1XKP


Conserved Protein Domain Family
type_III_SycN
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TIGR02503: type_III_SycN 
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type III secretion chaperone SycN
Members of this protein family are part of the machinery of bacterial type III secretion in a number of bacteria that target animal cells. In the well-studied system from Yersinia, a complex of this protein (SycN) and YscB (pfam07329) acts as a chaperone for the export of YopN (). YopN then acts to control effector protein secretion, in response to calcium levels, so that secretion occurs only after contact with the targeted eukaryotic cell. [Protein fate, Protein folding and stabilization, Cellular processes, Pathogenesis]
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Statistics
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PSSM-Id: 131555
Aligned: 7 rows
Threshold Bit Score: 116.028
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XKP_B         4 IEPIISHFCQDLGVPTSSPLSP-LIQLEMAQSGTLQLEQHGATLTLWLARSLAWHRCEDAMVXALTLTAAQXSGALPLRA 82  Yersinia pestis
Q52095         4 IEPIISHFCQDLGVPTSSPLSP-LIQLEMAQSGTLQLEQHGATLTLWLARSLAWHQCEDAMVKALTLTAAQKSGALPLRA 82  Yersinia entero...
AAS94480       2 LQDTIAAFARRMGMTGFVPSAGgLAAFDIDGVGRLYVEPSDDTLLVYLARAVPAHET-HLPRRLLDLSHYRHAWPLPLQG 80  Desulfovibrio v...
CAE42533       4 ADRALHQFGQDIGIEGLAFGPSgSASLALSNGRRLGVECVAGAALVHLAQRVERDAA-SVLLAAWKRAHGQRGSAASIQT 82  Bordetella pert...
AAQ60271       5 TARRLEQFLQLSELPTPRVEPR--MEFSMP-PFRLYIEYLDGRVLLSLARSIEHVHQSEALKRLLASCQPARTQGTPLRA 81  Chromobacterium...
WP_003113546   4 VELAVAQFCQDLRVSVPAPLAR-VVQLDFEDSGTLQLERHGEQLSLWLACDLAWHQAYRGTLRALRLCHARAAGSLPLRC 82  Pseudomonas
AAS13315       4 IDASVDDFCRGMGLEAVDFSSAgRVQLSFEQSGTLHIEKHQDCLFLMLAKPLPWHQSNELIKKALSFCHAGQGWPFLIKT 83  Vibrio harveyi

1XKP_B        83 GWLGE---SQLVLFVSLDERSLTLPLLHQAFEQLLRLQQEVLA 122 Yersinia pestis
Q52095        83 GWLGE---NQLVLFVSLDERSLTLPLLHQAFEQLLRLQQEVLA 122 Yersinia enterocolitica
AAS94480      81 GMHG----GQAVVLTRLDGRTATAVDVENAAVLLAGVLDRATA 119 Desulfovibrio vulgaris str. Hildenborough
CAE42533      83 SLWSEgseDWIVAQTRLPERSLDAAALRLAVLGLTNWLDRLEA 125 Bordetella pertussis Tohama I
AAQ60271      82 YILRD---QQVLSCAPSAG---SETNHWLACVQTMRRLLEATA 118 Chromobacterium violaceum ATCC 12472
WP_003113546  83 AWSGE---SRLLLCITLEARQVGMPTLHQALQALRSARSEVLA 122 Pseudomonas
AAS13315      84 GLLDE---QTMVFSAQIEGDEVTLPTIEQAFALLVRLHKDVVG 123 Vibrio harveyi
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