1EP2


Conserved Protein Domain Family
DHOD_e_trans
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cd06218: DHOD_e_trans 
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FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.
Links
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Statistics
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PSSM-Id: 99814
Aligned: 89 rows
Threshold Bit Score: 228.584
Created: 28-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          # ####                 ###   
1EP2_B        9 VVSQREVay-----nIFEMVLKgtlv--demDLPGQFLHLavpn---gamLLRRPISISSwdk----rakTCTILYRIGD 74  Lactococcus lactis
ZP_01090121  24 VVENVQLar-----dTYRIRFAcpsl--aasITPGQFVMLrlad--mqdpLLGRPLAMYDvyrdadgaavGIDVVYLVHG 94  Blastopirellula ...
ZP_02061173   8 ILKNEKVgm-----hTYLMVLKlnh---sydIKPGHFVMIkpnd--sfdpLNRRAFAIADve------edAIYIYYDVIG 71  Hydrogenobaculum...
ZP_01853786  20 VVEQERMaq-----dTYRLRLEcpev--aqvILPGQFFMVrepg--vndpLLGRPFALYDtcldengtaiGLDFGYVVVG 90  Planctomyces mar...
ZP_01906308  14 VVANRALtg-----gYFVLELAseqdnavggAQPGQFVMLrgew--grdlLNGRAFSVLEaid-----arRFTVMLKVFG 81  Plesiocystis pac...
NP_864564    20 LIRNEAIae-----nTHLLRVAapei--arsFRPGQFVMIrmtg--vnapLIGRAFAIYDvhagadgqpeSIDLIYLRKG 90  Rhodopirellula b...
EDP74206      9 ITENRFIsg-----iTWLLKFKnkei--aekAKPAHFIMVrptaeyqydpMMRRAFAIADvv------ddEIWIYYDVYG 75  Hydrogenivirga s...
O67329        9 VLENTYIsg-----nLYRLTLRipdk-ilkqIEPGHFAMIkpsd--tydpMGRRAFAVADie------ehKAVFYYDVYG 74  Aquifex aeolicus
YP_012523    11 VLDLVPFgltsgearFYALRLErpd---wgtWAPGQFVMLrpagw-aldmLWARPFSICRvs------rrDLVIFFQVVG 80  Desulfovibrio vu...
ZP_02732860   8 VLEHTKLaa-----rTYRVRLRapei--aaaIRPGQFVMLrlpg--tsdpLLGRPFALYDtvlen-gqpvAIDVVYLVVG 77  Gemmata obscurig...

Feature 1         ###                                             #                             
1EP2_B       75 ETTGTYKLsklesGAKVDVMGPLGNGFPVaev------tstDKILIIGGGIGVPPLYELAKQlek-------------tg 135 Lactococcus lactis
ZP_01090121  95 KLTSKLARca--pGQRLEVWGPLGNGFPGqq---------vDHLIMVAGGIGQTPFVALGKEylgrqaygd-pprqgasa 162 Blastopirellula ...
ZP_02061173  72 KGTTVMSTlr--eGEFVDVLMPLGNGLFEas--------rdKLNVVLAGGIGISGVSLFCRLlke-------------kn 128 Hydrogenobaculum...
ZP_01853786  91 KLTSRMTHwq--pGDRVEIWGPLGNGFPYpg---------sGSLVMVAGGIGQTPFLATARQalglrkygqpeqtlsalp 159 Planctomyces mar...
ZP_01906308  82 RGTGKMREmq--pGERMTVTGPLGRGFPQpdaqpdggagsgRKQLLVAGGVGLPPLHFHARRlvgr-----------gka 148 Plesiocystis pac...
NP_864564    91 ALTVPLSEap--vGTMVTVWGPLGNGFDDrp---------cDRLIMAVGGIGQTPMLAAGRDatqr-----------gwa 148 Rhodopirellula b...
EDP74206     76 RGTKALTEkk--vGDEIEILAPLGKNLFPek---------fDYYILVGGGIGFAGLSYLMKKlrn-------------en 131 Hydrogenivirga s...
O67329       75 KGTYLLSKrk--pGERLKTFLPLGKRLFSye---------gDKHLLIGGGVGLAGLTLLAKKlrd-------------mg 130 Aquifex aeolicus
YP_012523    81 RGTRRLAElh--aGDTVHVWGPLGNSFAVep---------dTPTLLLAGGIGIAPFIGYVHEhpk--------------p 135 Desulfovibrio vu...
ZP_02732860  78 KMTGRLVEvn--aGEPLQVWGPLGKPFLDtg--------paDRVTLVAGGIGQTPFLAFAREllgargfgg--daprpra 145 Gemmata obscurig...

Feature 1                                                                                       
1EP2_B      136 cQMTILLGFASEnv-----kILENEFsnlknvTLKIATDDGs-------yGTKGHVGMLMNEIdfe--------vdaLYT 195 Lactococcus lactis
ZP_01090121 163 gKVTMCYGARSAey-----lAGVEDFrac-giDVKISTDDGs-------aGHHGLVTDLLNAAldast-----agvqIAC 224 Blastopirellula ...
ZP_02061173 129 lDFKVYYGARSKey-----lVMLDWFsky-siPIEVYTDDGs-------fGKKGFVTDALKDIen----------anVYA 185 Hydrogenobaculum...
ZP_01853786 160 eRVSLLYGARSKey-----lAGLDDFqle-glDVSVATDDGs-------yGHQGFVTELLQQQiesds-----ppatVFC 221 Planctomyces mar...
ZP_01906308 149 dAVEMFYGGRSAae-----lVLTEALdew-gvQTVLATDDGs-------rGVEGRVTVPLTARldaaae--ageaveILA 213 Plesiocystis pac...
NP_864564   149 kKVELIYGARRAsl-----lAGVDDFrsa-gfEVTTCTDDGs-------eGRAARVPDVLADRlqslqnespgtrirVIT 215 Rhodopirellula b...
EDP74206    132 kPFKAIYGVRRKqqlsmldwIKENGFe----nDVIIYTEDGs-------yGEKGLVIRDLKELalen------kntvIFT 194 Hydrogenivirga s...
O67329      131 kKVFIAYGGRSRehlgmvewLEKEEF------PYELFTNDGs-------aGRKGFVTEILKEFstd---------wvVHA 188 Aquifex aeolicus
YP_012523   136 wNVWMDFGHRMP--------LGCYPFds---iSDRIMADTHmeecpedlqKFIDLLGSRMAEFaek--------qglVLA 196 Desulfovibrio vu...
ZP_02732860 146 kQVALYYGVRSAel-----aAGVEDFraa-gvEVHLASDDGs-------vGTKGFVTQLLESHgpt---------gpLVG 203 Gemmata obscurig...

Feature 1                                 ##                                       
1EP2_B      196 CGAPAMLKAVAKKydq-lerLYISMESRMACGIGACYACVEHdked------eshALKVCEDGPVFL 255 Lactococcus lactis
ZP_01090121 225 CGPERMMESVATIaaqrnvpCWVSLETPMACGIGICFTCVAKvrqdd----gswdYKRTCVEGPIFA 287 Blastopirellula marina DSM 3645
ZP_02061173 186 CGPSPMLKAVQNIskqkgfdAYLSLENPMACGYGVCLGCVVKts---------dgYVRTCVEGPVFK 243 Hydrogenobaculum sp. Y04AAS1
ZP_01853786 222 CGPEPMMEAVSRItsqagisCWLSLETPMACGFGACFSCVAKvrisd----dewdYRRTCVEGPVFN 284 Planctomyces maris DSM 8797
ZP_01906308 214 CGPTPMLAAVRELglargvpTSLCLEEMMACGFGVCLGCAVPvyg-------pkpYKYCCTDGPVFD 273 Plesiocystis pacifica SIR-1
NP_864564   216 CGPEIMMEKSSEVcerlgvdCQVSMETPMACGIGICFSCVAKvkqdd----gewdYKRTCVEGPIFD 278 Rhodopirellula baltica SH 1
EDP74206    195 CGPHGMMKAVDKIakeinipCYASLESKMACGFGICIGCVIKdve-------knsYVRVCYEGPVFD 254 Hydrogenivirga sp. 128-5-R1-1
O67329      189 CGPKPMLKTIKEMktg--hkVYFSLEERMACGWGVCLGCVVKtrd--------gkFKRVCYEGPVMP 245 Aquifex aeolicus
YP_012523   197 CGPTPFLKTVRDLalhhgvrTQLSLETRMACGVGACLGCVCRttekwpdpakaegRVQTCTSGPIFW 263 Desulfovibrio vulgaris subsp....
ZP_02732860 204 CGPEPMLHALAKLaarwnvpCQVSLETPMACGIGVCFSCVAKvktp-----dgddYKRVCVDGPCFD 265 Gemmata obscuriglobus UQM 2246

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