3R4Q


Conserved Protein Domain Family
VOC_like

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cd08354: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319942
Aligned: 8 rows
Threshold Bit Score: 177.943
Created: 30-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative metalhomodimer
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:E H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homologous proteins in the same superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #                                                                             
3R4Q_A      9 IMETALYADDLDAAEAFYRdVFGLEMVLklPGQLVFFKCGR-QMLLLFDpqessradan--------------------- 66  Agrobacterium fabr...
NP_635587   1 MLETGVYVADLDRACAFYAqVLGLQPMHr-DARMAAYAIAPaQVLLLFLqgsttttvrlp-------------------g 60  Xanthomonas campes...
NP_295930   3 ALETCLYADDLSAAEAFYSgVLGLTLHSkvAGRHLFYRLDG-SMLLIFNpeasakpg----------------------- 58  Deinococcus radiod...
YP_144821   3 VLETSVYAEDLEKARAFYEgVLGLPCFQfkPPRHAFFRAGR-GVFLVFNpkltaket----------------------- 58  Thermus thermophil...
YP_446160   8 ALETSLYADDLAAAEQFYGdVLGLDVMLrtEGNHITFRCGP-GVVHVFDpaasrdrt----------------------- 63  Salinibacter ruber...
EEE45682   15 ILETAVYVDDMDAAHGFYEgILGLKRMVa-GDRLFAYDAGPaQTLLVFYrghtgedvptp-------------------g 74  Labrenzia alexandr...
EDY82674    6 IFETILYAEDLPAAKLFYRdTLGLELMRe-SELVLVFRLQD-SVLLVFDprkssppgr---------------------- 61  Verrucomicrobiae b...
XP_681176  13 VLETCLYVRDIHASRKFYEdVLNIKPFMq-SHRSACFSLGN-TTLLLFQlgqtdadittpsgvipghgpsaqivaklnaa 90  Aspergillus nidula...
Feature 1                 #                                                #    
3R4Q_A     67 npiprhgavGQGHFCFYADDkAEVDEWKTRFEALEiPVEHyhrwpnGSYSVYIRDPAGNSVEVGEG 132 Agrobacterium fabrum str. C58
NP_635587  61 gtipphdghGHTHYALAIAT-ESLAAWEAHLHACDvAIEGrtqwpgGGQSMYFRDPDDHLVELATP 125 Xanthomonas campestris pv. campe...
NP_295930  59 -dvpshqgkPGGHACLAIPR-EQTAEWETRLRGHGlDVTRyaw-geRGESLYFDDPAGNVLELAPA 121 Deinococcus radiodurans R1
YP_144821  59 -hlpphgakGSVHVAFRVEE-EELPAWEARLKAAGyPVWWae--wpKGKSLYTQDPAGNLVELAPA 120 Thermus thermophilus HB8
YP_446160  64 -slpahgaeGPVHVAFGVPT-DQLAAWRRHFNRHDvAVEDttqwgdGQRSLYVRDPAGNSVELVSS 127 Salinibacter ruber DSM 13855
EEE45682   75 givpghdtsGHGHFAFRILN-DQLGPWRDYLSSKGvDIISevvwpaGGTSLYFKDPDGNILELASA 139 Labrenzia alexandrii DFL-11
EDY82674   62 -avpshgtsGEGHIAFAATD-EEIREWRVHLESKGiEIESvvewgeGGESLYVRDPAGNSVEFAPS 125 Verrucomicrobiae bacterium DG1235
XP_681176  91 kegdgdidsLKQHFCVAVQStEDVAKWEAYLQKKGvPIISctnwerGGKSIYFADLDGHLAEIASR 156 Aspergillus nidulans FGSC A4

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