2I7K


Conserved Protein Domain Family
Bromo_brd7_like
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cd05513: Bromo_brd7_like 
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Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Links
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Statistics
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PSSM-Id: 99945
Aligned: 10 rows
Threshold Bit Score: 173.75
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #    #  #                                      #   #   
2I7K_A          8 PLQEALNQLMRQLQRkDPSAFFSFPVtDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPE 87   human
CAG31781      135 PLQEALNQLMRQLQRkDPSSFFSFPVtDFIAPGYSMIIKNPMDFSTMKEKIKNNGYQSIEELKDNFKLMCTNAMTYNKPD 214  chicken
NP_037395     135 PLQEALNQLMRQLQRkDPSAFFSFPVtDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPE 214  human
AAH70751      138 PLQEALNQLVRQLQRkDPGAFFSFPVtDFIAPGYSLIIKNPMDFSTMKEKIRNCEYRSIEEFKENFKQICHNAMIYNKPG 217  African clawe...
AAH55611      129 PLQEALSQLIRQLQRkDPSAFFSFPVtDLIAPGYSIIIKKPMDFSTIKEKVKKEQYQSLEELKLDFRVMCENAMIYNKPE 208  zebrafish
AAF52557      279 PLNKLLEHLLRFLEKrDPHQFFAWPVtDDMAPGYSSIISRPMDFSTMRQKIDDHEYTALTEFTDDFKLMCENAIKYNHVD 358  fruit fly
XP_785066     159 PILKVLENLQKTLQRkDVDGFFAWPVnDIIAPGYSSIILQPMDFCTMKKKIEREDYNSIDEYKDDFVTMCENAMKYNRPE 238  purple urchin
XP_001638034  160 ALQLCLENLHITLQRkDIQGFFAYPVnDAIAPGYSRVITHPMDFSTIKTKIDSNSYTTIEAFRDDFYLMCNNAMVYNAPD 239  starlet sea a...
XP_640031     265 HYKKIFGQIIQLLMKkDTHGFFYSPVtEQIAPNYFKYIREPMDFETMLKKNKEFRYLNIDKFQYDFTLICENCMKYNDSA 344  Dictyostelium...
XP_969635     149 PVQRMLDQLLGLLEKkDPQQFFAWPVtDNIAPGYSSIITQPMDFSTMRQKIEDNQYDNLQDFNADFKLMCTNAMKYNHVD 228  red flour beetle

Feature 1           #               
2I7K_A         88 TIYYKAAKKLLHSGMKIL 105  human
CAG31781      215 TIYYKAAKKLLHSGMKIL 232  chicken
NP_037395     215 TIYYKAAKKLLHSGMKIL 232  human
AAH70751      218 TIYYRAAKKLLNSGIKIL 235  African clawed frog
AAH55611      209 TIYYKAAKKLLHSGMKIL 226  zebrafish
AAF52557      359 TVYNKAAKRLLQVGMKHL 376  fruit fly
XP_785066     239 TVYYKAAKKLLGTGLKVM 256  purple urchin
XP_001638034  240 TIYFKAAKRIMQIGAKMM 257  starlet sea anemone
XP_640031     345 SVYYKEAKRLLTNGRSII 362  Dictyostelium discoideum AX4
XP_969635     229 TIYYKASKKLLHAGSKMM 246  red flour beetle

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