFRPERFFPENasGRNPYAYIPFSAGLRNCIGQRF 466 Xenopus laevis
Feature 1        #   #                                      
Q6ZWL3       473 AVMEEKTILSCILRHFWiesnQKREELGLEGQLILRPSNGIWI 515 human
Q9DBW0       473 AVMEEKTILACILRQFWvesnQKREELGLAGDLILRPNNGIWI 515 house mouse
A2RRT9       473 AVMEEKTILACILREFWiesnQKREELGLAGDLILRPNNGIWI 515 Norway rat
Q5RCN6       473 AVMEEKTILSCILRHFWiesnQKREELGLEGQLILRPSNGIWI 515 Sumatran orangutan
NP_001001879 477 AQMEEKTLLALILRRFWvdcsQKPEELGLSGELILRPNNGIWV 519 chicken
NP_001073465 461 AMMEEKVVLATILRHFDveacQSREELRPLGELILRPEKGIWI 503 zebrafish
XP_006006840 470 ALMEEKVVLSAILRHFWvetkQRREDLRPVGELILRPQDGIWI 512 coelacanth
NP_001086053 469 ALMEEKVVLSSILRNYWveatQKREELCLLGELILRPQDGMWI 511 African clawed frog
XP_007891008 484 AIMEEKVILSTILRRFHveakQCREDLVLMGELILRPQNGIWI 526 elephant shark
BAD02915     467 ALMEEKVVLSSILRKYWveatQKRDECLLVGELILRPQDGMWI 509 African clawed frog
AAI25941     461 AMMEEKVVLATILRHFDveacQSREELRPLGELILRPEKGIWI 503 zebrafish
NP_001165651 467 ALMEEKVVLSSILRKYWveatQKRDECLLVGELILRPQDGMWI 509 Xenopus laevis

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