2H3H,2QVC,3C6Q,5HQJ


Conserved Protein Domain Family
PBP1_tmGBP
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cd06314: PBP1_tmGBP 
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periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs
Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs from other bacteria. They are members of the type 1 periplasmic binding protein superfamily which consists of two domains connected by a three-stranded hinge. TmGBP is specific for glucose and its binding pocket is buried at the interface of the two domains. TmGBP also exhibits high thermostability and the highest structural similarity to E. coli glucose binding protein (ecGBP).
Links
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Statistics
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PSSM-Id: 380537
Aligned: 44 rows
Threshold Bit Score: 262.903
Created: 9-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2H3H; Thermotoga maritima glucose binding protein binds glucose, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                                                                  
2H3H_A      3 TIGVIGksv-hpYWSQVEQGVKAAGka------lGVDTKFFVPqkediNAQLQMLESFIAeGVNGIAIAp-sDPTAVIPT 74  Thermotoga maritima
CAC47775   31 EFALVFkvlnnaFSPPIQQGCEAAAkk-----lgDVTCTYLGPteydeAKQVQLAQDMVTrGVAGLGVSa-gNPKAMARI 104 Sinorhizobium meli...
NP_719254  25 KLALVPkfy-svFFDQSKNGCIDAAaq-----ieGVECIYRGPeissvRLQDQVINQLIDeGVDGIAVAvtqSKYLVENS 98  Shewanella oneiden...
ACI18918   28 VFAWIPkalnnpVFELGRDGAFKRAeelskkgpyKVEVLYVASvasdaTEQARVVEDVVArKVDGIAISc-nDPTALIDV 106 Dictyoglomus therm...
BAJ63741   34 RIAWIPkaldnpVFELGRKGAFQRAaelsatgnvKVEVIYTGSvssdaMEQARVVEDMIArKVDAIAISc-nDPIACINP 112 Anaerolinea thermo...
AEP25084   24 TILLAPkslnnpYWFAVENGMKDAAek------lGIKAIFDAPveadaAKQAEKILSYIVkGVDGIGISp-nDPEGIKVV 96  Thermotoga maritim...
KIF65803   24 RFVIVPkamnnpFFDGVRDGCMKRAke-----lgNIECIYKGPiehepATQAQIIQDFVTqKVDGLAISv-aDVAAMTKS 97  Streptomyces sp. A...
KJS82865    2 TIVIVPkaldnpIFIDAKVAAEKAGre------lGIKVDWVGStnsvaSEQVTVIEGLIAkKVDAILISc-nDATALKDV 74  Desulfosporosinus ...
SAL86189   30 VFAVVPkalgvpFYADAEKGCKEEAak------iGAECLFTGPaqlddAEQGRIVRDLITkKVAGIAIAp-nNPDSISGV 102 Burkholderia sp. L...
OYW00012   38 DFAIVPkslnnpYFDLSRDGCMAEAkk-----lgDVKCTYTGPvtqdaAAEVQTVQDLITrGIDGIAISv-aDPGSIAHV 111 Acidiphilium sp. 3...

Feature 1                   #                                                                #
2H3H_A     75 IKKALEmGIPVVTLDTDSPds-------gRYVYIGTDNYQAGYTAGLIMKell------ggkGKVVIGTGsltamnSLQR 141 Thermotoga maritima
CAC47775  105 MKMAQDkGIPVVTFDTDVLped----aglRSTYIGTDNYEFGIALAQKVLesk------kdgGTVCIQSGapasenLKAR 174 Sinorhizobium meli...
NP_719254  99 LKRAKEvGIPIVTYDSDFDasingdpknfRLAYIGTDNFELGKSLGEELKklr------pngGMLIMQSGrpdspnLNLR 172 Shewanella oneiden...
ACI18918  107 INKAVEaGIPVMTFDADSPks-------kRFTYLGVNNYEGGKWAAKLLVram------gtsGDVALLTGvpgalnLEER 173 Dictyoglomus therm...
BAJ63741  113 INQAVDaGIPVITWDSDSPqs-------kRFAYLGVNNVEGGKQAAKLLIeam------gesGKIAILTGvpgaynLEER 179 Anaerolinea thermo...
AEP25084   97 VKRALDkGIPVIMFDSDSPds-------gRYAYIGTNNYNAGYEAGKLMAqliekykaekktIRLAILTGglaalnLNER 169 Thermotoga maritim...
KIF65803   98 IDAAAAaGIPVVTFDADAPgs-------kRLAYIGTNNKDFGVALGKQLLqlr------pdgGKYAMVSGgpgatnLAER 164 Streptomyces sp. A...
KJS82865   75 INKATDrGIKIATFDSDSPds-------kRLFYIGTNNYNAGKKAAEYMTkll------pngGKVAILTGvlgapnLEER 141 Desulfosporosinus ...
SAL86189  103 ISAAMAkNIPVVTFDSDAPkt-------kRVAFIGTNNEAGGESGGEAFAkal------pkgGNYAVITGglsaanLNDR 169 Burkholderia sp. L...
OYW00012  112 IARARAaGIPVITFDADAPdt-------kRQVYVGTDNLQLGKDLGQQLVkah------ptpGTYAVISGgpaaenLAQR 178 Acidiphilium sp. 3...

Feature 1                                          #                          ##              
2H3H_A    142 IQGFKDAikds---------------eieiVDILNDEEdgARAVSLAEAALNah-pdLDAFFGVYAYNGPAQALVVKNAg 205 Thermotoga maritima
CAC47775  175 VQGIRDTlagvtkdkgaekltgqngwtepaGCPVYNNDdiTLAAQQVRDVMTnn-peLSAFVAVGGWAQYAPQAYKQAMe 253 Sinorhizobium meli...
NP_719254 173 LMGVRSAlsgkkydippgkllnneqgwtevREPLFNFDqlSQAVKQMESVMKgkpvkADSFIAVGGWAQNNDALYRDMIa 252 Shewanella oneiden...
ACI18918  174 MRGFKDEikkyp--------------kikiVTTVACYDdiNRGVQVVEETMQky-pkLRGWFFVGLWPLLAERGSMPLWe 238 Dictyoglomus therm...
BAJ63741  180 IRGFREVidqyp--------------dikvVAVRSTNDdiNLSVQVVEETMQaf-pdLNGWFFVGMWPLLAGRGSMPLWe 244 Anaerolinea thermo...
AEP25084  170 IRGFKDAledyskrs--------gkeivyvADPFPCDDdsAKAIQIIRDVTRky-tdLDGWFMSGGWPLFAPKETVISAl 240 Thermotoga maritim...
KIF65803  165 VDGVREAlkgsk-------------wvevaGSPTFCNDdpALAVQQMTDLRTat-pdLAAIVPVGGWPMFAPEGYKAFVn 230 Streptomyces sp. A...
KJS82865  142 IKGFKDAakgs---------------klqvLPVQTGEDdvAKSVEIVNQFTSan-pdLAGWWFDGGWPFFADEDALAGLk 205 Desulfosporosinus ...
SAL86189  170 IKGFKSKlgsnf--------------kevsGSPFPCNDdsSTAVQLIQDILAkn-pnIDGIFFAGGWPMFAPEAYMRALk 234 Burkholderia sp. L...
OYW00012  179 VDGVRDVlkaag-------------wkevgGSPTFCNDdsALGMQQMTDLTTan-pnLSAIVAVGGWPLFTENAYDDFYn 244 Acidiphilium sp. 3...

Feature 1                     #                   #                                           
2H3H_A    206 kv------gkVKIVCFDTtpdiLQYVKEGVIQATMGQRPYMMGYLSVTVLYlmnkigvqntlmmlpkvkvdgkvDYVIDT 279 Thermotoga maritima
CAC47775  254 plkarldskdLVVVFGDNfgpqLPLLAEGLSHYNIGQRPYDMGYETIMALDkltk---------------gekvEPFIKT 318 Sinorhizobium meli...
NP_719254 253 pfqekindkeVVIVMTDTspeqLTMLKDNLAHINVGQNPYEMGRQAILTLYkivt---------------kqqyEEVIYT 317 Shewanella oneiden...
ACI18918  239 kaa---kakkVFTVAFDTlpveLQLLKEGYLCGLVGQKYWGWGYDAIDILYrkvvn--------------nekfPDWIDS 301 Dictyoglomus therm...
BAJ63741  245 qaa---lkgnLKTVSWDTmpeeLEFLKDGYLSGLIDQNCWAWGYDTIQILYdkliy--------------gkstPDFIDA 307 Anaerolinea thermo...
AEP25084  241 ggpe--rmkdLLVVGFDTllpeLELVKAGAVKGLVGQRPYDMGYLSVLVLYnmak---------------igveNTLKML 303 Thermotoga maritim...
KIF65803  231 knkkdidagkFTLVVADTlkmqLELLRDGYSNALTGQRPFEMGEKAMETLLaikk---------------gqtaPQIIYT 295 Streptomyces sp. A...
KJS82865  206 kfr----dkgGKVVSIDTfhpmLKFMKLGYADQFIGSNYTAMGDQGVKLLLkaiqg--------------ekltETNVDT 267 Desulfosporosinus ...
SAL86189  235 nkaadlkggkFVIVSFDTlptqIKLLKDGYATTLIGQRPTKMGSESVDQLNkilk---------------gekvPPVTDT 299 Burkholderia sp. L...
OYW00012  245 khkaaidsgkLTIVSADTlpaeLSELKKGEVAALVGQQPYAMGAKAMEILRalkq---------------gkseKTIQYV 309 Acidiphilium sp. 3...

Feature 1           
2H3H_A    280 GVDVVT 285 Thermotoga maritima
CAC47775  319 GTEVCT 324 Sinorhizobium meliloti 1021
NP_719254 318 PVTFCT 323 Shewanella oneidensis MR-1
ACI18918  302 GMDIVT 307 Dictyoglomus thermophilum H-6-12
BAJ63741  308 GLRVVT 313 Anaerolinea thermophila UNI-1
AEP25084  304 PKVVKE 309 Thermotoga maritima MSB8
KIF65803  296 GLDLVT 301 Streptomyces sp. AcH 505
KJS82865  268 GFELCD 273 Desulfosporosinus sp. BIC-A1/1_c9
SAL86189  300 GVDIVN 305 Burkholderia sp. LMG 22937
OYW00012  310 GLDVVT 315 Acidiphilium sp. 37-64-53

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