1XVI,4BND


Conserved Protein Domain Family
HAD-SF-IIB

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TIGR01484: HAD-SF-IIB 
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HAD-superfamily hydrolase, subfamily IIB
This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class II subfamilies are characterized by a domain that is located between the second and third conserved catalytic motifs of the superfamily domain. The IIB subfamily is distinguished from the IIA subfamily (TIGR01460) by homology and the predicted secondary structure of this domain by PSI-PRED. The IIB subfamily's Class II domain has the following predicted structure: Helix-Sheet-Sheet-(Helix or Sheet)-Helix-Sheet-(variable)-Helix-Sheet-Sheet. The IIB subfamily consists of Trehalose-6-phosphatase (TIGR00685), plant and cyanobacterial Sucrose-phosphatase and a closely related group of bacterial and archaeal sequences, eukaryotic phosphomannomutase (pfam03332), a large subfamily ("Cof-like hydrolases", TIGR00099) containing many closely related bacterial sequences, a hypothetical equivalog containing the E. coli YedP protein, as well as two small clusters containing OMNI|TC0379 and OMNI|SA2196 whose relationship to the other groups is unclear. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 273651
Aligned: 21 rows
Threshold Bit Score: 104.385
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XVI_A        11 LVFSDLDGTLL-DSHs----YD-WQPAAPw-LTRLREAn-VPVILCSSKTSAEMLYLQK--Tl-gLq--gLPLIAENGAV 77  Escherichia col...
CAD08916       4 LAAFDMDGTLL-MPD-----HH-LGRETIatLSRLRERd-ITLTFATGRHVLEMRHILGtlS---Ld---AYLITGNGTR 69  Salmonella ente...
BAA19164      14 LVLFDVDGTLT-PAR-----LS-VSPEMLetLQNLRKV--VAIGFVGGSDLSKQQEQLS------Vn--gENVIDSFDYA 76  fission yeast
AAK04668       4 ILSFDIDNTLN-EPK----------MPIFpeMAELLATlsQKYIIAPISGQKYDQFLIQiiN---Nl--pESANLDNFHL 67  Lactococcus lac...
P43051        13 LFAIDLDGTLLaDSAn----GT-VHPKTEeaIKKAVAQg-HIVSIITGRPWRSTLPVYE--Kl-gLn---AIVGNYNGAH 80  Mycoplasma hominis
WP_001835415   7 LLLFDFDETYF-KHNtneedLS-HLREMEklLEKLTNNneVITAVLTGSTFQSVMDKMD--Qv-nMtfkpLHIFSDLSSK 81  Staphylococcus ...
NP_001105006  11 MIVSDLDHTMV-DHHd----EEnLSLLRFgaLWESVYCedSLLVFSTGRSPTLYKELRK--E--------KPMLTPDITI 75  Zea mays
WP_010905232   6 HIFSDLDGTLL-DDQ----------GKISkkTQEVIENsnLPFSLVSARAPQAMESLIN--Ql-nLk---SSQVAFNGGL 68  Lactococcus lactis
WP_010230289   6 LLVTDIDGTIT--HQp----HQ-LDDRVIeaLYQYHEAg-WDLFFLTGRYFSYAYPLFQ--Nl-sVp---FLLGSQNGSS 71  Chlamydia murid...
4BND_A         5 ILSFDIDNTLN-EPK----------MPIFpeMAELLATlsQKYIIAPISGQKYDQFLIQ--IinnLp---ESANLDNFHL 68  Lactococcus lac...
1XVI_A        78 IQLAEQWQEI------DGFPRIISG---Is--hGEISLVLNTLreK--E--HFk-------F-------TTFDDVDDATI 128 Escherichia col...
CAD08916      70 IHSLEGDVLHrqd-ldPQVADTVMH---Ha---WDTRASMHVF--N--D--NGw-------F-------TGQEIPALLQA 122 Salmonella ente...
BAA19164      77 FAENGLTAYRygqqlaSQSFIAWLGeekYq---KLVNFCLHYI--AdlD--IPvk-----rG-------TFIEFRNGMIN 137 fission yeast
AAK04668      68 FVAQGTQYYAhkdgewKQVFNYALTdeqAn---AIMGALEKAA--KelG--HWdesvlapgD-------EINENRESMIA 133 Lactococcus lac...
P43051        81 IHNPADPFFIpai-tyLDLNEVLYI---LgdekVKKEITNYAI--E--Gp-DWv-------Q-------LMHRDPNLERV 137 Mycoplasma hominis
WP_001835415  82 MFTWNNGEYVe----sETYKKKVLS---EpflfEDIEDILRHI--S--A--QYnve--fipQ-------RAFEGNETHYN 139 Staphylococcus ...
NP_001105006  76 MSVGTEITYGeam-vpDDGWEEYLN---NkwdrNIVVAETVSF--S--E--LKl-------Q-------PETEQRPHKVS 131 Zea mays
WP_010905232  69 IFAKNEVIKAnpm-vhASAQELIKT---IkkdyPEINLSLYSL--S--D--WYv-------E-------KIDKDIEQEMQ 124 Lactococcus lactis
WP_010230289  72 VWSSTEKEFIyfqnmpRDFLRVLER---YfeglDLIVCIESGA--SnrD--TYfrq--glgN-------KTRELKAILDT 135 Chlamydia murid...
4BND_A        69 FVAQGTQYYAhkagewKQVFNYALT---DeqanAIMGALEKAA--K--ElgHWd-------EsvllpgdEINENRESMIA 134 Lactococcus lac...
1XVI_A       129 AEWTGl-----------sRSQAaLTQLHEASVTLIWRdsd----erM--------AQFTARlnelg------lqfmQ--- 176 Escherichia col...
CAD08916     123 HVYSGf------------RYQV-IDIKSIPAHQVTKIcfcg-dhddL--------IRLRIQ---------------Lnea 165 Salmonella ente...
BAA19164     138 ISPVGrn---------anTEER-NEFERFDKGRKIRAtmvdvlrekF--------KDYGLT---------------Fsi- 183 fission yeast
AAK04668     134 YSAIGqka-------gveAKQA-WDPDMTKRNEIAKLas-----qyA--------PEFEFE---------------Va-- 175 Lactococcus lac...
P43051       138 FGFNQa-----------tKFRE-CINLEKIPLKPTGIv--------FdvkpdtdvLELLTYlkrrygdlgefsswsK--- 194 Mycoplasma hominis
WP_001835415 140 FYFHSt------------GNHN-NDSRILEALVRY-An--------D--------QNYTARfsrsnp----lagdpE--- 182 Staphylococcus ...
NP_001105006 132 F-FVDk-----------kNAQE-VIKSVAERLDKCG-------------------LDAKIIy------------------ 161 Zea mays
WP_010905232 125 FTPQVpk----------lVDLE-TLITERPRLEIFKIl--------LitpnesklEEIKKHleklnfp--diiiqkT--- 180 Lactococcus lactis
WP_010230289 136 VYFPSeesaellvdvqgcLSDE-FTYENFAVAKFFGRreev-kkimD--------RFVEAPev------------sSrvt 193 Chlamydia murid...
4BND_A       135 YSAIGqka-------gveAKQA-WDPDMTKRNEIAKLas-----qyA--------PEFEFEv-------------aG--- 177 Lactococcus lac...
1XVI_A       177 ----------GARFWHVLD---ASAGKDQAANWIIATY---QqlsGKRPTTLGLGD----GPNDAPLLEVMDYAVIV 233 Escherichia coli K-12
CAD08916     166 leerahlcfsAVDCLEVLP---LGCNKGSALAVLSNHL---G---LSLADCMAFGD----AMNDREMLGSVGRGLIM 229 Salmonella enteric...
BAA19164     184 ---------gGQISFDVFP---AGWDKTYCLQHVEKEG---F------DTIHFFGDktykGGNDYEIFVDPRTIGHS 239 fission yeast
AAK04668     176 ---------gTTTINGFVP----GQNKEFGMNHLMEEL---N---VTKEEILYFGDmtqpGGNDYPVVQMGIETITV 233 Lactococcus lactis...
P43051       195 ----------GEGLSPVFDitsIGIDKGKVISLIMRYY---N---IDIDDTVAMGD----SYNDLSMYNVANVCVSP 251 Mycoplasma hominis
WP_001835415 183 ----------NAYDIDFTP---SNAGKLYATQFLMKKY---N---IPVKSILGFGD----SGNDEAYLSYLEHAYLM 236 Staphylococcus aureus
NP_001105006 162 ---------sGGQDLDILP---QGAGKGQALAYLLEKLsscG---KPPNNTLVCGD----SGNDAELFSIPGVHGVM 219 Zea mays
WP_010905232 181 ----------WETYLEITH---LEAQKAKAVQFIAQRE---Q---LEQSELAAFGD----NENDLSMLKAVGLPIVM 234 Lactococcus lactis
WP_010230289 194 mny-mrwpfdFNYAVLLLTl--KDISKGFAVDQVVHTF---Yk--GNKPFIMASGD----DANDIDLLSRGDFRIVM 258 Chlamydia muridarum
4BND_A       178 ----------TTTINGFVP----GQNKEFGMNHLMEEL---N---VTKEEILYFGDmtqpGGNDYPVVQMGIETITV 234 Lactococcus lactis...
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