5W0T


Conserved Protein Domain Family
RecA-like_ATAD1

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cd19520: RecA-like_ATAD1 
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
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PSSM-Id: 410928
Aligned: 9 rows
Threshold Bit Score: 298.569
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATP
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ####                                       #######                             
5W0T_A         43 DIGGLDPLISDLHESVIYPLXXPEvysnsp-llqapSGVLLYGPPGCGKTXLAKALAkesgaNFISIRXSSIXDKWYGES 121  Saccharomyces...
Q9P7J5         90 DIGGMDEHVNQLLQDVLFPLKYPEvfdthggllscpKGLLLYGPPGCGKTMLAKALAkqsqaTFINVSVGLLTDKWFGES 169  fission yeast
B4F6J6         92 DIAGLDDVITDLKDTVILPIRKRYlfensr-llqppKGVLLYGPPGCGKTMIAKATAkeagcRFINLQPSTLTDKWYGES 170  western clawe...
F6QV99         92 DIAGLDDVITDLKDTVILPIKKKHlfensr-llqppKGVLLYGPPGCGKTLIAKATAkeagcRFINLQPSTLTDKWYGES 170  Odocoileus vi...
Q503W7         96 DIAGLDEVITELKDTVILPIQKRHlfegsr-llqppKGVLLYGPPGCGKTLIAKATAkeagfRFINLQPSTLTDKWYGES 174  zebrafish
NP_501861      81 EIGGCEELVAELKDRIILPLRFASqsgsh--llsppRGILLYGPPGCGKTLLAKAVAraagcRFINLQVSNLTDKWYGES 158  Caenorhabditi...
NP_001285800   18 DIAGLDSVIQELRESVVLPIQHKDlfkhsk-lwqapKGVLLHGPPGCGKTLIAKATAkeagmRFINLDVAILTDKWYGES 96   fruit fly
NP_567238     964 DIGALENVKETLKELVMLPLQRPElfdkgq-ltkptKGILLFGPPGTGKTMLAKAVAteagaNFINISMSSITSKWFGEG 1042 thale cress
NP_194498      85 SIGGLETIKQALYELVILPLKRPElfaygk-llgpqKGVLLYGPPGTGKTMLAKAIAkesgaVFINVRVSNLMSKWFGDA 163  thale cress
Feature 1                                                                                         
5W0T_A        122 NKIVDAXFSLANKlqPCIIFIDEIDsflre-rsstDHEVTATLKAEFXTLWDGLLnng--rvXIIGATNRIndIDDAFLR 198  Saccharomyces...
Q9P7J5        170 NKLVDALFTLARKlePTIIFIDEIDtflrq-rqrtDHEAMAQIKAEFMSMWDGLLsgq-srvLVLGATNRPadIDEAIRR 247  fission yeast
B4F6J6        171 QKLAAAVFSLAVKlqPSIIFIDEIDsflrs-rsssDHEATAMMKAQFMSLWDGLDtdfncqvIVMGATNRPqdLDTAIMR 249  western clawe...
F6QV99        171 QKLAAAVFSLAIKlqPSIIFIDEIDsflrn-rsssDHEATAMMKAQFMSLWDGLDtdhscqvIVMGATNRPqdLDSAIMR 249  Odocoileus vi...
Q503W7        175 QKLAAAVFSLAIKlqPSIIFIDEIDsflrn-rsssDHEATAMMKAQFMSLWDGLDtdyncqvIIMGATNRPqdLDSAILR 253  zebrafish
NP_501861     159 QKLAAAVFSVAQKfqPTIIFIDEIDsflrd-rqshDHESTAMMKAQFMTLWDGFSssg-dqiIVMGATNRPrdVDAAILR 236  Caenorhabditi...
NP_001285800   97 QKLTSAVFSLASRiePCIIFIDEIDsflrs-rnmnDHEATAMMKTQFMMLWDGLStnanstvIVMGATNRPqdLDKAIVR 175  fruit fly
NP_567238    1043 EKYVKAVFSLASKiaPSVIFVDEVDsmlgrrenpgEHEAMRKMKNEFMVNWDGLRtkdrervLVLAATNRPfdLDEAVIR 1122 thale cress
NP_194498     164 QKLVSAVFSLAYKlqPAIIFIDEVEsflgq-rrstDHEAMANMKTEFMALWDGFStdpharvMVLAATNRPseLDEAILR 242  thale cress
Feature 1                 
5W0T_A        199 RLPKRFLV 206  Saccharomyces cerevisiae S288c
Q9P7J5        248 RMPKVFSI 255  fission yeast
B4F6J6        250 RMPTRFHI 257  western clawed frog
F6QV99        250 RMPTRFHI 257  Odocoileus virginianus texanus
Q503W7        254 RMPTRFHI 261  zebrafish
NP_501861     237 RMTARFQV 244  Caenorhabditis elegans
NP_001285800  176 RMPAQFHI 183  fruit fly
NP_567238    1123 RLPRRLMV 1130 thale cress
NP_194498     243 RLPQAFEI 250  thale cress

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