5X2M,5X2M


Conserved Protein Domain Family
PBP1_taste_receptor

?
cd06363: PBP1_taste_receptor 
Click on image for an interactive view with Cn3D
ligand-binding domain of the T1R taste receptor
Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.
Statistics
?
PSSM-Id: 380586
Aligned: 13 rows
Threshold Bit Score: 566.936
Created: 29-May-2007
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ligand bindingdimer interface
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:5X2M; ligand-binding domain of the Oryzias latipes taste receptor in complex with L-glutamine, contacts at 4A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
5X2M_A         9 FHLRGDYLIGGLFNihyvaaanfqrp----------------qaidcssklfilPNYRRFQMMRFSVEEINns---ssLL 69   Japanese medaka
5X2M_B        13 FSMPGDIKLGGLFPikeqsnevsndlt---------------klnsvscdslnkDGLGRALVMKYAVEEINan---sqLL 74   Japanese medaka
CAG03199      28 FRLEGDYLLGGLFEihydtfptphdrp---------------esldcssktlflSNYRRFQLMRFAVAEINns---tdLL 89   Tetraodon nigr...
Q7RTX1        32 FTLPGDYLLAGLFPlhsgclqvrhrpe---------------vtlcdrscsfneHGYHLFQAMRLGVEEINns---taLL 93   human
Q7RTX0        29 LRMKGDYVLGGLFPlgeaeeaglrsrt---------------rpsspvctrfssNGLLWALAMKMAVEEINnk---sdLL 90   human
NP_001034717  38 FKSPGDILIGGLFPinqltselsqrv----------------kpddlqcdsistYGLSLSLVMKFTVDEINsk---khIL 98   zebrafish
NP_001034920  28 FSLEGDFLLGGLFPlheidqvtpvftp---------------ettecfrytaspSGFQMLQVMRFAVEEINns---stLL 89   zebrafish
Q8TE23        27 FYLPGDYLLGGLFSlhanmkgivhlnf--------------lqvpmckeyevkvIGYNLMQAMRFAVEEINnd---ssLL 89   human
NP_001072097  32 FNLPGDIKLGGLFPlnrltsnlsqrt----------------epdqiscdrintYGLGMAIAMKYTVDEINan---qiLL 92   torafugu
NP_001034614  22 LHLQGDYILSGWFAlhnsdstipptp----------------ylndckkgltnkHGYHLVQAFRYAVDEINngtqdkqLL 85   zebrafish
AIL54463      22 FRSPGEFRLAGLFQihalrpgrpla------------------hgcgvaaafrsHGYHLSQMMRFAVEEINns---saLL 80   chicken
KPP64665     144 FNVPVFWPILVMYFimlfcitmkrqikhmikyryipfthgkrtyrgkedtgktfARYQQLQVFRFTIEEINns---tdLL 220  Asian bonytongue
OPJ86078      26 FRKPGDYILGGLFPfgmdagnltars----------------eptlvvcerlfaEGLIWALGMKFAIDQINns---tsLL 86   Patagioenas fa...
Feature 1                                                              #                      ###
5X2M_A        70 PNVSLGYQMFDHCs-dIHSFPGIFKLLSvndl--irpwEDASTGLPNAIGVVGPFtstHALSIAPIFMTNLFPMVSYGCS 146  Japanese medaka
5X2M_B        75 PGVKLGYKIYNTCrhsAVIVRPALSFLTeksngtlsveCNYTDYETDMVAVIGPQsseMVTVIGKLLGFFLMPQISFGAT 154  Japanese medaka
CAG03199      90 PNVTLGYEVFDHCs-dTRCFAGIFKLLSvdnv--vqpwNVPGKKVSKVVAVVGLFtstFTLTVAPLFMMDFIPMISYGSS 166  Tetraodon nigr...
Q7RTX1        94 PNITLGYQLYDVCs-dSANVYATLRVLSlpgqhhielqGDLLHYSPTVLAVIGPDstnRAATTAALLSPFLVPMISYAAS 172  human
Q7RTX0        91 PGLRLGYDLFDTCsepVVAMKPSLMFLAkagsrdiaayCNYTQYQPRVLAVIGPHsseLAMVTGKFFSFFLMPQVSYGAS 170  human
NP_001034717  99 PGITLGFESYDTCmqpAVIMKPVLQLLTqestdeldiyCNYTNYKPRVMAIIGPDssdVVPDAGKLIGFFLMPMISYGAT 178  zebrafish
NP_001034920  90 PNVSLGYELFDHCs-nTRNFGSLLSFISkngs--ikpnVKRINYQSDVIALTGPYgstRTISIAPLITMDLIPLVNYGAS 166  zebrafish
Q8TE23        90 PGVLLGYEIVDVCy-iSNNVQPVLYFLAhednl-lpiqEDYSNYISRVVAVIGPDnseSVMTVANFLSLFLLPQITYSAI 167  human
NP_001072097  93 PGIQLGYEIYDTClqsAIIVRPTLSLLSakhdntfsvqCNYTNYETSISAVIGPNnseMVSVIGKLLGFFLMPQISYGAT 172  torafugu
NP_001034614  86 PGVTLGYRTYDICs-lPASNLATLDLLAq--------qLHPSAVDSRAVAIIGPDsssYAFTPAAALGVFLVPQISYEAT 156  zebrafish
AIL54463      81 PNVTLGYEIHDTCt-eAANLHGTLRALGregrhdvevlSAPQRYEPRAVAVIGPDstqLALTTAAILGVFLVPEISYEAS 159  chicken
KPP64665     221 PGVILGYEIFDYCt-dSLNFRAALDFLSsk------gvVPFINIPRKVISVTGPFgsqKTLTVAPLFMANLMPMVNHGAS 293  Asian bonytongue
OPJ86078      87 PGVTLGYDMWDTCsepLVALQPALLFLTqngtagigvlCNYTDYQPRVTAVIGPHssdLCLVTAKLFSSFLIPQVSYGAS 166  Patagioenas fa...
Feature 1                                                       #                                
5X2M_A       147 GSVFSkenlYPSFLRTVHSNkDVINAIVGIILnFNWRWVAFLYSDDdFGKDGLEQFKNKIEDSeICLAFYKAInvn---- 222  Japanese medaka
5X2M_B       155 SDKFSdslvYPSFFRTVPSDiRQVDAMVQLIKkFNWNWVAVVGSEEeYGQQGVQQFSKKAEDMgVCVAYQGLIpiydd-- 232  Japanese medaka
CAG03199     167 SSILSekvkFPSFLRTVHSSqEVIQVIVKLLQyFKWHWVAFLYSNDdYGANAQKLFIEKIKNTdICLAYTHDLvs----- 241  Tetraodon nigr...
Q7RTX1       173 SETLSvkrqYPSFLRTIPNDkYQVETMVLLLQkFGWTWISLVGSSDdYGQLGVQALENQATGQgICIAFKDIMpfsaq-- 250  human
Q7RTX0       171 MELLSaretFPSFFRTVPSDrVQLTAAAELLQeFGWNWVAALGSDDeYGRQGLSIFSALAAARgICIAHEGLVplprad- 249  human
NP_001034717 179 SDEFSnkqtYPSFMRTVASDqWQVVAMIQLLKqFGWNWVSVIGSDEeYGQMGQQQFSSMANDEsICVAYQGLIpvysd-- 256  zebrafish
NP_001034920 167 SSVLSnklqYPSFVRTVPSNkDMINMIIHMIRwFGWNWVAFLGSKDaYSTDGLNLFNTYINNTgICVAYQERLnld---- 242  zebrafish
Q8TE23       168 SDELRdkvrFPALLRTTPSAdHHIEAMVQLMLhFRWNWIIVLVSSDtYGRDNGQLLGERVARRdICIAFQETLptlqpnq 247  human
NP_001072097 173 SEKFSdtalYPSFFRTVPSDkWQVEAMVLLLEeFNWNWVAVVGSDEeYGQRGVQDFSKLAANKsICVAYQGLIpvytd-- 250  torafugu
NP_001034614 157 NELLSnkllYPSFFRTIPSDkNQVNAMIQVLVkFNWTWIALLGSDNsYGIQGMQSLSEQAPLNnICIAYQAQIpavtd-- 234  zebrafish
AIL54463     160 LEMLStkrfYPSFLRTIPSDgQQVKAIGLLLQrFGWTWVALVGSDNtYGRDGLNALSELLAATdVCVAYRGVIpttkd-- 237  chicken
KPP64665     294 SVELSnkylYPSFFRTIPSDyYQVRAIVRILQyFNWNWIAFFGSDNaYSQDALTVFMDELKTAnICLAFNGILsgd---- 369  Asian bonytongue
OPJ86078     167 SERLGntesFPSFYRTVPSDtSLVEAVVLLLNeFGWNWVGSIGSDNeYGRGAQGLFVSVAGNHnICVAFEGLIptdlad- 245  Patagioenas fa...
Feature 1                                                               #                        
5X2M_A       223 -------tdYLQVFKQIEEQnikVIVVFapkvyAEAVVESAVQLnvtnKVWIADDGWslnkklpsMNGIQNIGTVLGVAQ 295  Japanese medaka
5X2M_B       233 -----pkpaIQTIINNIQTTevkVVVVFslvspAVSFFEEVIKKnl-tGVWIASSSWaisdkvysLPNIDSIGTVIGFID 306  Japanese medaka
CAG03199     242 -------sdFLSIFQWIKSQkivVIVVMapewsAKPLVKSAIQHnvtdKVWIAGEAWslnk-elpKEKGIKHIGTVIGVA 313  Tetraodon nigr...
Q7RTX1       251 ----vgderMQCLMRHLAQAgatVVVVFssrqlARVFFESVVLTnltgKVWVASEAWalsrhitgVPGIQRIGMVLGVAI 326  human
Q7RTX0       250 ---dsrlgkVQDVLHQVNQSsvqVVLLFasvhaAHALFNYSISSrlspKVWVASEAWltsdlvmgLPGMAQMGTVLGFLQ 326  human
NP_001034717 257 -----pgptIQDMLNRIVDAkvgVVVVFsipipAKAFFTEVIKRni-tAVWVASTAWslndgvstLPGISSIGTVLAFAD 330  zebrafish
NP_001034920 243 -------anYSQTLKKIDMLninVIVVFavpqyAVNIINTAIADnirdKVWIASETWsmnqqlprEPGVEKIGTVIGITD 315  zebrafish
Q8TE23       248 nmtseerqrLVTIVDKLQQStarVVVVFspdltLYHFFNEVLRQnftgAVWIASESWaidpvlhnLTELRHLGTFLGITI 327  human
NP_001072097 251 -----pepmVKTILSNINSTkarVVIVFslsnqAEIFFKEVIRMkl-kGVWIGSTSWtindavtsLPDIQTGWTILGFVE 324  torafugu
NP_001034614 235 ----stkkyMQDMVKNILKTkvnTIVVFankrrAAGFFPFVIAQnvtgKVWIGTEDWsvastvssIPGISMIGTVIGVAV 310  zebrafish
AIL54463     238 ----agspeLRKLIQTLVDSrvnVTVVFsnrrnAQPFFEAVVQEnitgMVWVGSEDWslaqtiwqVPGIQNIGSVIGISV 313  chicken
KPP64665     370 ------tskYFDMFDKLNILninVVVVFaniefVIPFIEKAIEKrv-rKVWIASETWslnqdlmnADGIEALGVIIGMSI 442  Asian bonytongue
OPJ86078     246 ---pnaqkqLEDTIKTINKTkvnIIVLFtfsqaAQALLEHSIRMglseKVWIGTETWllsdiptsIPNIQSIGTVLGFIM 322  Patagioenas fa...
Feature 1                                                                                        
5X2M_A       296 pv---vtIPGFTDFIYSaisqtdggdteqkmfcnq--------------kcncsnlsvksllnadpsFSFPVYAAVYAIA 358  Japanese medaka
5X2M_B       307 et---etLELLSPFTEVlfkkiheasptekpedpynpc--------pecwslspanvslvkeesvqrTAFSVYAAVYTVA 375  Japanese medaka
CAG03199     314 qly--lnIPRFQDFIYSvkkqnecesaeqqfcnrv---------------ckcsnvsaedtlavdpsYAFSVYSAVYAAA 376  Tetraodon nigr...
Q7RTX1       327 qk---raVPGLKAFEEAyaradkkaprpchkgswcssnq------lcrecqafmahtmpklkafsmsSAYNAYRAVYAVA 397  human
Q7RTX0       327 rg---aqLHEFPQYVKThlalatdpafcsalgereqgleed--vvgqrcpqcdcitlqnvsaglnhhQTFSVYAAVYSVA 401  human
NP_001034717 331 it---rpLDLFTPYIRElftkiegmaipqqpdadispldn----pcprcsyvsqanvsmvevdlvqrSAFSVYAAVYCAA 403  zebrafish
NP_001034920 316 rl---ltLPGFNEFILKdmgtanvnaskfqtntcnq------------kcdycpsltaediinenpsFSFAIYAAMYTIA 380  zebrafish
Q8TE23       328 qs---vpIPGFSEFREWgpqagppplsrtsqsytcnqe--------cdnclnatlsfntilrlsgerVVYSVYSAVYAVA 396  human
NP_001072097 325 qt---qsVDLLRAYTYAllnklseerahtrssaqnsnypsn---pcpqcwnlspanislvtdlviqrKAFSVYAAIYSVA 398  torafugu
NP_001034614 311 ky---teFDGFDNYERLsvpglknpgqfnlsvpcmqn-----------tnlydiaingfslsqyditSSFNVYKAVYAVA 376  zebrafish
AIL54463     314 eqaeptmLKRLESWENAreravsgsagstgvgggngasssdgiqlnctqhcpgchlladtpdiydiqASYNVYSAVYAVA 393  chicken
KPP64665     443 qgq--gtLLGLDNFIINtmhqqndtkcpsgsqvkktcn---------qvcfeclktnpeiithqdptFNFAIYSAVYAVA 511  Asian bonytongue
OPJ86078     323 ka---gtVPGFQKYVADlftsvqqdefcqesrkssrlvapd--gtdthceqcdhvsladvssalshsRIQPVYAAVYSVA 397  Patagioenas fa...
Feature 1                                                                                        
5X2M_A       359 HALHNTLRCgsdRCPKNit---vhPHMILEELKKS--------------------------------------------- 390  Japanese medaka
5X2M_B       376 HALHKLLECnsaACKWSsst-rlyPWKLLEVLKEF--------------------------------------------- 409  Japanese medaka
CAG03199     377 HALHNVLNCgtgKCDSGvs---vsPPALLAELKRS--------------------------------------------- 408  Tetraodon nigr...
Q7RTX1       398 HGLHQLLGCasgACSRGrv----yPWQLLEQIHKV--------------------------------------------- 428  human
Q7RTX0       402 QALHNTLQCnasGCPAQdp---vkPWQLLENMYNL--------------------------------------------- 433  human
NP_001034717 404 YALHDLLGCnatSCTRNpkrdnvyPWQLLRKLQKL--------------------------------------------- 438  zebrafish
NP_001034920 381 HALHKVLQCdtkGCPKNtp---fePYMLLGEMKKL--------------------------------------------- 412  zebrafish
Q8TE23       397 HALHSLLGCdksTCTKRvv----yPWQLLEEIWKV--------------------------------------------- 427  human
NP_001072097 399 QALHNFLQCnstACKNTsev-kiyPWKLLKTLRHT--------------------------------------------- 432  torafugu
NP_001034614 377 HALHNVLDCdsgLCQKYdv----qPWQVYEQLRQV--------------------------------------------- 407  zebrafish
AIL54463     394 HGLHNLLGCasgVCSKGrv----yPWQLLQKIKQV--------------------------------------------- 424  chicken
KPP64665     512 HALHKVLECgssSCNNSrp---flPYVLTNALKGI--------------------------------------------- 543  Asian bonytongue
OPJ86078     398 AALHRALGCarpPCPRApi----rPWQVRKDQGKKqqflaqslrsahiplcrapanrawnnraednrarrllaaildhll 473  Patagioenas fa...
Feature 1                                                                                 
5X2M_A       391 ------NFTLLNQTVQFDENGDPKFGSLSVVFWNSSGn--AEEVGSYHfqssiHLSINK-TKIKWFTNGEVPT 454  Japanese medaka
5X2M_B       410 ------SVNISNTSLKFDQNGNPNIGYSVIQRIWENQs--LSSVGSYRs---aNLSINE-TLFKWYTNNSEKP 470  Japanese medaka
CAG03199     409 ------NFTLLNQTIHFNEDGDPLFGSYAVHFWNRSGa--AENFGICSfypsiQIFINE-SKIQWHSKEVPVS 472  Tetraodon nigroviridis
Q7RTX1       429 ------HFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPkwtFTVLGSSTws-pvQLNINE-TKIQWHGKDNQVP 493  human
Q7RTX0       434 ------TFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSvprLHDVGRFNg----SLRTER-LKIRWHTSDNQKP 495  human
NP_001034717 439 ------SLDLEGVNIQFDDEGNPNFGYDFMQWIFNDTtvtFDVIGYFYq----NLTIES-NAIKWHTKNGEVP 500  zebrafish
NP_001034920 413 ------DFPLNGRQVKYDKNYDPPISYAVVLWHTDENspqFEMVGTYDtypktVFTIDN-SRFPWRNDSIPFS 478  zebrafish
Q8TE23       428 ------NFTLLDHQIFFDPQGDVALHLEIVQWQWDRS---QNPFQSVAsyyplQRQLKNiQDISWHTINNTIP 491  human
NP_001072097 433 ------KVDINGTMLEFDSNGNPNVGYNLIELIWKNStleFVEVGSFNk----ILNINV-SLFKWHTETSEVP 494  torafugu
NP_001034614 408 ------RFSIRNASFYFDKNGDPPTGYDIVTWEWTNGlwsFKVVGNYSpg-anDLHLDD-SQIDWSGQVSPVT 472  zebrafish
AIL54463     425 ------NFSLHKSYISFDANGNIRKGYNIIAWNWRGQswaFDVVGAFTvn-pnRLHIDQ-SKILWHTKDHQVP 489  chicken
KPP64665     544 ------SFTLYNETMVFDESGNPPARYTIVYWDWNSRn--FVKIGSYYtdpevHFILNE-ELINWQGNKSAPV 607  Asian bonytongue
OPJ86078     474 hfmnsfPFEVNGQRFRFDQSHSINTGYKLIFWSWKNStltYQPVGDYGd----SLYINK-SQIQFHTADQKEP 541  Patagioenas fasciata ...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap