Conserved Protein Domain Family

cl02689: RUN Superfamily 
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RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Accession: cl02689
PSSM Id: 413440
Name: RUN
Created: 8-Feb-2008
Updated: 24-Nov-2020
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