Conserved Protein Domain Family
SH3

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cl17036: SH3 Superfamily 
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Src Homology 3 domain superfamily
Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.
Links
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Taxonomy: root
PubMed: 2342 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl17036
PSSM Id: 418401
Name: SH3
Created: 31-Jul-2012
Updated: 24-Nov-2020
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