Conserved Protein Domain Family
Bromo_Rsc1_2_II

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cd05522: Bromo_Rsc1_2_II 
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99953
View PSSM: cd05522
Aligned: 19 rows
Threshold Bit Score: 146.617
Threshold Setting Gi: 27803071
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #    #  #                                      
CAD60774      334 PLEARTQSLLKGLRRFKSDdg--qLRILSFERLPDKADMPDYYASIRNPIALDTIKKKHKRKkYTTIDQVLQDLELMFGN 411  Podospora ans...
XP_445094     262 PYVQRMKNVLKVIRKEVDErr--rSLLDSFEKIPDRNYNPQYYSIISNPISLDEIRKKVKTRkYKDFEGFHNDIKLMLSN 339  Candida glabr...
12230583      276 PYIQRMKNVMKVLKKEVLDsg--iGLTDLFERLPDRHRDANYYIMIANPISLQDINKKVKTRrYKTFQEFQNDFNLMLTN 353  baker's yeast
XP_457743     244 PYETRIKLILKHFKKLRHPndpnhPLSIHFDRLPDPKTNSNYYQVIKQPISLNEIRTKVRTRkYHNVDEFISDLNLMFQN 323  Debaryomyces ...
1723670       236 PYVLRIKNILKMMRREVDQnn--kTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRkYRNFHTFEEDFQLMLTN 313  baker's yeast
XP_721463     228 PFETRIKLILKGFKKLRDNng--hPLTKHFEKLPDIKTHGDYYERIAAPISLNEIRIKVRSRkYSSVELFINDLDLMFAN 305  Candida albic...
NP_982942     233 PYEQRIKNVLKNLKRETLSgs-reFLTLHFDRLPDEEREPQYYTVISNPLSLDDIRKRVKQRkYKDFLAFQQDVGLMLNN 311  Ashbya gossyp...
XP_001643343  318 PYVQRIKNIFKMLRKVVDQag--ePLTLTFEKLPSKESFPQYYQLIKNPISLEDIRKKVKTRkYKDFKTFHDEMNLMLSN 395  Vanderwaltozy...
XP_001643414  253 PYVQRMKNVIKMLRRETDEsk--rQLTATFEKIPDEHEETKYLSIISNPMPLEEIFKKVKTRkYKDFQGFQNDMNLMVAN 330  Vanderwaltozy...
XP_001383373  228 PFETRIKLILKSFKKLRDPnnesrSLTQHFDKLPDTKTNPSYYHTITNPISLFEIKVKVRTRkYTSVDQFIHDLDVMFSN 307  Pichia stipit...
Feature 1         #   #       #               
CAD60774      412 AMQFNEEG--SQVHEDATELLKQARLLT 437  Podospora anserina
XP_445094     340 YRTYNKNN--PNELKRSFKFEKSFNELA 365  Candida glabrata CBS 138
12230583      354 FRISHRGD--PESIKISNILEKTFTSLA 379  baker's yeast
XP_457743     324 TKFYFSNDqlSPTFQDCLLFESEANNVI 351  Debaryomyces hansenii CBS767
1723670       314 FKLYYSQD--QSNIIRAQLLEKNFNRLV 339  baker's yeast
XP_721463     306 AQLYYENDpySEEFLDSQQFKKEAHLVI 333  Candida albicans SC5314
NP_982942     312 YRMYHRSQ--PQEMRRAAEFEAKFTDFA 337  Ashbya gossypii ATCC 10895
XP_001643343  396 YKIANLNS--PHNLKRHALLEKDFNLMV 421  Vanderwaltozyma polyspora DSM 70294
XP_001643414  331 YKLYYRSN--PQALKRANLLERRFAEYS 356  Vanderwaltozyma polyspora DSM 70294
XP_001383373  308 FQMFYQNDpySEEFIDFQNFNREAHAII 335  Pichia stipitis CBS 6054

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