Conserved Protein Domain Family
ALDH_F2BC
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cd07142: ALDH_F2BC 
Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like
Included in this CD is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial homotetramers that oxidize acetaldehyde and glycolaldehyde, but not L-lactaldehyde. Also in this group, is the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde.
Links
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Statistics
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PSSM-Id: 143460
Aligned: 7 rows
Threshold Bit Score: 900.706
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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NAD(P) bindingcatalytic
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q8S528        51 VEHTQLLIGGRFVDAVSGKTFpTLDPRNGEVIAQVSEGDaeDVNRAVAAARKAFDEGPWPKMTAYERSKILFRFADLIEK 130 thale cress
ABK24267      61 VKHTQLLIDGQFVNAASGKTFpTFDPRTGDVIANVAEGDapDVNRAVKAARKAFDVGPWPKMTAYERSCIMLRFADLLEK 140 Sitka spruce
Q9SU63        55 VSHTQLLINGNFVDSASGKTFpTLDPRTGEVIAHVAEGDaeDINRAVKAARTAFDEGPWPKMSAYERSRVLLRFADLVEK 134 thale cress
XP_001767457  22 VQYTKLFINNSFVDSVSGKTFpSIDPRSEEVAVEVAQAAaeDVDRAVKAARKAFEEGPWPRMPGCERAGIMNRIADLLDE 101 Physcomitrella ...
CAD10505      41 NLPNKLFINNKWVDAKSGKTMgVEDPRNGEEILRVAEGDsaDVDLAVKAARKAFDEGAWPRMTGKERGRLIYKLADALEA 120 Polytomella sp....
Q56YU0        17 IKFTKLFINGQFIDAASGKTFeTIDPRNGEVIATIAEGDkeDVDLAVNAARYAFDHGPWPRMTGFERAKLINKFADLIEE 96  thale cress
XP_001785650  47 VKLTKLLIDGEFVDAASGKTFpTIDPRSEQVIAHVAEGDveDVNRAVRAARKAFDHGPWPKMPPFQRQRILLKYADLLDQ 126 Physcomitrella ...

Feature 1                                                                             ## ##      
Q8S528       131 HNDEIAALETWDNGKpyeqSAQIEVPMLARVFRYYAGWadk-ihGMTMPgd-gpHHVQTLHEPIGVAGQIIPWNFPLLML 208 thale cress
ABK24267     141 HNDEIAALETWDNGKpyeqASLVEVPMAVRLFRYYAGWadk-ihGLTVPad-gpYHVQTLHEPIGVAGQIIPWNFPLLMF 218 Sitka spruce
Q9SU63       135 HSEELASLETWDNGKpyqqSLTAEIPMFARLFRYYAGWadk-ihGLTIPad-gnYQVHTLHEPIGVAGQIIPWNFPLLMF 212 thale cress
XP_001767457 102 HKDELSALDTLNMGKvydmARLGEAPLAIGLFRYYAGRwcdkaqGMTLPtn-gpFHAYTLHEPIGVVGSILPWNAPFYLL 180 Physcomitrella ...
CAD10505     121 NAEAFARLETLDNGKplniSRIADVPLSVDHFRYYAGWadk-ihGKTIPvd-gpHMAYTLHEPLGVVGAIIPWNFPLLMA 198 Polytomella sp....
Q56YU0        97 NIEELAKLDAVDGGKlfqlGKYADIPATAGHFRYNAGAadk-ihGETLKmtrqsLFGYTLKEPIGVVGNIIPWNFPSIMF 175 thale cress
XP_001785650 127 HADELAALETMDSGKpyeqARYAELPLMSRQFRYFAGWadk-ifGTTGPsd-giHAVQTLHEPIGVVGQIIPWNFPLVMY 204 Physcomitrella ...

Feature 1                        #  #                            ##   ##            ####  #  ##  
Q8S528       209 SWKLGPALACGNTVVLKTAEQTPLSALLVGKLLHEAGLPDGVVNIVSGFGataGAAIASHMdVDKVAFTGSTDVGKIILE 288 thale cress
ABK24267     219 AWKVGPALACGNSIVLKSAEQTPLTALYAAKLFHEAGLPPGVLNIVSGFGptaGAAIARHMdIDKVAFTGSTETGKAVLE 298 Sitka spruce
Q9SU63       213 AWKVGPALACGNTIVLKTAEQTPLTAFYAGKLFLEAGLPPGVLNIVSGFGataGAALASHMdVDKLAFTGSTDTGKVILG 292 thale cress
XP_001767457 181 AMKVAPALACGNTIVLKPAQQSPLSALLIAKLAAEAGLPDGVLNVVTGYGd-tGMHIASHMdVDKVAFTGSTQVGRQIMQ 259 Physcomitrella ...
CAD10505     199 AWKLGPALAAGNTIVLKPAEQTPLSALLIAKLAAEVGFPEGVINVVTGFGptvGGPLASHKlVDKTAFTGSTEVGKIVAR 278 Polytomella sp....
Q56YU0       176 ATKVAPAMAAGCTMVVKPAEQTSLSALFYAHLSKEAGIPDGVLNIVTGFGstaGAAIASHMdVDKVSFTGSTDVGRKIMQ 255 thale cress
XP_001785650 205 CWKVAPALAAGNTIVLKTAEQTPLSAILAGKLALEAGIPPGVLNIVSGYGptaGASIAEHMdIDKVAFTGSTEVGKLVMA 284 Physcomitrella ...

Feature 1                    ###                               #                                 
Q8S528       289 LASksnLKAVTLELGGKSPFIVCEDADVDQAVELAHFALFFNqGQCCCAGSRTFVHErVYDEFVEKAKARALKRnVGDPF 368 thale cress
ABK24267     299 LASksnLKPVTLELGGKSPFIVCEDADVDQAVELAHFALFFNqGQCCCAGSRTFVHEsIHDEFVEKAKARCLSRvVGDPF 378 Sitka spruce
Q9SU63       293 LAAnsnLKPVTLELGGKSPFIVFEDADIDKAVELAHFALFFNqGQCCCAGSRTFVHEkVYDEFVEKSKARALKRvVGDPF 372 thale cress
XP_001767457 260 AAAqsnLKPVNLELGGKSPFIIFGDADMDAAVESAHQAIFYNqGQMCVAGSRTFVHEsVYDEYLERAKARAEKRvVGDPF 339 Physcomitrella ...
CAD10505     279 LAAe-qIKPCTLELGGKSPIIVCPDVDVDRAVADAHMALFFNhGQCCAAGSRVYVHEkIYDEFVEKATKAAANHsVGDPF 357 Polytomella sp....
Q56YU0       256 AAAasnLKKVSLELGGKSPLLIFNDADIDKAADLALLGCFYNkGEICVASSRVFVQEgIYDKVVEKLVEKAKDWtVGDPF 335 thale cress
XP_001785650 285 AAArsnLKPVTLELGGKSPMIICEDANVDEAVELAHFALFFNmGQCCCAGSRTFVHEsIYDEFVEKSKARALKRvVGDPF 364 Physcomitrella ...

Feature 1                                                                        # #             
Q8S528       369 ksgiEQGPQVDSEQFNKILKYIKHgv-eaGATLQAGGDRLGSKGYYIQPTVFSDVkdDMLIATDEIFGPVQTILKFKdLD 447 thale cress
ABK24267     379 rkgvEQGPQIDQEQFNKILRYIKAgk-esGAKLVTGGDQIGTKGFYIMPTIFSEVqdDMAIATDEIFGPVQSIIKFKtLD 457 Sitka spruce
Q9SU63       373 rkgiEQGPQIDLKQFEKVMKYIKSgi-esNATLECGGDQIGDKGYFIQPTVFSNVkdDMLIAQDEIFGPVQSILKFSdVD 451 thale cress
XP_001767457 340 kpgvEQGPQQADEAQFNKVMSYIRagkdeGARLITGGERVGSKGYYIQPTIFSDVqdDMKICREEIFGPVMSVIKFKtVE 419 Physcomitrella ...
CAD10505     358 sgqyDQGPQVDNAQFSKILSYVEHgk-aeGAKLNVGGCRVGNKGYYVAPTVFSNVtdNMKIAREEIFGPVQSILKYStFD 436 Polytomella sp....
Q56YU0       336 dstaRQGPQVDKRQFEKILSYIEHgk-neGATLLTGGKAIGDKGYFIQPTIFADVteDMKIYQDEIFGPVMSLMKFKtVE 414 thale cress
XP_001785650 365 rkgvEQGPQVDKDQFHKVLGYVESgm-eqGANLITGGGRLGSKGYYIKPTIFTDVkeGMKIFDEEIFGPVQSIAKFKtLD 443 Physcomitrella ...

Feature 1                    #                                     #                            
Q8S528       448 EVIARANNSRYGLAAGVFTQNLDTAHRLMRaLRVGTVWINCFdVLDASIPFGGYKMSGIGREKGIYSLNNYLQVKAVVT 526 thale cress
ABK24267     458 EVIKRANASRYGLAAGVFTQNIETANTLTRaLRVGTVWVNCFdIFDAGIPFGGYKMSGTGREKGIYSLQNYLQVKAVVT 536 Sitka spruce
Q9SU63       452 EVIKRANETKYGLAAGVFTKNLDTANRVSRaLKAGTVWVNCFdVFDAAIPFGGYKMSGNGREKGIYSLNNYLQIKAVVT 530 thale cress
XP_001767457 420 EVIQRSNQSEYGLGATVMSKNVDIINTVTRsLKAGIVWVNTYgILTPSAPFGGYKSSGFGRENGAYALANYQQVKSVIM 498 Physcomitrella p...
CAD10505     437 EVIRRANASDYGLASGVFSKDLDTVNTLVRgLHAGTVWVNCYnLFDSAVPFGGFKTSGIGREKGEYALSNYTKVKAVYM 515 Polytomella sp. ...
Q56YU0       415 EGIKCANNTKYGLAAGILSQDIDLINTVSRsIKAGIIWVNCYfGFDLDCPYGGYKMSGNCRESGMDALDNYLQTKSVVM 493 thale cress
XP_001785650 444 EVVQRANNTVYGLAAGIFSNNINTVNTLSRaLRAGTIWVNCFdVFDATIPFGGYKQSGIGREKGKYVLESYTQVKAVVT 522 Physcomitrella p...

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