6BOA,5HI9,5IRX,6O20


Conserved Protein Domain Family
TRPV

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cd21882: TRPV 
Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Statistics
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PSSM-Id: 411975
Aligned: 4 rows
Threshold Bit Score: 921.585
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 68 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:All members of the TRPV channel subfamily have a basic architecture of homo- or hetero-tetrameric arrangements around a central pore. Different subunits within the TRP family are also able to form heteromeric channels, with the heteromeric channels exhibiting distinct functional properties as compared to the homomeric channels.
  • Structure:6BOA: Human TRPV6 forms a homotetramer; contacts at 4A.
    View structure with Cn3D
  • Structure:5H19: Rat TRPV2 forms a homotetramer; contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          ##                                         
6BOA_A     61 LNKLLKYedc----------kvHQRGAMGetalHIAALYDn---LEAAMVLMeaap------elvfEPMTSELYEGQTAL 121 human
5HI9_A     89 PEELTGLleylrwnskyltdsaYTEGSTGktclMKAVLNLqdgvNACIMPLLqidkdsgnpkplvnAQCTDEFYQGHSAL 168 Rattus norvegicus
5IRX_A     24 LESLLPFlqrskk---rltdseFKDPETGktclLKAMLNLhngqNDTIALLLdvarktdslkqfvnASYTDSYYKGQTAL 100 Rattus norvegicus
6O20_A     61 LKILLLNqsc----------dfQQRGAVGetalHVAALYDn---LEAATLLMeaap------elakEPALCEPFVGQTAL 121 rabbit
Feature 1         ##                                ##                                        
6BOA_A    122 HIAVVNqnmNLVRALLARrasvsaRATGTAFrrs-pcnLIYFGEHPLSFAACVNsEEIVRLLIEHGadira---qdslGN 197 human
5HI9_A    169 HIAIEKrslQCVKLLVENgadvhlRACGRFFqkh-qgtCFYFGELPLSLAACTKqWDVVTYLLENPhqpasleatdslGN 247 Rattus norvegicus
5IRX_A    101 HIAIERrnmTLVTLLVENgadvqaAANGDFFkktkgrpGFYFGELPLSLAACTNqLAIVKFLLQNSwqpadisardsvGN 180 Rattus norvegicus
6O20_A    122 HIAVMNqnlNLVRALLARgasvsaRATGAAFrrs-phnLIYYGEHPLSFAACVGsEEIVRLLIEHGadira---qdslGN 197 rabbit
Feature 1                                                                                     
6BOA_A    198 TVLHILILQPnkt-----faCQMYNLLLSYDrhgdhlqplDLVPNHQGLTPFKLAGVEgNTVMFQHLMQK---------- 262 human
5HI9_A    248 TVLHALVMIAdnspensalvIHMYDGLLQMGarlcptvqlEEISNHQGLTPLKLAAKEgKIEIFRHILQRefsgp-yqpl 326 Rattus norvegicus
5IRX_A    181 TVLHALVEVAdntvdntkfvTSMYNEILILGaklhptlklEEITNRKGLTPLALAASSgKIGVLAYILQReihepecrhl 260 Rattus norvegicus
6O20_A    198 TVLHILILQPnkt-----faCQMYNLLLSYDehsdhlqslELVPNHQGLTPFKLAGVEgNTVMFQHLMQK---------- 262 rabbit
Feature 1          #######                                                   #                
6BOA_A    263 -RKHTQWTYGPLTSTLYDLTeIDSSGDEQsLLELIITTKkrear--qildqTPVKELVSLKWKRygRPYFCMLGAIYLLY 339 human
5HI9_A    327 sRKFTEWCYGPVRVSLYDLSsVDSWEKNS-VLEIIAFHCkspnrh-rmvvlEPLNKLLQEKWDRl-VSRFFFNFACYLVY 403 Rattus norvegicus
5IRX_A    261 sRKFTEWAYGPVHSSLYDLScIDTCEKNS-VLEVIAYSSsetpnrhdmllvEPLNRLLQDKWDRfvKRIFYFNFFVYCLY 339 Rattus norvegicus
6O20_A    263 -RKHVQWTCGPLTSTLYDLTeIDSWGEELsFLELVVSSKkrear--qileqTPVKELVSFKWKKygRPYFCVLASLYILY 339 rabbit
Feature 1         #  ## #                                                                     
6BOA_A    340 IICFTMCCIYRplkprtnnrtsprdntllqqkllqeaymtpkDDIRLVGELVTVIGAIIILLVEVPDIFRMgvtrffgqt 419 human
5HI9_A    404 MFIFTVVAYHQpsldqpai---------------psskatfgESMLLLGHILILLGGIYLLLGQLWYFWRRrlfiwis-- 466 Rattus norvegicus
5IRX_A    340 MIIFTAAAYYRpveglppy----------------klkntvgDYFRVTGEILSVSGGVYFFFRGIQYFLQRrpslksl-- 401 Rattus norvegicus
6O20_A    340 MICFTTCCIYRplklrddnrtdprditilqqkllqeayvthqDNIRLVGELVTVTGAVIILLLEIPDIFRVgasryfgqt 419 rabbit
Feature 1                                        ## ##  ## ##           #  ##  #      #  ##  #
6BOA_A    420 ilggpfHVLIITYAFMVLVTMVMRLIsasgevvpmSFALVLGWCNVMyfaegfqmlgpFTIMIQKMIFgdlmRFCWLMAV 499 human
5HI9_A    467 fmdsyfEILFLLQALLTVLSQVLRFMetewylpllVLSLVLGWLNLLyytrgfqhtgiYSVMIQKVILrdllRFLLVYLV 546 Rattus norvegicus
5IRX_A    402 fvdsysEILFFVQSLFMLVSVVLYFSqrkeyvasmVFSLAMGWTNMLyytrgfqqmgiYAVMIEKMILrdlcRFMFVYLV 481 Rattus norvegicus
6O20_A    420 ilggpfHVIIITYASLVLLTMVMRLTnmngevvplSFALVLGWCSVMyfargfqmlgpFTIMIQKMIFgdlmRFCWLMAV 499 rabbit
Feature 1       ### ## ### ####                                  ## ##                  ###  #
6BOA_A    500 VILGFASAFYIIFQTEDpeelgh--------------------fydypmALFSTFELfltiidgpanynvdlpfMYSITY 559 human
5HI9_A    547 FLFGFAVALVSLSREARspkapednnstvteqptvgqeeepapyrsildASLELFKFtigmgelafqeqlrfrgVVLLLL 626 Rattus norvegicus
5IRX_A    482 FLFGFSTAVVTLIEDGKyns--------------------------lysTCLELFKFtigmgdleftenydfkaVFIILL 535 Rattus norvegicus
6O20_A    500 VILGFASAFHITFQTEDpnnlge--------------------fsdyptALFSTFELfltiidgpanysvdlpfMYCITY 559 rabbit
Feature 1     #  #     # ##### ##                                                            #
6BOA_A    560 AAFAIIatlLMLNLLIAMMgdthwrvaherDELWRAQIVATTVMLERklprclwprsg-------icgreyglgdRWFLR 632 human
5HI9_A    627 LAYVLLtyvLLLNMLIALMsetvnhvadnsWSIWKLQKAISVLEMENgywwcrrkkhregrllkvgtrgdgtpdeRWCFR 706 Rattus norvegicus
5IRX_A    536 LAYVILtyiLLLNMLIALMgetvnkiaqesKNIWKLQRAITILDTEKsflkcmrkafrsgkllqvgftpdgkddyRWCFR 615 Rattus norvegicus
6O20_A    560 AAFAIIatlLMLNLFIAMMgdthwrvaqerDELWRAQVVATTVMLERkmprflwprsg-------icgyeyglgdRWFLR 632 rabbit
Feature 1      ###
6BOA_A    633 VEDR 636 human
5HI9_A    707 VEEV 710 Rattus norvegicus
5IRX_A    616 VDEV 619 Rattus norvegicus
6O20_A    633 VENH 636 rabbit

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