Conserved Protein Domain Family
P-type_ATPase_Cu-like

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cd07552: P-type_ATPase_Cu-like 
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase
Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Statistics
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PSSM-Id: 319850
Aligned: 18 rows
Threshold Bit Score: 939.806
Created: 19-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
AAB91079      65 STLLTIPILILSPAIQtfl--gfRVEFAGSLYILFLLSSAVYFYGGYPFLKGIFdELRRRQPGMMTLIAVAISVAYFYSS 142 Archaeoglobus f...
AAS20123      74 SLALSVPVVYFSPMFAhll-gyhIPEFPGSLWIPPVLGSVIFFYGGTPFLKGGWtELRSRQPGMMLLIAMAITVAFVASW 152 Arthrobacter au...
AAB85258      45 CLLMTIPVILLGELPTgn----vLFSFEGSEFLVLILSSAIFLYGGYPFLRGSLrELSSRTPGMMTLIAVAITVAYTYSL 120 Methanothermoba...
YP_144999     54 SLLLTLPILYFSEQLQtwl-gyrALAFPGSAWVNPVLGTILYFYGGLVFLKGALgELRERAPGMMTLIALAITVAYGYSL 132 Thermus thermop...
AAC07161      35 TTILTVPVVVLSPSIQeli--giKVSFPYSNWVILLLSTAVFIYGGTFFLKGMLeELKKKNPGMMTLVGLAISVAYIYSV 112 Aquifex aeolicu...
P05425       110 SLILAIPIILFSPMMGmsf--pfQVTFPGSNWVVLVLATILFIYGGQPFLSGAKmELKQKSPAMMTLIAMGITVAYVYSV 187 Enterococcus hi...
ABW05004      74 SVVLAIPVLLLAPIMGlnvsilsFSSPLIVGIIIVLFDTALYFYGGMPFLKGAKaEIQNKSPEMMTLVTLGISVSYFYSL 153 Lactobacillus r...
YP_004890865  40 ALVLTIPIIIMSPMMGvnl-pfqIVFRPWSDYIVAILGTILFLYGGQPFFSGAKaEVKNHKPAMMTLITMGISVAYVYSI 118 Lactobacillus p...
NP_814614     62 SLILAIPIIVLSPMMGfql--pfQFTFPGSDWLVLILATVLFFYGGQPFLSGARmELQQKSPAMMTLIAMGISVSYFYSL 139 Enterococcus fa...
O30085        65 STLLTIPILILSPAIQtfl--gfRVEFAGSLYILFLLSSAVYFYGGYPFLKGIFdELRRRQPGMMTLIAVAISVAYFYSS 142 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     143 AVVFGl-------kGKFFFWELATLIDIMLLGHYIEMRSVLGASRALEELVKIMPSEAHLLkd-gEIVEVKVENLKPGDK 214 Archaeoglobus f...
AAS20123     153 ITTLGig-----nfNLDFWWELALLVVIMLLGHWIEMRALGSARGALDALAELLPDEAERIte-hGTETVSISELSVNDV 226 Arthrobacter au...
AAB85258     121 GVILGl-------eGMVFFVELVTLIDVMLLGHWIEMRSIMSASGAVERLAGLLPRRAHLVvd-gKVEDVDVSTLKPGDI 192 Methanothermoba...
YP_144999    133 AVSLGl-------pGMPFYWELATLIDVMLLGHWLEMASVQAASRALEELAKLMPATAHRItg-dRIEDVPVTALKEGDL 204 Thermus thermop...
AAC07161     113 YTFFFg--------GKEFFWELTTLIVVMLWGHYVEMKSVLGAGRALEELVKLIPSKAHLVtq-kGLIDVPVEKLKKGDL 183 Aquifex aeolicu...
P05425       188 YSFIAnlin-phthVMDFFWELATLIVIMLLGHWIEMNAVSNASDALQKLAELLPESVKRLkkdgTEETVSLKEVHEGDR 266 Enterococcus hi...
ABW05004     154 YAFIAnnflnptnhIMDFSFELATLILIMLLGHWIEMNALMGAGNALQKMAALLPKTAHLVtdngETKEVPVSDLKVGQA 233 Lactobacillus r...
YP_004890865 119 YAVVAngllnakpmVTDFFWELATLIVIMLLGHWIEMNTVMNAGSAVDKLAKLLPSTAHKLvd-gQVHDVAIADLANGDQ 197 Lactobacillus p...
NP_814614    140 YAFYMnhft-nqahVMDFFWELATLIVIMLLGHWIEMNAISNAGDALKKMAELLPDTVKRMte-hGEEEIPLQDVQEGDR 217 Enterococcus fa...
O30085       143 AVVFGl-------kGKFFFWELATLIDIMLLGHYIEMRSVLGASRALEELVKIMPSEAHLLkd-gEIVEVKVENLKPGDK 214 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     215 VLVKPGEKIPVDGIVVEGeSFVNEAMLTGESKPVAKKPGDTVIGGAINGEGSLVVEVEKTGKDTYLNQVIELVRQAQESK 294 Archaeoglobus f...
AAS20123     227 VLVRSGARLPADGEIIEGrAELDESMITGESKTVPRGPGDTVVAGTVATDSAVRIRVGAVGTDTALAGIQRLVAEAQASS 306 Arthrobacter au...
AAB85258     193 VVVRSGERVPSDGTVIRGeSHVNESLLTGESRPIKKVPGDGVIGGSINTGGSLTVEVERVGEESFISQIIELVGRAQEGR 272 Methanothermoba...
YP_144999    205 ILVRPGEQVPADGVVEEGaSSVNEAFLTGESRPVPKGVGDEVLAGAVNGEGSLKVRVTRTGEATTLSQVMRLVQEAQASR 284 Thermus thermop...
AAC07161     184 VLVRPGEKIPTDGTVVEGnTHVDESMLTGESRPVPKKPGDKVIGGSVNLEGSIKVRVEKTGEETYLKQVIKLVKEAQESK 263 Aquifex aeolicu...
P05425       267 LIVRAGDKMPTDGTIDKGhTIVDESAVTGESKGVKKQVGDSVIGGSINGDGTIEITVTGTGENGYLAKVMEMVRKAQGEK 346 Enterococcus hi...
ABW05004     234 FQVRSGESIPADGVITAGeSTVNEALVTGESAAVTKNVGDKVIGGTTNNNGTLTVKISGTGDSSYLSQVMKMVQNAQQAK 313 Lactobacillus r...
YP_004890865 198 VQVRAGEQIPADGTVLNGaTSVNEAMVTGEAKLVEKRAKDQVVGGSVNGDGTFEMKVTGTGESGYLAQVMKLVSDAQAAK 277 Lactobacillus p...
NP_814614    218 LIVRSGDKIPTDGKILKGsTTVDESMVTGESKTVEKNIGDSVIGGAVNGNGMIEISVTGTGENSYLSKVMEMVKQAQSEK 297 Enterococcus fa...
O30085       215 VLVKPGEKIPVDGIVVEGeSFVNEAMLTGESKPVAKKPGDTVIGGAINGEGSLVVEVEKTGKDTYLNQVIELVRQAQESK 294 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     295 SRTQdLANRAALLLTVIALTVGSVTLAIWLAYiaDFAFAIERAVTVMVITCPHALGLAIPLVVAVSTSLAAKSGLLIRDR 374 Archaeoglobus f...
AAS20123     307 SKAQaLADKAAAFLFYFALGAGIITFIAWVLLg-SPDEAVIRTVTVLVIACPHALGLAIPLVIAISTEQAARAGVLIKNR 385 Arthrobacter au...
AAB85258     273 TRTQvLADKAAFWLTSIALLGGLLTFIAWSWLgmDVFFSLERAVTLMVTACPHALGLAIPLVIAVSTAISAGRGILIRNR 352 Methanothermoba...
YP_144999    285 SRFQaLADRAAGWLFYIAVALGMLTFLVWLALgrDFNFALSLAVTVLVIACPHALGLAIPLVTVNATALAAKNGILVRNR 364 Thermus thermop...
AAC07161     264 TKLQsLADRAAFYLTVIAVSLGSISLLFWWYYlgDLNFAVERAVTVMVTACPHALGLAIPLVVSISTSYSARNGILVRNR 343 Aquifex aeolicu...
P05425       347 SKLEfLSDKVAKWLFYVALVVGIIAFIAWLFLa-NLPDALERMVTVFIIACPHALGLAIPLVVARSTSIAAKNGLLLKNR 425 Enterococcus hi...
ABW05004     314 SKAEdKADLVAKYLFYAALGVGIIAFFAWLPQ--GLATAMTIMVTVFVIACPHALGLAIPLVVSRSTTIGAQNGLLVRNR 391 Lactobacillus r...
YP_004890865 278 SSQEnMADKVAGLLFYAALTVAIVAFIVWLLVg-NLALALSIAVTVLVIACPHALGLAIPLVVARSTAIAASHGLLIRNR 356 Lactobacillus p...
NP_814614    298 SKLEsISDRVAKWLFYIALFVGVLAFIGWLMAtkDLSLAFERMVTVFIIACPHALGLAIPLVIARSTSIAAKNGLLLKNR 377 Enterococcus fa...
O30085       295 SRTQdLANRAALLLTVIALTVGSVTLAIWLAYiaDFAFAIERAVTVMVITCPHALGLAIPLVVAVSTSLAAKSGLLIRDR 374 Archaeoglobus f...
Feature 1                      #######                                                           
AAB91079     375 QAFERAKDLQAVIFDKTGTLTEGRFGVTDIVGf--nHSEDELLQIAASLEARSEHPIAAAIVEEAEKRGFglteVEEFRA 452 Archaeoglobus f...
AAS20123     386 IALERMRTIDVVLFDKTGTLTKGQPGLTGVAAie-eMNDDDVLALAAAVEADSEHPSARAIVTAARERGLrvpaASGFAS 464 Arthrobacter au...
AAB85258     353 ESFENARDPDVVVFDKTGTLTMGELGITDVISfdpeMDEGEILSYAAAVESGSSHPIARGIVEAVAEVLP----VENFNS 428 Methanothermoba...
YP_144999    365 EAFERGREIRFVALDKTGTLTEGRFAVRAVYAh--eTSEEEALSLAAALEALSEHPLAQAIVEAAEGKGLprpeVRDFQA 442 Thermus thermop...
AAC07161     344 LALEKAKDIDVVVFDKTGTLTEGKLGVTEVITk--dIEEGEFLKFVASVENHSEHVIARAIVSYAKEKEE----VKNFKA 417 Aquifex aeolicu...
P05425       426 NAMEQANDLDVIMLDKTGTLTQGKFTVTGIEIldeaYQEEEILKYIGALEAHANHPLAIGIMNYLKEKKItpyqAQEQKN 505 Enterococcus hi...
ABW05004     392 QAIEASQHVSHVLLDKTGTLTEGKFTVNALIPnd-gIDETTLLSRLAALEINSTHPLAQAIITEAQAKNIevvaAEKSQN 470 Lactobacillus r...
YP_004890865 357 DAMEQVKKLNYALMDKTGTLTAGNFKVADYQSsayrLTADAVLAMMAGLENGSSHPLAVGILAAAKEHQLtpkvSQDVHQ 436 Lactobacillus p...
NP_814614    378 NALEQANKVEYVLLDKTGTLTEGQFTVTGLELmskqFTREEALKYIGALEKNANHPLAIGIMNYLNKQAVqpyeAHNLQA 457 Enterococcus fa...
O30085       375 QAFERAKDLQAVIFDKTGTLTEGRFGVTDIVGf--nHSEDELLQIAASLEARSEHPIAAAIVEEAEKRGFglteVEEFRA 452 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     453 IPGKGVEGIVNGRRYMVVSPGYIRElgiktdESVEKlk----qqGKTVVFILKNGEVSGVIALADRIRPESREAISKLKA 528 Archaeoglobus f...
AAS20123     465 LTGRGVKADIGASAVMVGGPNLIAAeglgvpSELREqtrpwverGASVLHVIRAGEVIGAVSLEDEVREESRQAITALQK 544 Arthrobacter au...
AAB85258     429 LEGRGVMGHVNGSVVKVLSYGYTEElgfsisDPRVDeli---gqAKTTVFVIVDDELRGCIALADMIRPEAREAVGILRS 505 Methanothermoba...
YP_144999    443 VPGKGVEGTLGGKRYRVGRPEWAEElglkvsEPLKRglkeaearGESVVALMDEARVLALLALADRIRPSAKEAIRRLKA 522 Thermus thermop...
AAC07161     418 FPGKGVCGEVSGRNVCVGTLEFLKEinvkldEELVErarslqseGKTVVFASMDGKLAGIIALADRIKEESYEAVRSLKE 497 Aquifex aeolicu...
P05425       506 LAGVGLEATVEDKDVKIINEKEAKRlglkidPERLKnye---aqGNTVSFLVVSDKLVAVIALGDVIKPEAKEFIQAIKE 582 Enterococcus hi...
ABW05004     471 IPGVGISGNVDGTDYMIVNGNYLTKqgirfdEAAADkwa---akGNSVSFLLQGTQVQGMVAEGDTIKAGAKELISGLQR 547 Lactobacillus r...
YP_004890865 437 ITGVGLSGTIDGQTYQIVSAAYLDKqnlaydQQTFNrla---saGNSVSFLIQEQTVLGFVAQGDQIKPEAKNLIDSLKA 513 Lactobacillus p...
NP_814614    458 LSGVGLVATVQNQEVKIVNEKEVARlqltfdETIKTnyq---eqGNTLSYLIIAGQLVALLALGDKVKPEAKTFIAELQA 534 Enterococcus fa...
O30085       453 IPGKGVEGIVNGRRYMVVSPGYIRElgiktdESVEKlk----qqGKTVVFILKNGEVSGVIALADRIRPESREAISKLKA 528 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     529 IGIKCMMLTGDNRFVAKWVAEELGLdDYFAEVLPHEKAEKVKEVQQKYv-TAMVGDGVNDAPALAQADVGIAIGAGTDVA 607 Archaeoglobus f...
AAS20123     545 RGIRVAMITGDAHQVANAVAAELNIdEVFAQVLPQDKDKKVGELQSRGlkVAMVGDGVNDSPALARAEVGIAIGAGTDVA 624 Arthrobacter au...
AAB85258     506 RGVRCLMLTGDSSAVAGWVASEVGIdDYMAELIPIEKYDEIRKLQEEGlrVVMVGDGVNDAPALVQADIGVAIGAGTDVA 585 Methanothermoba...
YP_144999    523 MGITPVMITGDAEAVARTVAQELGIeRYHARVLPEDKARRVRELKREGp-TAFVGDGINDAPALLEADLGIAIGAGTNVA 601 Thermus thermop...
AAC07161     498 LGKKVVMITGDSEEVAKYVAKELEMdEYFARVLPHEKAQKIKELQDRGysVAMVGDGVNDAPALIQADVGIAIGSGTDIA 577 Aquifex aeolicu...
P05425       583 KNIIPVMLTGDNPKAAQAVAEYLGInEYYGGLLPDDKEAIVQRYLDQGkkVIMVGDGINDAPSLARATIGMAIGAGTDIA 662 Enterococcus hi...
ABW05004     548 RGITPVMLTGDNPKAAEHVANLLGLtEFHAGLLPDDKQKIIADYQAKGnhVIMVGDGVNDAPSLAAADIGIAIGAGTDVA 627 Lactobacillus r...
YP_004890865 514 QNITPVMLTGDNPQSAQVVAKQLGItEVHAGLLPEDKAKLVQQYQADGshVMMIGDGVNDAPSLARADIGVAIGSGTDVA 593 Lactobacillus p...
NP_814614    535 QGITPVMLTGDNQTAASAVANYLGMkEYYAELLPEDKEKIVQQYLTEGhqVMMVGDGINDAPSLARASIGIAIGAGTDVA 614 Enterococcus fa...
O30085       529 IGIKCMMLTGDNRFVAKWVAEELGLdDYFAEVLPHEKAEKVKEVQQKYv-TAMVGDGVNDAPALAQADVGIAIGAGTDVA 607 Archaeoglobus f...
Feature 1                                                                                        
AAB91079     608 VETADIVLVRNDPRDVAAIVELSRKTYSKMKQNLLWATGYNAFAIPLAAGVLYSAGILLSPAVGAILMSLSTVIVAINAR 687 Archaeoglobus f...
AAS20123     625 MESAGVVLAGNDPRAVLSMVDLSRASYRKMIQNLVWATGYNVIAVPLAAGVLAFAGVAISPAVAAVLMSVSTIVVALNAQ 704 Arthrobacter au...
AAB85258     586 IESADVVLVRSNPLDVVDLMDLAAATYSKMKENLIWATGYNVIALPLAAGVLYGQGIILSPAMGAILMSLSTVIVALNAR 665 Methanothermoba...
YP_144999    602 IEAADLVLVESDPLDVVRALTLARATHAKMVQNLFWATGYNAIALPLAAGVAYPWGIVLSPAVGALLMSLSTVAVAVNAM 681 Thermus thermop...
AAC07161     578 IESADVILVKSDPRDVVKVIKLSQVTVSKMLQNLFWAVGYNVITLPLATGLGYPWGFVLKPAVGAIFMSASTVIVALNSM 657 Aquifex aeolicu...
P05425       663 IDSADVVLTNSDPKDILHFLELAKETRRKMIQNLWWGAGYNIIAIPLAAGILAPIGLILSPAVGAVLMSLSTVVVALNAL 742 Enterococcus hi...
ABW05004     628 IDSADVVLVKSEPSDILHFLDLAKITNRKMVQNLWWGAGYNVVAIPLAAGVLSFIGIILDPAVGAAVMAMSTIIVAINAM 707 Lactobacillus r...
YP_004890865 594 IDSADIVLVKSNPNDVVDFLALARRTTRKMAQNLWWGAGYNVITIPLAAGILAPLGFILNPMFGAVVMSLSTVIVAINAM 673 Lactobacillus p...
NP_814614    615 IDSADVVLTDSDPKDILRFLDLAKQTRRKMIQNLWWGAGYNIVAIPLAAGVLAPIGIVLNPAVGAVLMSLSTIIVAANAM 694 Enterococcus fa...
O30085       608 VETADIVLVRNDPRDVAAIVELSRKTYSKMKQNLLWATGYNAFAIPLAAGVLYSAGILLSPAVGAILMSLSTVIVAINAR 687 Archaeoglobus f...
Feature 1           
AAB91079     688 LLR 690 Archaeoglobus fulgidus DSM 4304
AAS20123     705 LLR 707 Arthrobacter aurescens
AAB85258     666 TFS 668 Methanothermobacter thermautotrophicus str. Delta H
YP_144999    682 LLR 684 Thermus thermophilus HB8
AAC07161     658 LMK 660 Aquifex aeolicus VF5
P05425       743 TLK 745 Enterococcus hirae ATCC 9790
ABW05004     708 GLT 710 Lactobacillus reuteri
YP_004890865 674 TLR 676 Lactobacillus plantarum WCFS1
NP_814614    695 TLH 697 Enterococcus faecalis V583
O30085       688 LLR 690 Archaeoglobus fulgidus DSM 4304

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