3EY7,3HUH,3ZW5,3HNQ,3EY8


Conserved Protein Domain Family
GLOD5

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cd07253: GLOD5 
Click on image for an interactive view with Cn3D
Human glyoxalase domain-containing protein 5 and similar proteins
Uncharacterized subfamily of VOC family contains human glyoxalase domain-containing protein 5 and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319916
Aligned: 22 rows
Threshold Bit Score: 145.447
Created: 17-Feb-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingdimer interface
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H [DH] [DE]Click to see conserved feature residue pattern help
Evidence:
  • Structure:3EY7_A; metal binding site of a glyoxylase family protein.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                                          
3EY7_A         8 ISHLDHLVLTVADIPTTTNFYEkvLGXKAVSFga--------gRIALEFGH-QKINLHQLGnefep-------------- 64  Vibrio cholerae
3HNQ_A        21 IDRIDHLVLTVSDISTTIRFYEevLGFSAVTFkq--------nRKALIFGA-QKINLHQQExefep-------------- 77  Salmonella ente...
Q54L71         3 IDRLDHLVLTVSDIEKTCNFYEniLGMKVITFgkd------neRKALTFGN-QKINLHKKGaefep-------------- 61  Dictyostelium d...
XP_001786681   4 INRLDHLVLTVSNIDQTCDFYSrvLGMRTVTFge--------gRKALHFGQ-QKINLHEAGkefep-------------- 60  Physcomitrella ...
CAG87857       3 IESLDHLVLTVKNIEESIRFYTsvLGMQVESFkg--------nRKALRFGN-QKINLHEHGhefep-------------- 59  Debaryomyces ha...
EDX86776       9 IEQLDHLVLTVADISITCQFYQsvLGCKVIHFttgs----gdnRCALSIGNhQKINLHSAGsplqp-------------- 70  Synechococcus s...
NP_354538     10 LVGIDHVVFIVDDMTRALDFYRnvLGCTDGYSypa------lgMEQVWCGN-ALIVLWDVThpggtk------------- 69  Agrobacterium t...
ACI64981      70 LQRIDHVVIRCKNFLLMFDFYHriIGATIDEPreehvnrfggsLTHLRAGT-SYIDLLAYDtnhlsedgkvavakmhagg 148 Thalassiosira p...
NP_744713      6 IKHIDHLVLRVSDLPRSVAFYTelLGCTVSRVred------lgMVHLATGT-AMIDLVTLDgplgqpg------------ 66  Pseudomonas put...
YP_001089684   2 IKKIEHVVITNNNIENYINFYKk-FGFSSKEMs---------kKYKLNARN-VKINLNIKGykflp-------------- 56  Clostridium dif...
Feature 1                             #                                                    #    
3EY7_A        65 -----------kaqnVRVGSADLCFITDTv-lSDAXKHVEDQGvtiXEGPVKRTGAQ-GAITSFYFRDPDGNLIEVSTY 130 Vibrio cholerae
3HNQ_A        78 -----------kasrPTPGSADLCFITSTp-iNDVVSEILQAGisiVEGPVERTGAT-GEIXSIYIRDPDGNLIEISQY 143 Salmonella enter...
Q54L71        62 -----------kallPTAGSADLCFITITp-lHEVITELFQKNitiEEGPCERTGALsKPILSVYIRDPDYNLIEISNY 128 Dictyostelium di...
XP_001786681  61 -----------kaksPMPGTADLCFITDDp-iPDVIRHLENCNvviEEGPVLRTGAL-GSITSVYLRDPDGNLIEISNY 126 Physcomitrella p...
CAG87857      60 -----------kachPVPGSADLCFVASTs-iEEVADHLKKNDvtiIEGPVKRTGAI-GSITSLYIRDPDLNLIELSNY 125 Debaryomyces han...
EDX86776      71 -----------aaryPQPGSADLCFLTQTp-lSQVVEHLQSCSisiISGPIRRTGTL-GPILSVYIRDPDDNLIEIANV 136 Synechococcus sp...
NP_354538     70 ---------aappvaGGRNVDHICIATGPlnhDALRAHLAKFNv-tIEQEAFHGGAR-GMGYSFYFRDPFGNKIELKGP 137 Agrobacterium tu...
ACI64981     149 vgtetgtiddvtfssDSSTMDHLCLRVEPfneQQMLKYLEGEGvtiILSGEKRLGAD-GVGPSIYVRDPEGNVIELKGS 226 Thalassiosira ps...
NP_744713     67 ---------gaapgvEGRNLHHFCLRIEPfdeAALTAYLEAAGv-kVEPAEKRYGAE-GEGLSLYCYDPDGNQVELKGP 134 Pseudomonas puti...
YP_001089684  57 -----------yvknLQASRDNLCFKINTn-iDEPKKYLEQNEiqiERGIVECTGVF-GNIKSIYLKKTNGNLIELSNH 122 Clostridium diff...

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