1D2M,1D9Z,1FUU,1A1V,1CU1,1HV8,1GM5


Conserved Protein Domain Family
HELICc
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cd00079: HELICc (this model, PSSM-Id:238034 is obsolete)
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Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may not be an autonomously folding unit, but an integral part of the helicase; 4 helicase superfamilies at present according to the organization of their signature motifs; all helicases share the ability to unwind nucleic acid duplexes with a distinct directional polarity; they utilize the free energy from nucleoside triphosphate hydrolysis to fuel their translocation along DNA, unwinding the duplex in the process
Links
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Statistics
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PSSM-Id: 238034
Aligned: 130 rows
Threshold Bit Score: 46.4621
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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nucleotideATP-binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding region [chemical binding site]
Evidence:
  • Structure:1A1V; Hepatitis C virus NS3 RNA helicase domain complexed with ssDNA oligonucleotide
    - View structure with Cn3D
  • Citation:PMID 9493270
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              ####                    ##              
1D2M_A     414 DPLVRVKPTe----nQILDL-MEGIReraa-rgeRTLVTVLTVRMAEELTSFLVe-hGIRARYLHHeld--afKRQAlir 484  Thermus thermoph...
1A1V_A     170 NIEEVALSTtgeipfYGKAIpLEVIKg------gRHLIFCHSKKKCDELAAKLVa-lGINAVAYYRg-----lDVSVi-- 235  Hepatitis C virus
2506239    478 EGDNATWWNfd---pRVEWL-MGYLTshr---sqKVLVICAKAATALQLEQVLRe-rEGIRAAVFHegm-siiERDRaaa 548  Escherichia coli
417308    1620 ECGIGEEDId-----KKASQ-DQNFPiqnvisqhRALIFCQLKDMLDMVENDLFkkyMPSVTYMRLdgsidprDRQKvvr 1693 baker's yeast
1723929   1290 SMDRFITESa-----KLRKL-DELLVklks-eghRVLIYFQMTKMMDLMEEYLT---YRQYNHIRLdgsskleDRRDlvh 1359 baker's yeast
1176015    594 TLETLLKTSg-----KLQIL-QKLIPplis-eghKVLIYSQFVNMLDLIEDWCD---LNSFATFRIdgsvnneTRKDqle 663  baker's yeast
1173466    388 TDQHLVDNSg-----KMVVL-DKLLMkfke-qgsRVLIFSQFSRMLDLLEDFCW---WRHYEYCRLdgstpheDRSNaie 457  Caenorhabditis e...
416959     828 EEDQFGYWKrs---gKMIVV-ESLLKiwhk-qgqRVLLFSQSRQMLDILEVFLR---AQKYTYLKMdgtttiaSRQPlit 899  human
417373     780 RGNSDLLFRva---gKFELL-DRVLPkfka-sghRVLMFFQMTQVMDIMEDFLR---MKDLKYMRLdgstkteERTEmln 851  baker's yeast
Q24368     422 TDTHLVYNSg-----KMAIL-DKLLPklqe-qgsRVLIFSQMTRMLDILEDYCH---WRNYNYCRLdgqtpheDRNRqiq 491  fruit fly

Feature 1                     ###                                                              
1D2M_A     485 dLRLGh---yDCLVGINLLREGLDIPeVSLVAILDadke----------------gflRSERSLIQTIGRAARNA-RGEV 544  Thermus thermoph...
1A1V_A     236 -PTSGd----VVVVATDALMTGFTGD-FDSVIDCNtxvtqtvdfsldptftietttlpQDAVSRTQRRGRTGRGK-PGIY 308  Hepatitis C virus
2506239    549 wFAEEdt-gaQVLLCSEIGSEGRNFQfASHMVMFDl---------------------pFNPDLLEQRIGRLDRIGqAHDI 606  Escherichia coli
417308    1694 kFNEDps-idCLLLTTKVGGLGLNLTgADTVIFVEh---------------------dWNPMNDLQAMDRAHRIGqKKVV 1751 baker's yeast
1723929   1360 dWQTNpe-ifVFLLSTRAGGLGINLTaADTVIFYDs---------------------dWNPTIDSQAMDRAHRLGqTRQV 1417 baker's yeast
1176015    664 kFNSSkdkhnIFLLSTRAAGLGINLVgADTVVLFDs---------------------dWNPQVDLQAMDRCHRIGqESPV 722  baker's yeast
1173466    458 aYNAPdskkfIFMLTTRAGGLGINLAtADVVIIYDs---------------------dWNPQSDLQAMDRAHRIGqKKQV 516  Caenorhabditis e...
416959     900 rYNEDts-ifVFLLTTRVGGLGVNLTgANRVVIYDp---------------------dWNPSTDTQARERAWRIGqKKQV 957  human
417373     852 aFNAPdsdyfCFLLSTRAGGLGLNLQtADTVIIFDt---------------------dWNPHQDLQAQDRAHRIGqKNEV 910  baker's yeast
Q24368     492 eFNMDnsakfLFMLSTRAGGLGINLAtADVVIIYDs---------------------dWNPQMDLQAMDRAHRIGqKKQV 550  fruit fly

Feature 1         
1D2M_A     545 WLY 547  Thermus thermophilus
1A1V_A     309 RFV 311  Hepatitis C virus
2506239    607 QIH 609  Escherichia coli
417308    1752 NVY 1754 baker's yeast
1723929   1418 TVY 1420 baker's yeast
1176015    723 IVY 725  baker's yeast
1173466    517 RVF 519  Caenorhabditis elegans
416959     958 TVY 960  human
417373     911 RIL 913  baker's yeast
Q24368     551 RVF 553  fruit fly

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