Conserved Protein Domain Family
Elongin_A

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pfam06881: Elongin_A 
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Statistics
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PSSM-Id: 429170
Aligned: 101 rows
Threshold Bit Score: 76.8712
Threshold Setting Gi: 328871862
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG12725      20 LKDVGNCVYELIRPVLFACPPDQLAEIEDLSPHLM--LESDEIWLLHLRRDFPNESKPQATRtiepepnsepyptqtinp 97  Melampsora lari...
EFJ31392      23 FGDVGDTDLDLLRIILPHCTTDQLRHIENCSKDRDlaPVTNELWKKCYGRDFGPHSLELVESklkha------------- 89  Selaginella moe...
XP_006827203  22 LGDVGETDLNILKLILTHCTADQLMHIEKCSEGRDlsPVTDSLWKTFYEQHFGTESANIVIKrmkqk------------- 88  Amborella trich...
XP_006348930  23 LGDVGETDTHLLERILPHCSLEQLTHVENSTEGRDlsQVTDRLWKRFYQIEFGDKSINQVVErmkkv------------- 89  potato
XP_019079367  47 LGDVGETDINLLDHILPHCTVDQLMHIEKCTEERDlsEVTDKLWKKFYEKEFGVKSTNLVVErmklk------------- 113 wine grape
KRH46092      32 LGNVGSLDQHLLEQILPHCTADQLMHVEKSTKGRNlsPVTDKLWKKFYEKQFGTNNTNEVIKrmkek------------- 98  soybean
EEF36498      34 LGDVGETDLHLLDQILPHCTMDQLMHVEKSTQGRDlsPITDKLWKTFYEKQFGEREANVAIErmrry------------- 100 castor bean
XP_018686693  25 IGDVGEVDLYLLKDILPHCNIDQLTHIEDSTQGRDlsPVTDALWKRFYEQQFGVESANTVIKrmkqk------------- 91  wild Malaysian ...
XP_010234349  25 VSSMDGVEMQLLKRILPHCTLDQLTRIESCTE-MDisPATDVLWKTFYQRQFGEDHTNNVVKkmkqs------------- 90  stiff brome
XP_009133550  28 IGYVGGVDFQLLEKILQHCTLEQLMHIEDSTPDTDlsPVTNELWKRFYEKQYGAKNLSFVMEkmers------------- 94  field mustard
EGG12725      98 ytnepidlpIHRIQYFTIKQSKAKALANASARLRERTQANRSEFSKRKA 146 Melampsora larici-populina 98AG31
EFJ31392      90 ----sksqfKWRDLYEAKLKHREEKQQKGVELLQRLHMEEESKKQSRQL 134 Selaginella moellendorffii
XP_006827203  89 -----gryfKWKLLYQAKLKERDEAQKKSVDRMKQLYAEESNRKQSRQI 132 Amborella trichopoda
XP_006348930  90 -----kvtfKWKQLYEAKTEEMEETQQRSFERIKELYQNENAKRQSRQV 133 potato
XP_019079367 114 -----kvsfKWSKLYEAKLKDRDEAQKKSFDRIKQLYQKEDARKQSRQV 157 wine grape
KRH46092      99 -----rvnfRWMQLYEAKGKERAQAENEALDRIRQLYKKEDARKQSRQV 142 soybean
EEF36498     101 -----kvsfRWKKLYQAKLNEIAKKEDEAVARLRQSYKKEDDKKQSRQI 144 castor bean
XP_018686693  92 -----kivfKWRQLFEAKTKEREEAQNKMGEKLKQRYAETQAKKQSRQI 135 wild Malaysian banana
XP_010234349  91 -----gvnyQWKDLFNAKTEKQKELEEIMIQRLAKKYQAEKAEKQSKQI 134 stiff brome
XP_009133550  95 -----kvsfKWRELYEAKLKVVEEDEKEAVDRLKQRYKNEDARKQSRQT 138 field mustard
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