Conserved Protein Domain Family
Bromo_polybromo_IV

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cd05518: Bromo_polybromo_IV 
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99949
View PSSM: cd05518
Aligned: 9 rows
Threshold Bit Score: 186.882
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #    #  #                                      # 
AAP34197      519 RKQRMKILFNVVLEarepgsGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNAR 598  human
CAG06951      588 KKNRMKALFAAVTEareagtSRRLCDLFMVKPSKKDYPDYYKVILEPMDLRTIEQNIRNERYNTEEALMDDMKLMFRNAR 667  Tetraodon nig...
951231        517 RKQRMKILYNAVLEaresgtGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKMIEHNIRNDKYVGEEAMIDDMKLMFRNAR 596  chicken
AAH84946      542 RKQRMKILFNTVLEarepatGRRLCELFMFKPSKKDYPDYYKIILEPMDLKTMEQNIRSEKYATEETMMNDMKLMFRNAM 621  African clawe...
AAF56339      512 IKKKILSIQKYLVDys--lgNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCR 589  fruit fly
XP_625055     529 LKKRLYALVKCVIEyv--vnGRQPMLMFMEKPSKKLYPDYYQVIAEPIDMLAIEANIKAEKYQNENELIQDFKLMFNNCR 606  honey bee
EAT48776      503 LRKKLLSLHEYMLQyt--vnGRQPMGLFIEKPSKKLYPDYYQVIQHPIDMTTIENNIKSDRYGVLDDAVGDYRLMFSNCR 580  yellow fever ...
XP_001626082  482 SHPLYLFINLYLFTpqd-gsGRQLCIIFQKLPSRAEYPDYYKVISEPVCLSQIEGNIRDNKYATEEELLLDFEVMFDNAR 560  starlet sea a...
XP_796375     576 QKSKLMALYLSLVHyke-esGRSPITLFMEKPSKKEYPDYYHIITEPIDMKTIETNIKNEKYQTEEGVMKDFSLMFDNAR 654  purple urchin
Feature 1           #     #               
AAP34197      599 HYNEEGSQVYNDAHILEKLLKEKR 622  human
CAG06951      668 HYNEEGSQVYNDADILEKILKDKR 691  Tetraodon nigroviridis
951231        597 HYNEEGSQVYNDAHMLEKILKEKR 620  chicken
AAH84946      622 HYNEEGSQVYNDAHVLEKFLKDKK 645  African clawed frog
AAF56339      590 QYNEEGSNIYEDANILERALNEKL 613  fruit fly
XP_625055     607 QYNEEGSLIYEDANTLERVLMDKV 630  honey bee
EAT48776      581 KYNEEGSMIYEDANILEKALNEKL 604  yellow fever mosquito
XP_001626082  561 YYNEEESQVYQDACLLEKVLRKKK 584  starlet sea anemone
XP_796375     655 HYNEEGSMVYEDANLLEALLKDKF 678  purple urchin

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