cd05162: PWWP (this model, PSSM-Id:99894 is obsolete and has been replaced by 438958)
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. The function of the PWWP domain is still not known precisely; however, based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.
Comment:Possible chromatin binding property is supported by its charasteristic electrostatic charge distribution. Upon binding, the charged surfaces may form nonspecific contacts with the nucleic acid on the basic side and contact the core histone molecules along the acidic surface.
Jiyao W et al.(2023). "The conserved domain database in 2023.",