1VBB,1EAH,1D4M,1EAH,1BEV,1R09,1D4M,1R1A,2MEV,1R1A,1EV1,1R1A,1BEV,1EAH,1D4M,1TMF,1R09,1R09,1QQP,1B35,1BEV,2MEV,1TME,1TME,1B35,1QQP,1FMD,1QQP


Conserved Protein Domain Family
rhv_like
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cd00205: rhv_like 
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Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A virus, rhinovirus, foot-and-mouth disease virus and encephalomyocarditis virus; common structure is an 8-stranded beta sandwich
Links
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Statistics
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PSSM-Id: 119412
Aligned: 102 rows
Threshold Bit Score: 63.9544
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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drug-binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:drug-binding pocket [chemical binding site]
Evidence:
  • Comment:inner one-third of the pocket is lined exclusively by non-polar side chains
  • Comment:hydrophobic pocket in the core of the beta-barrel of the capsid protein
  • Citation:PMID 7820548
  • Structure:1VBB_1, R80633 antiviral agent
    - View structure with Cn3D
  • Citation:PMID 9261087
  • Structure:1EAH_1, SCH48973 antiviral agent
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       #                                 
1VBB_1         75 IESFFa--RGACVAiievdneqp---------ttraqklfAMWRITYkd------------------------------- 112  Poliovirus ty...
YP_001497152  323 LIDLSh--IPSMVTndttdyhyfdwt---dttnkdeiigkFNFKLNS--------------------------------- 364  Seal picornav...
Q9YID8         99 VDVFHs--MAYDITtgdknpskl--------irldtttwqHTWPRQHlindvelpk-------------------afwdk 149  Echovirus 23 ...
Q9YID8        371 IAQLFsvmSDTTTPstssgi---------------ddlgyLDWSATYvpqqvihr--------------------nvvkl 415  Echovirus 23 ...
ACF95882       62 TDDFYs--CSYEVGaqgdnis------------rlvhlhtGQWSTQHgvttclrwlat---------------pgcfyta 112  DHV-1
AAC12265       45 VVQAS---VAPTMPikpdfkntd--------nflsmsyspNTAPTNPtkmvhlangtwttsqhrqslvasiqlpqafwpn 113  Clethrionomys...
AAC12265      320 LMEIA---RMPSVYkgertep-------------ggtngyFQWSHTHspinwvfd--------------------ggihl 363  Clethrionomys...
Q69014       1708 PEAIRn--CFAVFRtf-----------------------aWNDRMPTgtflgsi-----------------------slh 1739 Manchester virus
AAL79021      181 QQTISe-kLPSTVGdlviasseptqq---frgltnrwmpiNSIKVTVnskrndilaqyy------------ipedflsth 244  sacbrood virus
Q86119       1803 TSVVTaenSSASIAtagiggppqqvdqqetwrtnfyyndvFTWSVADapgsilyt---------------------vqhs 1861 Rabbit hemorr...

Feature 1                             # # #                        #                             #
1VBB_1        113 --tVQLRRKLe-FFTYSRFDMEFTFVVTanftnann--ghalnqvYQIMYIPPgaptpksw------ddytwqtSSNPSI 181  Poliovirus ty...
YP_001497152  365 ---VPNSAILanSYSFFRGPIIFHVIAAastm---------hrgrLRVCFRPNsnqey-----------sapqsMAVYYS 421  Seal picornav...
Q9YID8        150 nskPAYGQSR--YFAAVRCGFHFQVQINvnqg---------tagcALVVYEPKpivthgg-------hlefgsyTNLPHV 211  Echovirus 23 ...
Q9YID8        416 nqfSNLKPFVn-AYTYFRGSLVLRMSVYastf---------nrgrLRMGFFPNfttnt------------tsemDNAIYT 473  Echovirus 23 ...
ACF95882      113 ntqPAYGQTR--YFRFIRCGYHFRLLVNapsg---------aaggLMMVWMPYpycrvltgsynvdasvdrrslLNLPYA 181  DHV-1
AAC12265      114 eryPAWGQSR--YFAAVRCGFHIQVQLNvnig---------sagcLIAAYMPKsahdhmd-------tytfssyTNLPHV 175  Clethrionomys...
AAC12265      364 edmPNLNLFSs-CYNYWRGSTVLKLTVYastf---------nkgrLRMAFFPNhdaryt---------eeeaqnAIFMVC 424  Clethrionomys...
Q69014       1740 pniNPYTSHLsgMWAGWGGSFEVRLSISgsgv---------fagrIIASVIPPgvdps-----------sirdpGVLPHA 1799 Manchester virus
AAL79021      245 akcAPNTIPFe-TYVYGKYELEMKFVANgnkfqcgkviisvkfdsYQADNINTgfq----------------aaLSRPHI 307  sacbrood virus
Q86119       1862 pqnNPFTAVLsqMYAGWAGGMQFRFIVAgsgv---------fggrLVAAVIPPgieig-----------pglevRQFPHV 1921 Rabbit hemorr...

Feature 1                               #                                #                        
1VBB_1        182 FYTYGa-aPARISVPYVGLANAYSHFydgfakvplktdandqigdslysamtvddFGVLAVrvvndhn---ptkvtskVR 257  Poliovirus ty...
YP_001497152  422 LLDISqsnCCTLAVPFNSETWMRSTDd---------------------------vLGRLQIfvnnqlaanrtaanhvyVY 474  Seal picornav...
Q9YID8        212 LMNLAettQADLCIPYVSDTNYVKTDss--------------------------dLGRLRVyvw------------tpLT 253  Echovirus 23 ...
Q9YID8        474 ICDIGsdnSFEITIPYTFSTWMRKTNgr--------------------------pIGLFQVevlnrltynsscpnkvhCI 527  Echovirus 23 ...
ACF95882      182 ILDLRtntEIDLVIPYVNFRNYVEINatd------------------------svGGAICVfvlgafthgsgtsntvdYT 237  DHV-1
AAC12265      176 LMNAAttsQADLYIPYVHNHNYAKTDsd--------------------------dLGGIYIwcwsaltvpsgspttvdVT 229  Clethrionomys...
AAC12265      425 DIGLNn--TFEMTIPYTWGNWMRPTRgs--------------------------vIGWLRIdvlnrltynssspnavnCI 476  Clethrionomys...
Q69014       1800 FVDARitePVSFMIPDVRAVDYHRMDgaeptcslgf----------wvyqpllnpFSTTAVst-------------cwVS 1856 Manchester virus
AAL79021      308 MLDLStnnEGVLKIPFRHPRAFVRNQthktatvg--------------irpgksaSIYVQVlsplqtge--ggandmfIR 371  sacbrood virus
Q86119       1922 VIDARslePVTITMPDLRPNMYHPTGdpglvptlvl----------svynnlinpFGGSTSai--------------qVT 1977 Rabbit hemorr...

Feature 1           #               
1VBB_1        258 IYMKPK-HVRVWCPRPPR 274  Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)
YP_001497152  475 VTASLGpDAAFYCPRSGK 492  Seal picornavirus type 1
Q9YID8        254 IPSSATnDVDVTVLGSLL 271  Echovirus 23 strain CT86-6760
Q9YID8        528 VQGRLGnDARFYCPTGSL 545  Echovirus 23 strain CT86-6760
ACF95882      238 LFGEML-ETDLQCPRPFN 254  DHV-1
AAC12265      230 IFGSLL-DLDFQCPRPPG 246  Clethrionomys glareolus picornavirus
AAC12265      477 LQVKMGnDAKFMVPTTSN 494  Clethrionomys glareolus picornavirus
Q69014       1857 VETKPGgDFDFCLLRPPG 1874 Manchester virus
AAL79021      372 PFYRYT-RAEFAGMSYKV 388  sacbrood virus
Q86119       1978 VETRPSeDFEFVMIRAPS 1995 Rabbit hemorrhagic disease virus-AST89

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