1EWK,2E4U,2E4Z


Conserved Protein Domain Family
PBP1_mGluR
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cd06362: PBP1_mGluR 
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ligand binding domain of metabotropic glutamate receptors (mGluR)
Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.
Links
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Statistics
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PSSM-Id: 380585
Aligned: 25 rows
Threshold Bit Score: 494.505
Created: 18-May-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindingdimer interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1EWK; Rattus norvegicus mGuR subtype 1 complexed with glutamate, contacts at 3.5A
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  • Structure:2E4U; Rattus norvegicus mGluR subtype 2 complexed with glutamate, contacts at 3.5A
    - View structure with Cn3D
  • Structure:2E4Z; Rattus norvegicus mGluR subtype 2I complexed with 2-morpholin-4-ylethanesulfonic acid, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #                                                
1EWK_A     11 GDVIIGALFSVHhqppaekvperkCGEIREQYGIQRVEAMFHTLDKINadpvllPNITLGSEIRDSCwhsSVALEQSIEF 90   Norway rat
EEN67803   51 GEVTLGGLLSVHvngg----sgafCSVLRESGAIQRMLSMAYAVNEVNsrddllPNVTLGFAIYDDCsteTMALVETLNF 126  Florida lancelet
ESO82657    5 GDINIGAVLSIHiskn----gkscSEHIPTFRPIEYVEAVIFAISEINnrtdllPNITLGTVILDDCllpSMVLSRALQF 80   owl limpet
ELT92411   29 GDLMLGVILPVHthve----gqecGVHLRETGAVQNVEAVAYAIKKVNgddsllPGIRLGMVLLDDCatpATALGQALHF 104  Capitella teleta
ESO83931    7 GDWNIGVIIPAHefse----ksmcSRIPRRLTNLKKIEAIKFAVDEINkrkdilPNTTLGFYILDDCskdTTAMVRALQF 82   owl limpet
ESO94405   36 GDINLGALFPISsyst----tkacGDGLRSTSILQFVEALVYSVNEINnnsnilPNITLGFAILDDClkeTTTIAQSLSF 111  owl limpet
ELU18160   34 GDLNLGVLHRILirnnt--vycstSDGTVHPILLQMCEAAIFAADQINsrtdllPNITLGLTCVDSCgnsKASLARSLYL 111  Capitella teleta
ESO83929    6 IVIPIHRYDRYNi----------cSSQYREVGSFQRVQAAIFAIDEINnkttllPNIKLGYTLMDDCskdTTALARTLHF 75   owl limpet
ESO03560   57 GDIMLGVILSVNersd----sklcGPRLRDPSSVQFVEAVLFTVNEVNrkqmlpGNLKLGVVIVDDCaktETALLRALHF 132  Helobdella robusta
ELT92956    1 GDFDLGVLIPVHtrst----tdfcGLPVLNIAQLQRLEAIAFAIQELNqrnsilPNHTLGFVMFDDChsdQTALAQALHF 76   Capitella teleta

Feature 1                                                 #                    ###            
1EWK_A     91 IRdslisirdekdglnr--clpdgqtlppgrtkkPIAGVIGPGsSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTlYKY 168  Norway rat
EEN67803  127 IStegldnr------------------ctgtaypNLIGVVGAEnSGSTRMAAELLGLFHLPIISHFATSDVLNDMSlFPT 188  Florida lancelet
ESO82657   81 MPaahhfvrqettcnns---scidhahqslprfyDVIGVLGAYtSSLSIVLANVMSLYQIPQISHTSTSDLLSDKNrFPY 157  owl limpet
ELT92411  105 MPvqptsdfcrqe----------cwrskddfafyDVVGVIGAEsSQSSIMIANVLGRFEIPVVSPMSTSDLLSDKNvYPY 174  Capitella teleta
ESO83931   83 TQssklnkeq-----------------pnelssyDVIGVIGAEsSRNTVQIADLLSLFKIPVISYVSTSPLLSDKDtYPF 145  owl limpet
ESO94405  112 VPepqscqetcan-----------ntkmtstpryDVVGVVGSLkSSNSIAAASLLGPIQIPQVSYSSTSDELSNKElYPY 180  owl limpet
ELU18160  112 MEdhsqcqns----------------sdgltndqRVVGIVGPGfSRVAVAVSNFFSLFKIPVLGTFASADELSNKEnFEY 175  Capitella teleta
ESO83929   76 IQeanktrse----------------ddeglvayDVVGVIGTEsSRNSVQMADMLSIFRVPILSYLSTSPILSDKNvYPY 139  owl limpet
ESO03560  133 LPvqcasldgarslscc---cfpvpnqrkdfkffDVVGVIGAEsSSSSMAVAQLLGMIAMPQISPFASGDMLSDKRkYPY 209  Helobdella robusta
ELT92956   77 TRtplpmqpsypfypapvsnlkkcydngeslqlyDVMGVIGSEnSITTLQAANLLTSLRIPQVSYFSTSPILSNHGkYSL 156  Capitella teleta

Feature 1                                         #                                           
1EWK_A    169 FLRVVPSDtLQARAMLDIVKrynWTYVSAVHTEG-NYGESGMDAFKELAAQEg----LCIAHSDKIysna--geksFDRL 241  Norway rat
EEN67803  189 FFRTVPPDrLQAKAIIDILVyfeWTYVSLVYSDDtSYGIEGMRKLQKEAEDAsv--qICFAEIISVtal----gtdYDDV 262  Florida lancelet
ESO82657  158 FLRMLPPDkNQVKVIADLINhfnWKYVSVVYSAG-SYGEESERQLVKLFRDLd----ICVAQSLELrnnm--lklqYDDV 230  owl limpet
ELT92411  175 FMRMAPPDrYQVKGIVHLLKhfgWTYVSVVYSKG-GYGQSATEFLMQLAPEFg----LCIGSSVALsqvp--syrvLSDA 247  Capitella teleta
ESO83931  146 FSRIVPSDsLQVSVLMDIIIkfnWNYVSIVYEDG-SYGNEIYQAFKKLMNQNk----KCLAVSRVVrgel--tpdkAERI 218  owl limpet
ESO94405  181 FLRVVPPDeFQAEAIVGLIAhysWSYISIVYTEG-SYGELGYKNIKRLTDSRg----ICIGSANMVsegs--gskdYTEI 253  owl limpet
ELU18160  176 FLRMAPPDrFQAQVFVDIILsfnWTYVGLFYSEG-NYGAEGAKEIENLVRNSn----ICLAFTHRLsveskgeeeeVEQI 250  Capitella teleta
ESO83929  140 FSRIVPSDvLQAKVIVDVLAhfgWEYISVIYAEG-SYGTLGFQAVKKRIDDIg----SCLAVTTEMrqsf--sddeYDDI 212  owl limpet
ESO03560  210 FMRMSPPNqYQMRAILSLLKhfnWTYVATVYSLT-GYGESAFKEFQNLAEKNs----ICVGVSLGIvshs--dgkeLNRI 282  Helobdella robusta
ELT92956  157 FQRVVPSDdVQAEVLLQLMQafnWTFIYVVYSEG-AYGEGLYRAMERNLQDNdndrtTCFVEPFVItqdf--ddkdYEHV 233  Capitella teleta

Feature 1                                                     #                               
1EWK_A    242 LRKLRERlpkarVVVCFceg--mtVRGLLSAMRRLgvv--geFSLIGSDGWADrdeviegyEVEANGGITIKLqspeVRS 317  Norway rat
EEN67803  263 IRQLRRDrn-vkVVVMFsnf--fdANQVFAAAKRNnat--eeFVWVGSDGWGVsveeikgqEDAALGALTVVPyscpVER 337  Florida lancelet
ESO82657  231 IDSLRRFkd-arVVVLYads--ehASSLINAAKRKgay--reFIWTGSDALSLildddneyCDWNLGSLSVRPfsanLPR 305  owl limpet
ELT92411  248 INTLYKPna--rVVVLFtdq--eeTKSLFRMARKQnlc--ghFVWVGSDGLGVnlddlgeaQECAVGSLSLKSysvpVRQ 321  Capitella teleta
ESO83931  219 VKDLKSAdg-arAVVLVlit--sdAVKIFKTVKRLgcs--nhFTWLGTDGWGSnindykdvEDVALGSLTIGFhgvfVER 293  owl limpet
ESO94405  254 AKDLLDNln-arVVIVFagp--tqTKGLFTALKELglt--nyFIFIGSDAWAKrikllgdvWDVGLGAFTVSFysreDPL 328  owl limpet
ELU18160  251 AQLLDDHrs-vsVSIWFteg--pvIIRVLAGLRRAeia--inHIMLLSDSAKTdia---eyPEYIQGGMSIGFplyeVPG 322  Capitella teleta
ESO83929  213 IKSLKKApr-akAVVIFapl--aqTRALMKAVDRMnas--gdFTWIGSDAWGRniqdydgiEKAALGAITIKFyspsVKR 287  owl limpet
ESO03560  283 VTRLVNTk---vGVVLLltd-qeeTLQFLRTIKSRdli--grFTFLGGDGVGMnlddldgvEEVAVGGLSVRAyaksVPK 356  Helobdella robusta
ELT92956  234 VWTMLQEr---sANVCLviaqefeAHALIRAALQQpanrgnkMMWVAADAWARnlhslnglLPELHGMISVNFhstnVPR 310  Capitella teleta

Feature 1                                                                              #      
1EWK_A    318 FDDYFLKlrl-------dtNTRNPWFPEFWQHRFQCrlpghllenpnfkkv-------ctgnesleenyvqdsKMGFVIN 383  Norway rat
EEN67803  338 FANYLKTltv-------dkEPNNPWIGEILGNMSFSvvr-------------------------------ndnVVSPVFN 379  Florida lancelet
ESO82657  306 FSAYMKSqremrtsgensiDDLHSWLCYNSSKENSNfrnvenak---------------------dddyvpifAASYVID 364  owl limpet
ELT92411  322 FKGYFEMlh--------peRSSNPWFKHMWSDLFQCswvderhneslpicd-------atqkitesphyssevQVSTLID 386  Capitella teleta
ESO83931  294 LDNHIKHltp-------anATYNPWFDAFFERNFDCkfgpignetkcdr------------wknlsegyapsfMPGFVMD 354  owl limpet
ESO94405  329 YTDYFKTirp-------eaDVRNPWFREFWGKHFKCsfdsvispcnvdd------------vlsfengfkaisTVTPVMD 389  owl limpet
ELU18160  323 LRNHLASlqp-------gvNTHNPWIQKAWDTLCEYdnctleeiv--------------------ksmfdnvqYGMPYYE 375  Capitella teleta
ESO83929  288 FDDSFMHlsv-------ksAPENPWIKHFVEAHNNCkfdatgntaacnd------------tmnfvpnykqevTVSLVMD 348  owl limpet
ESO03560  357 FLDYFESltp-------csPHSNPWLRQMWQDLNQQqqqdkqqnyqqqhqqqpqpnlncnktinetydysrekPLSITMD 429  Helobdella robusta
ELT92956  311 FDQHFQNina-------slPSKNPWLREYWKQFFNCtvfnneseaclpd-----------lklsnhptyvadnSVSLVFD 372  Capitella teleta

Feature 1                                                                                     
1EWK_A    384 AIYAMAHGLQNMHHALCpghvglc--------------------------damkpidGRKLLDFLIKSSFvgvsgeEVWF 437  Norway rat
EEN67803  380 AVNMFAHALDDMLRTGCpgvptgcni-----------------------tggltcdfLKTLTEHIRNVSFvge-cgFELK 435  Florida lancelet
ESO82657  365 AVYAFAYALDTYIKKYCqgvfgke---------------------------lrhcvnGETLLGILKDVTFngs-igEISF 416  owl limpet
ELT92411  387 TVSVYASALDRVIRKNCpgvtgtsar----------------------dcvtgkrllGDLYKTELAGLSG------NISF 438  Capitella teleta
ESO83931  355 AVYAFAYSLEKSLQNCKdadik-------------------------------dcikGRRFLNVIRNTSFegd-ngMVGF 402  owl limpet
ESO94405  390 AVSTFAKAIDSLLKDNCpladsat---------------------------ardcisGPLLLEYLKNTTFsgr-ngLIRF 441  owl limpet
ELU18160  376 AVYVYADALHKLITKRCpeafeeve-------------------------yladcidGEELLETMKKCELemi-sgPIEF 429  Capitella teleta
ESO83929  349 AVYAYALAMNKTLSECPtgstsp-----------------------------rlcfnGSDLVEALRSVTFnge-hgKVAF 398  owl limpet
ESO03560  430 TVYVFVDAIKRLISNSCsdlahfgqfhvrnnfpnlghlsshddasvnrtshndniesSITNNNYLLNTSIign-ngEIRF 508  Helobdella robusta
ELT92956  373 AVKTFALALHNQVKVHChglple----------------------------itkccvKDGLGEALRSVSFvgeandFVEF 424  Capitella teleta

Feature 1                                                     
1EWK_A    438 DEKGDAPGRYDIMNLqytea--nrydYVHVGTWhe------gVLNIDD 477  Norway rat
EEN67803  436 FHHGEVVGRYALQNLqrrtd--gtyeYVRVGMW---------DIDDDD 472  Florida lancelet
ESO82657  417 DENGDVVGKYEIRQCqsky---gvprHEEVGIWdmk----tgMLSLKQ 457  owl limpet
ELT92411  439 DERGDIKGRYEVVNFrrass--rayeTKGVGIWdea----sqQLSINI 480  Capitella teleta
ESO83931  403 DEFGDGKSTYAIRTLretn---ggyqLAVIGVWdtgkrlftyFNTKNI 447  owl limpet
ESO94405  442 DANGNALGSYIIDQLitgs----pyaQGRVATYdaf----tkQLTMDG 481  owl limpet
ELU18160  430 DENGDRIGQYHLYHYrsndg-gasveTEFLAVWd-------qRNFLNF 469  Capitella teleta
ESO83929  399 NSEGDGVAVYELQNFqlvn---geyvLRPIGLWds-----evKNFTTF 438  owl limpet
ESO03560  509 DNNGDIRGRYEIVNFqknssrrngymSQRVAVWhla----nqTLDIDD 552  Helobdella robusta
ELT92956  425 FDNGDGMISYQISNMqrdntsaigykLQVVGLWdky----tqLLDVDL 468  Capitella teleta

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