1SQI,1SP9,3ISQ,1T47,2R5V,1CJX,3ZGJ,5EC3,1SQD,5CTO,1SP8


Conserved Protein Domain Family
HPPD_C_like

?
cd07250: HPPD_C_like 
Click on image for an interactive view with Cn3D
C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate synthase (HmaS)
HppD and HmaS are non-heme iron-dependent dioxygenases, which modify a common substrate, 4-hydroxyphenylpyruvate (HPP), but yield different products. HPPD catalyzes the second reaction in tyrosine catabolism, the conversion of 4-hydroxyphenylpyruvate to homogentisate (2,5-dihydroxyphenylacetic acid, HG). HmaS converts HPP to 4-hydroxymandelate, a committed step in the formation of hydroxyphenylglycerine, a structural component of nonproteinogenic macrocyclic peptide antibiotics, such as vancomycin. If the emphasis is on catalytic chemistry, HPPD and HmaS are classified as members of a large family of alpha-keto acid dependent mononuclear non-heme iron oxygenases most of which require Fe(II), molecular oxygen, and an alpha-keto acid (typically alpha-ketoglutarate) to either oxygenate or oxidize a third substrate. Both enzymes are exceptions in that they require two, instead of three, substrates, do not use alpha-ketoglutarate, and incorporate both atoms of dioxygen into the aromatic product. Both HPPD and HmaS exhibit duplicate beta barrel topology in their N- and C-terminal domains which share sequence similarity, suggestive of a gene duplication. Each protein has only one catalytic site located in at the C-terminal domain. This HPPD_C_like domain represents the C-terminal domain.
Statistics
?
PSSM-Id: 319913
Aligned: 52 rows
Threshold Bit Score: 198.163
Created: 17-Feb-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
active siteFe binding site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1SQI_A; active site of Rattus norvegicus 4- hydroxyphenylpyruvate dioxygenases bound to Fe(II) and inhibitor NTBC defined by 3.5 A contacts.
    View structure with Cn3D
  • Structure:2R5V_A; active site of hydroxymandelate synthase from Amycolatopsis orientalis, by 4A distance.
    View structure with Cn3D
  • Structure:1T47_A; active site of (4-hydroxyphenyl)pyruvate, by 4A distance.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                                         #
1SQI_A       178 LEIIDHIVGNQPdqEMESASEWYLKNlQFHRFWSVddtqv-------------------------------hteysSLRS 226 Norway rat
XP_002610463 186 LSHFDHVTYACPmsSSPPILEWYERClGLKRFLVNrdesedqg-------------------------fivqgadvGMRL 240 Florida lancelet
XP_002114442 156 VTHIDHVTCICHqnTTVPLLNWYQKCfNFSRFTINadeeedg----------------------------ytlndlHIKM 207 Trichoplax adha...
XP_002120769 168 MTAVDHIAFALKleHTDEVVQWYNHClGFSRMIINieedfddg-------------------------fvvkegtrGLRL 222 Ciona intestinalis
EFA85545     468 SIHMDHVATCVKngQLEKCIDWYSRCmGFNLLEVEagknkkedsrvaqlidehsrskqhkvvesqnyfnikveediGLKM 547 Polysphondylium...
NP_767693    429 LLAVDHIAQSMPydEMLSWLLFYTGIlDLKRLPQMeiad----------------------------------prgLVQS 474 Bradyrhizobium ...
ABC42332     439 LKRIEHMAMALPadNLDRWVLFYKSLlDFTADDEVvlpd----------------------------------pygLVKS 484 Pseudomonas chl...
NP_599669    427 IEAIDHVNFAQPwqHFDEAVLFYTALmALETVREDefps----------------------------------pigLVRN 472 Corynebacterium...
EEB86421     433 LERIDHLAQTMSydEMLSWSLFYTTLfQMQKSPMVdvvd----------------------------------pdgLVRS 478 Roseobacter sp....
Q557J8       227 TGSLDHIATCIKngEMNYFVEWYRKClGFKLLSDKdsvatdesenfenelildk----nfyvitksdfkytkkeniGLKM 302 Dictyostelium d...
Feature 1                              # #                      #              #                 
1SQI_A       227 IVVANye----------esIKMPINEPapg-------------rkkSQIQEYVDynggAGVQHIALRTEDIITTIRHLRE 283 Norway rat
XP_002610463 241 KAFEYwkca-------kegLRMPGSSPdvkpkvkfviaeplpgqgpNQVETFLEqhggPGIQHIGLHTPDIISSTRQLRA 313 Florida lancelet
XP_002114442 208 IAAQYwlcteqgiqssngrFKFLLAEPldi-------------svnNHVNGFLKeqegSGIQHIALHTENITNTVGQMKA 274 Trichoplax adha...
XP_002120769 223 KAVLGpqhl------eeqkLKNKVPQVpkfvlce-----alqldkkSLMEDFFSmhqgEGVQHIAFSTNNIVDAISHYKA 291 Ciona intestinalis
EFA85545     548 VVLSNqpvssv--nlttppIMWVISEAavd--------------gkGQVEQFVKfnggSGIQHLAFYTDNIFEAVDYARR 611 Polysphondylium...
NP_767693    475 QAVINgd----------qsLRFVLNGSsa---------------nrTLPARFISeffgSGVQHVAFACRDIFAAVAAMRA 529 Bradyrhizobium ...
ABC42332     485 RALRSrc----------stIRLPLNISen---------------rkTAISHALSsyggSGVHHIAFDCDDIFAEVSRAKE 539 Pseudomonas chl...
NP_599669    473 QVMRSpn----------daVRLLLSVApe----------------dGEQGDFLNa---AYPEHIALATADIVAVAERARK 523 Corynebacterium...
EEB86421     479 QALETad----------gsFRITLNGAet---------------hrTMAGNFLAdsfgASVQHIALSTSDIFATADAMAQ 533 Roseobacter sp....
Q557J8       303 AVLSNqplnts--fhktppIQFVISEAiqg--------------geGQIEQFIHyfggEGVQHLAFNSNNIFKAVEIAKS 366 Dictyostelium d...
Feature 1                                                                                        
1SQI_A       284 RGmeFLAvPSSYYRLLRenlkts---kiqvkeNMDVLEE----LKILVDYde---------------------------- 328 Norway rat
XP_002610463 314 AHvqLLKpPDTYYSEIGklsei-----nqvgqCLTALRE----NGVLLDAeadatdn------------------dtrnn 366 Florida lancelet
XP_002114442 275 AGtaFVTpPDTYYNNLKqadih-----etvklSAEDLKE----NNVLLDFeldkcenegh------------nsngqrrp 333 Trichoplax adha...
XP_002120769 292 SGlqCVLpPDAYYTENFsrnei-----edlnlTVETLKA----NNILLERnqgeaesgsdwcelnfgvsgleeqkqhlkn 362 Ciona intestinalis
EFA85545     612 HLleFIEaPDYYYQNLSkreeldtvlpllskeTINDLYE----YKVLIDSdys--------------------------t 661 Polysphondylium...
NP_767693    530 RGagFLDiPDNYYDDIEakyd-------lapdLMAQLRA----NHILYDReg---------------------------- 570 Bradyrhizobium ...
ABC42332     540 AGvpLLDiPLNYYDDLAarfd-------fddeFLSELAY----YNVLYDRda---------------------------- 580 Pseudomonas chl...
NP_599669    524 RGldFLPvPENYYDDVQarfd-------lpqeFLDTLKE----NHLLYDRde---------------------------- 564 Corynebacterium...
EEB86421     534 RGfkPLPmSENYYADLVarfd-------ldpdMLAALKA----ANILYDEda---------------------------- 574 Roseobacter sp....
Q557J8       367 QKleFVYiPQSYYSKLDerlkh-----lfpnsIPKILKEnlmkFGILIDSdaitntnennsnnnn---nndsqnnteinq 438 Dictyostelium d...
Feature 1                #             #          #   ##         
1SQI_A       329 -kGYLLQIFTKPMqd-rPTLFLEVIQRh-nHQGFGAGNFNSLFKAFEE 373 Norway rat
XP_002610463 367 nqRYLMQVFTKPIfd-eDTFFLEIIQRc-gATGFGAGNITALWRSVQA 412 Florida lancelet
XP_002114442 334 daKYLLQAFTRPLldkkRSFFMEVIQRf-gARGFGGSNIRKSFTAMED 380 Trichoplax adhaerens
XP_002120769 363 tnWFIMQAFTNPVfe-eKTLFFELIQRfqtISGFGAGNIGASWRAAQK 409 Ciona intestinalis
EFA85545     662 tkEKNDHYILQSIcd-tPTFFFEMIKRs-gAVGFGKGNIKALFEAVEM 707 Polysphondylium pallidum PN500
NP_767693    571 -dGEFFQVYTHIFd---ERFFFEIVERr-nYQGFGAANAGIRLAAQSR 613 Bradyrhizobium japonicum USDA 110
ABC42332     581 qgGELFHVYTEPFe---GRFFFEIIQRkngYVGYGAANVAVRLAAMAK 625 Pseudomonas chloroaphis
NP_599669    565 -nGEFLHFYTRTL----GTLFFEVVERrggFAGWGETNAPVRLAAQYR 607 Corynebacterium glutamicum ATCC 13032
EEB86421     575 -qGAFFQFYSQPYa---GGMFFEIVERrggYKGYGAPNAPFRIAAQKR 618 Roseobacter sp. GAI101
Q557J8       439 niGYIKQIFTKYInd-rPTMFFELIERs-nALGFGKGNIIALFESLEK 484 Dictyostelium discoideum AX4

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap