Conserved Protein Domain Family
Microcephalin

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pfam12258: Microcephalin (this model, PSSM-Id:432433 is obsolete and has been replaced by 463511)
Microcephalin protein
This family of proteins is found in eukaryotes. Proteins in this family are typically between 384 and 835 amino acids in length. Microcephalin is involved in determining the size of the brain in animals. It is a protein, which if expressed homozygously causes the organism to have the condition microcephaly. Organisms expressing the mutated form of this protein in a homozygous manner develop a condition called microcephaly - a drastically reduced brain mass and volume. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.
Statistics
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PSSM-Id: 432433
Aligned: 20 rows
Threshold Bit Score: 353.643
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023486251 256 ESFAGGLHSSFEDLCGNSGCGNQERKVGGFVDEIKSDRCVSSPVLKTSSIHVSASPGYVSQLTPQKFMSNLSKEEIHWQR 335 horse
2_pfamImport   1 DSFAGGLPVSAEDLCGGSASGTQERNLGEFITERGSGVRAASPVLQTGQLSPSAAPHPLGLLTPRRSTSSPPKAETPQQS 80 
NP_001096785 231 NSLAGGLPVSADDLCGGSASGTQEGKLFEFITERGSDVCAASPVLQTGSVGPSAAPCPLDLLTPHRSTSSPPKAETPQQS 310 cattle
XP_025301431 231 ESFADDLNSSFDNLCGKTGCGSQEEKLAGFVDQVKSDVCVSSPALKTSCVPSLAPPGYLCQLTPQKPTGALSKEEIRGQR 310 dingo
XP_004766810 231 ESFAGDLNSSFDDVCGKVRCGSQEAALGGIVDEI-----VSSPALKTRSIHSAASPGCLPPLTPQKPMGSPSKEEIRGLG 305 domestic ferret
5_pfamImport   1 VSFAGDLHSSFDDLCGNVRCGSQEGKLGGIVDEIKSDVCVSSPVLKTR------SPGYLSPLTPQKPMDSLSKEETGRWG 74 
4_pfamImport   1 ESFASGSHSSFGDS-----CGDQERKLGRSANEMTTVTCPSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQK 75 
XP_005334413 222 DFFAGGSRSPLDAFRGESRCRNQGSQSGRTTKETRSDTCTSSCVLEIDSTCSPALSGRLCPSSPQRSESPLSEEERSWQK 301 thirteen-lined ...
XP_007671505  73 DPVVDDSNSSSDDLRGSLKSERRKKSVSGS-REVESGARVTTSDLNPREKPSAASSTDPSRVTPKRTKEQIAKEKQGSQH 151 platypus
XP_007476295 233 EFISDVLNTSFDDIWRNSEQRKRTVKSEKHTREANTDTCLSSPISKT------ASCHLFDSITPQRSKSNLTAENRNFQN 306 gray short-tail...
XP_023486251 336 DPVGEIVAPDTKHSEGITKEAFDKKCSLSPTLSATKGHSLGQSR---PKSSSAKRRMTSENLPSS-------PKEKLKRK 405 horse
2_pfamImport  81 GAAGGVVTPVSKPSRPAAQGPSDGKRRLSPVSSATKGRPGGRAQ---RMGSSTKRKKTPENSCPA-------SEKRQKRR 150
NP_001096785 311 RAARGVVTPISKPSKPVAQGSSDGKKRLSPVSSATKGRPGGREQ---HMGSSAKRKKTPENSCPG-------LEERRKRR 380 cattle
XP_025301431 311 DPAAEVVTPDKQQSEGAAREGLDEKHNLSPVPSASKCRPSGHSR---SKSSPAKRKRVSGSSNSH-------PEERLQKK 380 dingo
XP_004766810 306 DPAGEVVTPAKQQSEGAAGMVFDEKCSLSPMLSATKCRPSGQSR---SESSSAKRKRRSESLGAP-------PEERL-KK 374 domestic ferret
5_pfamImport  75 DAVGVVVTLDKQQSEGATRIMSNEKHSLSPLLSATKRCPSGHSR---SESSSARRRRTSERVNAP-------PKEGLQKK 144
4_pfamImport  76 DATGAVADSERKQAAGVSQGVPDEKLCLSPTMSIIEEHQVRLG----PKNSSAKRKRAA-DLGSS-------PKGKL-KK 142
XP_005334413 302 DAVGEAVAPDGRPAQGVS-----GDRSTAPAST-----VLVHSR---PWSASPRRERASVGLGSP-------PEEQVKKR 361 thirteen-lined ...
XP_007671505 152 TLVTELHNVERGRSEGMSERTLVDRDPLGPSAATPKSHPFRQAKgpiPENLTNKMNHCWPRINSPttsdelgAKEKSRGK 231 platypus
XP_007476295 307 TLTTEVLTPEKTHFEEVSKKLFSDKDYLNP-LAIVESHSTKSPR---PTNTSEKQLRSLMHINSP-------LKEKSRKK 375 gray short-tail...
XP_023486251 406 RYNGKSTMPKLqlfKSESSLQFRTRSATTTPDCGESSYDDYFSPDNLKERN---SENLLpG-CQSSSRPAQFYCRRNLSK 481 horse
2_pfamImport 151 RSLGQRPAPRL---RAESGLRSVQRAAVKNLALEEFSYDDYFSPDNLKERV---SEGLL-G-EQLPSRPPPLHCQRSLSK 222
NP_001096785 381 RSLGQRPAPRLrlwKAERGLRSVRRPAVKSLALEEFSYDDYFSPDNLKERV---SEGLL-G-EQLPSRPPALHCQRSLSK 455 cattle
XP_025301431 381 KCSGKAAGPQVqlwKSGGRLPFTAWPAVEAPGGEVSSYDDYFSPDNLRERS---SEALLpG-PQPSAGPAQFSC-RGLSQ 455 dingo
XP_004766810 375 RCGGQPGRPRVrlwTSGHPLPLPAGPAGETAGCGMSSYDDYFSPDNLRERS---SEPLLpG-CQPSAGLAQLSRSGGLSQ 450 domestic ferret
5_pfamImport 145 RCGGKPAGPKGqlwKSGRRLQLLAQPAVEAPGCGVSSYDDYFSPDNLRERS---SEALLpG-LEPSAGLAQFSCRGGLSQ 220
4_pfamImport 143 RYKRKSA-LAIqlfKSDQSPPSTIRLIPGTPDVEASSYEDYFSPDNLKERN---SERLPpE-AQQLASPSLFHC-RGLSK 216
XP_005334413 362 RLSRKPVTPRSq-lRLERGLLLAARPAPATPDSGE-SYEDYFSPDNLRERG---SEQSVpG--SPLPSPMQLGC-RSLFK 433 thirteen-lined ...
XP_007671505 232 RPSMKLTAAILhqgASEVPSQLKSKSGSETSNSEDASYDDYFSPANLNERTapiSSVFApGrQQKSPGPPRLTQRVSLFR 311 platypus
XP_007476295 376 KSTIKFATPKVhrdKAENFLELMTTPVKVSPACEEAIYEDYFSPTNLKEGN---SKNCTsKvKQILESPSHLNSQKSVYR 452 gray short-tail...
XP_023486251 482 RERTTVLEMSDFSCIGKNPGSIG-ITNLIAKTsss-lqRPTNDERNTTLGFMASEGaSAAGETPGFCGQAVPQTREDM-S 558 horse
2_pfamImport 223 TERTSLLDRADLSLIGRSPRPAV-GTCSTAKP------GPPPFCGAPGVPRRCVGG-GAAEGPPGPCPWAEAQGEGDA-R 293
NP_001096785 456 TERTSLLDRADLSLIGRSPRPAV-STCSTAKP--------ALSGADAGLGGGTSGGtSAADRTPGPCPRAEAQGGGDV-R 525 cattle
XP_025301431 456 RERRNILQMCDFSCLGKHPRSVDvVTGVPAKTsss-lqKPTHKPADAMRGLLTSDGtGAAEDAPGCCQQAAAPRREHG-H 533 dingo
XP_004766810 451 TERRNILHMADFSCVGRSPRSVD-MTDVTAKMsss-leKPPQDTADTTWACLTSEGtCAAEGTPGPCQQAGAHRRAGP-H 527 domestic ferret
5_pfamImport 221 RERRNILQMADFSCIGKNPRLVN-MTDVTAKTscs-lqKPTQDTADAVWGCLTSEGaCAAEGTPGHCQQAGAQRRSGP-C 297
4_pfamImport 217 WERRNMLEMCDFTCIGEKHRSISsISDLISKSass-leKPVKEEVNTASTCLLLVE-TSANDSPGLCSQPGPQLRDDT-G 293
XP_005334413 434 KRAKSLIEMADFSCIGESPRSVP-VTQLTAKTcsq-lqKPEKCAENPGSSRTAAGEtPAAEDGQGGAGQAADARPRR--- 508 thirteen-lined ...
XP_007671505 312 GKRKSLLGKAEATQVCKKKTRLDqVSDGPAEErdaephQPGKWKGVLVAEPASERGiPTAIETPECSSRSDPEKIKSK-T 390 platypus
XP_007476295 453 SKKRSILENSDYPNFSKRIKLIE-TSDNLVEEcnctlkKLPNSERNMSLNCNPYSEiPNANEILGCYNEIDSQERERNiA 531 gray short-tail...
XP_023486251 559 EDGKSIsSCTISELALQKarvakE-------DHGDSTHWKGC---------------NKEM----QELIDIQTRQK-EDT 611 horse
2_pfamImport 294 PAEGDT-LHTPSGLVPQT-----G-------PQGDPSPLTGS---------------REEM----EEWTDPQLTQK-DGA 340
NP_001096785 526 PAGGDA-PQTRSQLIPQT-----G-------PQGDRSPLKGS---------------REET----EEWTDPQSTQK-EGA 572 cattle
XP_025301431 534 PAGEGC-SRVDEELAPPEahggeG-------LHGDLTPLEGS---------------STEM----KGSVDVRSTQK-EDR 585 dingo
XP_004766810 528 AGGRRR-SHMAGEPAVPQghggeG-------LHGDFTPLEGS---------------SVEM----EELLVVRSGQK-EDS 579 domestic ferret
5_pfamImport 298 TDGKSC-SPVDDEPALSQgcggeGlggdfpqLGGDFPPLERS---------------SMEM----TGLLDVRSVQK-EDS 356
4_pfamImport 294 PEGSSH-PDTLSSSAHHI------------------TPLKGN---------------STET----RDPGDGKGSPK-EGS 334
XP_005334413 509 ------------SPAPPE-----E-------REGDLCPPERS---------------GEDV----RGSLCVQSGQE-RGS 544 thirteen-lined ...
XP_007671505 391 DSGTRSkNSRL--------------------RPGELMPRSGSvdggpdafpsverriTENPhpveRASVLAGTREKeDSA 450 platypus
XP_007476295 532 IGGNNC-LHTADESVLMSqylesG-------SCDTLVSLERD---------------SKEVltnkKESIIPMNIQKkENI 588 gray short-tail...
XP_023486251 612 ASKMLNSSEgeTQS-----NYKLNFVGDCNVEKSTEESENLPRGCS 652 horse
2_pfamImport 341 PPGTAESAA--AHS-----EGELSAAGDRAEGRSAGAREAPAQGSS 379
NP_001096785 573 PPETTESAA--VHS-----EGKPSAAGGYAEDRPAGARGAPAHGSS 611 cattle
XP_025301431 586 ASRPWSSSGgeVQC---------GFVSEGTVDTPAGDKEHSSTGGD 622 dingo
XP_004766810 580 TSRMWNSSGgeMQC-----DRELDLVPDCTVDKAAEGGPQPSSACD 620 domestic ferret
5_pfamImport 357 TSGTWKSSGaeMQR-----DYELDFVGDRTVGKAAEEREHSASRHD 397
4_pfamImport 335 TPPASASPEdeVHI------CNLSLGEDCNVEKSVEEKENIATGYS 374
XP_005334413 545 PSSVLDPVNagCFT------SKLNFEADYNVEKSTEEKENLPTAYS 584 thirteen-lined ground squirrel
XP_007671505 451 NSETFSSGEgeTPTakvteEHRLPFKDGSDVEGSTEEKESQPRTCV 496 platypus
XP_007476295 589 NSEVFNSCEskKQ------DFNFIFKSDAALEKSVKEMENPSRYIQ 628 gray short-tailed opossum
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