Conserved Protein Domain Family
CRD_SMO
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cd07451: CRD_SMO 
Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein.
The cysteine-rich domain (CRD) is part of the smoothened receptor (Smo), an integral membrane protein and one of the key players in the Hedgehog (Hh) signaling pathway, critical for development, cell growth and migration, as well as stem cell maintenance. The CRD of Smo is conserved in vertebrates and can also be identified in invertebrates. The precise function of the CRD in Smo is unknown. Mutations in the Drosophila CRD disrupt Smo activity in vivo, while deletion of the CRD in mammalian cells does not seem to affect the activity of overexpressed Smo.
Links
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Statistics
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PSSM-Id: 143560
Aligned: 13 rows
Threshold Bit Score: 210.687
Created: 27-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:
  • Comment:Inferred by similarity to other members of the CRD_FZ superfamily.
  • Comment:Wnt binding surface annotation based on mutation analysis of CRD domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           # ##    ###                                   
EAL24102       66 RAAPCEPLRY-----------------------NVCLGSVLPYGATSTLLAgd------sdSQEEAHGKLVLWSGLRNAP 116  human
O42224         36 RPAACERLRF-----------------------GSCLGSALPYAHTSTLLAad------sgSQEEAHGKLLLWSGLRNAP 86   chicken
AAK15464       39 KTTTCEPLKY-----------------------NICLGSVLPYALTSTVLAed------ssSQDEVHDKLSLWSGLRNAP 89   African clawe...
P91682         86 RRARCYPTSNa---------------------tNTCFGSKLPYELSSLDLTdf-------hTEKELNDKLNDYYALKHVP 137  fruit fly
AAK83380       30 KSTTCEVLKY-----------------------NTCLGSPLPYTHTSLILAed------seTQEEAFEKLAMWSGLRNAP 80   zebrafish
NP_001071819   27 SQTGCVDLGN-----------------------TTCFGSDLPYSQTSFELVtd------adTLAGVKEKLLLWSGIRAVP 77   Ciona intesti...
ABI95493       42 RPAACTPLPAn---------------------mTQCLGTEISHTYISLSLAnd------stTIQEVNERLVMWKGLRNVP 94   green sea urchin
XP_395373     150 RHAKCVEIQK-----------------------NTCMGTRLPYTTTTLELIpe------hiTQDIIEEKLHVLQTLRHVP 200  honey bee
XP_001949027   20 CSTPQVLLGLsksksklqycerphsrcldmnhsLSCLGVKLPYTSTSTDLVpd------aeTPEEAQERLHYWQGLKKVP 93   pea aphid
NP_001127850   53 KPAKCQLLNY-----------------------TTCMGMKLPYFSTTLELTdl-------tTQEKVQEKLHHYKYLRFIP 102  red flour beetle
EEB12552       50 CRKSAECTSSn----------------------LTCFGVPLPYSDISSDVVvdlfkspelqNFHNLQQELNKWEILRKVP 107  human body louse
XP_001602300   63 KPAKCVKMIN-----------------------TTCLGATLPYDTTSLDLMpk------ytTQEMIMEKLHILRGLEHIP 113  jewel wasp
XP_001632182   22 GSYKCEPLKE-----------------------QTCLGEKLDYHYTTTELVtd------ssSQDQVKKNLEKWEGLKFLP 72   starlet sea a...

Feature 1                                                                                         
EAL24102      117 RCWAVIQPLLCAVYMPKCENd----rVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFp---EGCTNEVQn-IKFN 188  human
O42224         87 RCWDVIQPLLCAVYMPKCEDg----qVELPSQTLCQATRAPCTIVERERGWPDFLKCTPDRFp---EGCPNEVQn-IKFN 158  chicken
AAK15464       90 RCWDAIRPLLCAVYMPKCEGg----kVELPSQGLCQTTRVPCAIVARERGWPDFLKCTTDYFp---EGCPNEVQn-IKFN 161  African clawe...
P91682        138 KCWAAIQPFLCAVFKPKCEKingedmVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFp---TKCTNGARg-MKFN 213  fruit fly
AAK83380       81 RCWAVIQPLLCAVYMPKCENg----kVELPSQHLCQATRNPCSIVERERGWPNFLKCENKEQf--pKGCQNEVQk-LKFN 153  zebrafish
NP_001071819   78 LCWDAIQPLLCSVYFPECGEn----kIQLIDRKVCQATRQPCKIVEVEYGWPDFLRCDNNDVy--aDQCESPSTk-LLKF 150  Ciona intesti...
ABI95493       95 KCWEVVQPLLCALYMPKCEDg----rVELPSFDMCTVVQSPCRIVELERGWPHFLQCNEEHMpr-eCSEPNSYKa-VTFN 168  green sea urchin
XP_395373     201 KCWAVVQPLLCSIFMPKCINd----tVDLPSQEMCKMVSGPCRIVFNHTIWPSFVKCENTDLf--pRLCKNDIRe-LKFN 273  honey bee
XP_001949027   94 KCWAAIQPLLCALYMPNCENs----sLHLPPQEMCKLIENHCQILKIENSWPAEFNCENDTIyp-aKLCKNDLRelKFNS 168  pea aphid
NP_001127850  103 KCWAVIQPFLCALYMPKCENg----kVDLPSREMCQLTLKPCKMFYNSSIFPKFLNCDDERIf--sSNCKNDVQe-LRFN 175  red flour beetle
EEB12552      108 KCWQTLQPFLCALYLPKCEYd----tVYLLSQERCKYTMSTCKILKEPLFAATFPSINCDATeffpRTCKNDVKd-LRSN 182  human body louse
XP_001602300  114 KCWAVVQPFLCSLFLPKCVNd----tVDLPSQEMCKVVSGPCKILLNHTIWPNFIKCDNEELf--sRSCKSEIRe-LKFN 186  jewel wasp
XP_001632182   73 KCWEVLQPFLCQIYKPKCKNg----sVELPCREQCFATRKPCSVVESYRRWPEFLRCDKLPE----GNCNGTLK--KLHL 142  starlet sea a...

Feature 1                 
EAL24102      189 SSGQCEVP 196  human
O42224        159 SSGQCEAP 166  chicken
AAK15464      162 SSGQCEAP 169  African clawed frog
P91682        214 GTGQCLSP 221  fruit fly
AAK83380      154 TSGQCEAP 161  zebrafish
NP_001071819  151 NASGCEPP 158  Ciona intestinalis
ABI95493      169 LTGGCEPP 176  green sea urchin
XP_395373     274 ISSKCLKP 281  honey bee
XP_001949027  169 TAGRCESP 176  pea aphid
NP_001127850  176 TTGFCMEP 183  red flour beetle
EEB12552      183 LSGECISP 190  human body louse
XP_001602300  187 TSSSCLYP 194  jewel wasp
XP_001632182  143 NESACKAP 150  starlet sea anemone

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