1IBX,1F2R,1D4B,2EEL


Conserved Protein Domain Family
CIDE_N
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cd01615: CIDE_N 
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CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.
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Statistics
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PSSM-Id: 119367
Aligned: 38 rows
Threshold Bit Score: 97.6086
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative heterodimer interaction sites [polypeptide binding site]
Evidence:
  • Comment:Although the CAD and ICAD CIDE-N domains are structurally similar, they bind one another asymetrically using different surfaces from each protein.
  • Structure:1IBX_A; Homo sapiens DFF40 (CAD) and DFF45 (ICAD) form a heterodimer.
    - View structure with Cn3D
  • Structure:1F2R_I; the CIDE-N domain of mouse ICAD binds to the CIDE-N domain of CAD, contacts at 4 A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #        ## ##         #   #                # ##    ##                  # #
1IBX_A         4 KPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFqlp--erGSRLCLYEDGTEl-tEDYFPSVPDNAELVLLTLGQAWQG 80  human
1F2R_I        17 PLKPCLLRRNHSRDQHGVAASSLEELRSKACELLaidksltPITLVLAEDGTIvddDDYFLCLPSNTKFVALACNEKWTY 96  house mouse
NP_989616      4 PLRGFRLRRPGSAQKFGAAAGSLRGLLRKGCRLLqlp--laGSRLCLYEDGTEl-sEAFFRTLPPQTELVLLRPGESWPG 80  chicken
NP_919385      6 KPKLVKIRSANQARKYGIAAVNLKELIKKGCQLLkvs--ssGVLVCLYEDGTVv-tEEYFQNLPDNTDLVLLPHGQSWNG 82  zebrafish
CAG01759       4 KEKPVKIRSYNSSNKYGVTAKNVKELLDKGCKLLkvp--paGARICLYSDGTEf-tEKYFHTLPAHTELVLLSRGQSWSG 80  Tetraodon nigro...
NP_001120636  11 KIRCYKIRTLHSQQKYGIACKNLAELKQKACRKFqld--cpTTCVCLYEDGTEv-sEEYLETVPDNTVLLLLTPGQTWQG 87  western clawed ...
XP_417610      4 RLKPCVVRRGDGREQHGLAASSLRELRDKAGSALaigedgrPITLVLAEDGTIvddEDYFLCLPSNTKFVALAEGERWSG 83  chicken
AAH90808      19 FQKACVVSLPGSKDRHGVAAASLEELLEKACKKFsldssvePITLVLAEDGTIvedEDYFLCLPPNTKFVILTGNKKWAP 98  western clawed ...
CAG07553       4 DKKPCRVCNFTRQKSYGVAVPSLMELKTKGSEFLgfr-ssdPVTVVLEDDGTIvadESYFLCLPPNTKFMLLHEKEMWAP 82  Tetraodon nigro...
XP_001120965  11 LGNPYKIVDHTREKRKGITASSLKELISIARNRLslp-ldaEVTIVLEQDGTEvddEEYFATLERNTSLMVLYGNQKWVA 89  honey bee

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