Conserved Protein Domain Family
Frizzled
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pfam01534: Frizzled (this model, PSSM-Id:426311 is obsolete and has been replaced by 460242)
Frizzled/Smoothened family membrane region
This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.
Links
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Statistics
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PSSM-Id: 426311
Aligned: 86 rows
Threshold Bit Score: 206.279
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDS39317     196 QSKRiKFSRLWIGLWSGLCAASTLFTILTFFIDINRFQYPErpiiflsmcyfmvavtyitglslgnkiscsgpfppasfd 275 Echinococcus mu...
XP_011422642 233 EQER-HFAKLWIGVWSSICLASTLFTVLTFFVDMTRFRYPErpiiflsgcyfmvalayvigfsld--------------- 296 Pacific oyster
EFX86266     244 ESEV-RFSRVWIVVWGAICMASCLFTVLTFLLDVRRFRYPErpvvflsvcyfmvalayvigyamgdsv---------scn 313 common water flea
XP_002433979 232 GENL-KFSRYWIGAWAVQCMVSTLFTVLTFLIDMQRFRYPErpiiflsfcnlmvsatyfagfvlgdq-----------va 299 black-legged tick
OWR44925       5 EDEK-NFARLWIGTWATLCTVSCLFTVLTFLIDTDRFRYPErpiiflsvcylmvaaayvmgwssgdt-----------vs 72  Danaus plexippu...
XP_006568530 230 ERER-RFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPErpiiflsvcylmvalayvigwaagns------------i 296 honey bee
NP_001164247 218 ENKQ-KFSRVWIGTWAVLCSASCLFTVCTFLIDTNRFRYPErpiiflsvcylmvalayvvgfiagd-------------- 282 red flour beetle
EEN61413     225 DDEV-EFAQVWIGIWSVLCACSCLFTVLTYLIDPGRFRYPErpiiflsacylmvsvayivgya----------------- 286 Florida lancelet
XP_023269769 218 DKEI-HFSRIWILVWSVLCCASTLFTVTTYLVDMQRFRYPErpiiflsgcytmvsiayiagyfl---------------- 280 Seriola lalandi...
1_pfamImport   4 PEEL-RFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPErpiiflsgcytavavayiagfll---------------- 66 

CDS39317     276 saasltskplsisssypilitqgtKFEGCTILFMMLYFFSMAGHIWWVVLTVTWYLAARCHWAHEAIFRNAQYLHFAAWA 355 Echinococcus mu...
XP_011422642 297 -keaaacnrfvntpevvpittqgtKKEWCTILFMMMYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWA 375 Pacific oyster
EFX86266     314 apfdppqdfsvdkadmvetitqgtKRESCTILFMLLYYFEMAANLWWVVLTLTWFLAAGLKWGHEPIEAKSHYFHLVTWA 393 common water flea
XP_002433979 300 cnepfdppgghanmemvrtitqnnKKETCTVMFMVLYFFSMAGSIWWVVLTLTWFLAAGLKWGHEAIESNSQYFHLAAWT 379 black-legged tick
OWR44925      73 cqgpfpltvsgtrlpntsvitqgtKHEPCTILFMVVYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWA 152 Danaus plexippu...
XP_006568530 297 acrepfpppldmriqmastitqgtKHELCTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWA 376 honey bee
NP_001164247 283 siackeppisdegirkvsiitqgtKYELCTILFMVLYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWA 362 red flour beetle
EEN61413     287 --lkekvscmeehhrnfrrilhgtKKEGCTILFMMLYFFSMASSLWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWA 364 Florida lancelet
XP_023269769 281 --gdkvvcndsfspdgyktivqgtKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWA 358 Seriola lalandi...
1_pfamImport  67 --eervvcnerfaedgsrtvaqgtKREGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQ-------- 136

CDS39317     356 IPAAMTICLLAMGKVDGDPLSGVCFTGLTDPTIVRYFLIAPLCISLLLGACFLIAGFVSLFKIRTIIKTGGSKTNDLEKL 435 Echinococcus mu...
XP_011422642 376 VPAIKTIAILAMGQVDGDTLSGICFTGIFDVDALRGFVLAPLVVYLLLGTSFLLAGFVSLFKIRTIMKSDGTKTDKLEKL 455 Pacific oyster
EFX86266     394 LPAALTIAILAMGKVEGDVLSGVCSVGIWDMSALRLFVLAPLFLFLIVGTIFLLGGFISLFRVRTLMKSGGTKTDKLEKF 473 common water flea
XP_002433979 380 IPAVKTITILAMGKVEGDVLSGVCYVGLWNMDALRGFVLAPLFVYLALGKVFLMAGFISLCHIRTVMKHDGTKTDKLEKL 459 black-legged tick
OWR44925     153 VPAIKTISILAMGKVDGDVLSGVCYVGLWDSEALRGFVLAPLCVYLVLGTIFLFAGFVSLFRIRTVMKHDGTKTDKLEKL 232 Danaus plexippu...
XP_006568530 377 APAIKTVTILAMGKVEGDILSGVCYVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFVSLFRIRTVMKHDGTKTDKLEKL 456 honey bee
NP_001164247 363 IPAVKTITILAMGKVDGDVLSGVCYVGIWNVDALRIFILIPLCIYLVFGLVFLTSGLISLFRIRTVMKHDGTKTDKLEKL 442 red flour beetle
EEN61413     365 VPAVKTIAILAMGKVDGDVLSGVCFVGISDIDALRGFVLAPLFLYLVIGTLFLLAGFVSLFRIRTIIKQDGTKTDKLEKL 444 Florida lancelet
XP_023269769 359 VPAVKTISILAIGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERL 438 Seriola lalandi...
1_pfamImport 137 --------------VDGDVLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKL 202

CDS39317     436 IFRIGVFSLLYLLPAAVVIACYIYESQKMDRWMLTWytneVCrnfdlrkiagssKCiaqlhqilgdtepasstsggdVFD 515 Echinococcus mu...
XP_011422642 456 MVRIGIFSVLYTVPATIVIACYFYEQASRDTWMLHWft-kEClass-----tapPeegi---------------kllQSG 514 Pacific oyster
EFX86266     474 MLRIGIYSFLYTVPAIIVIACLLHEQAFFDSWMLRWqe-dKCrdpqw--ikfvfACpsqslaya------kgaggypTAP 544 common water flea
XP_002433979 460 MVRIGIFSFLYTLPALTVLCCYFYEQAHFDDWMLGWhwqvna------ekrwsiPCpeps--------------clrRDR 519 black-legged tick
OWR44925     233 MIRIGIFGVLYTVPALIVIACLFYEQVHFDSWMLTWhr-dMCskpv-----ysiPCp-------------------fTPH 287 Danaus plexippu...
XP_006568530 457 MIRIGIFSVLYIVPALIVIACLFYEQAYFDQWMLTWnm-eMCsrpgpq-slysmPCpvg----------------erTRD 518 honey bee
NP_001164247 443 MIRIGVFSILYTVPAMMVIACLFYEQFNFDNWMLTWnh-dMCvkqt-----yavPCp-------------------qDIR 497 red flour beetle
EEN61413     445 MIRIGVFSVLYTVPATIVIACYFYEQAFRREWERSWei-dNCkdy-------fiPCpp-----------------gpHAR 499 Florida lancelet
XP_023269769 439 MVRIGVFSVLYTVPATIVIACFFYEQAFRPHWERSWvn-hNCrgl-------aiPCp-------------------lQTG 491 Seriola lalandi...
1_pfamImport 203 MVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSWvt-qSCksy-------aiPCpnn----------------hsSHH 258

CDS39317     516 KMDTPTFELFMIKYLMTLIVGITSGIWVWSSKTLHSWHVffaRI 559 Echinococcus multilocularis
XP_011422642 515 DKPWPDFNVFMIKYLMTVIVGITSGVWIWTGKTLSSWKRfyaKI 558 Pacific oyster
EFX86266     545 TYPKPEFAVFMIKYLMMLIVGISSGFWVMSSKTLATWSNfyrRL 588 common water flea
XP_002433979 520 ALRRPEFYVFMIKYLGILIVGITSGVWIWSGKTFASWRNfyaRL 563 black-legged tick
OWR44925     288 EVDRPKFEMFMIKYLMTMIVGITSSFWIWSGKTLVSWRQffdKI 331 Danaus plexippus plexippus
XP_006568530 519 VGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQffnHI 562 honey bee
NP_001164247 498 EYSHPLFPIFMIKYLMYMIVGITSSVWIWSGKTVHSWKVflnRL 541 red flour beetle
EEN61413     500 PSANPDFTVFMIKYLMALIVGITSGIWIWTGKTVQAWKRfygQI 543 Florida lancelet
XP_023269769 492 PRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKfytRL 535 Seriola lalandi dorsalis
1_pfamImport 259 PPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKfytRL 302
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