4JD1,4NB1


Conserved Protein Domain Family
FosB
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cd08363: FosB 
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fosfomycin resistant protein subfamily FosB
This subfamily family contains FosB, a fosfomycin resistant protein. FosB is a Mg(2+)-dependent L-cysteine thiol transferase. Fosfomycin inhibits the enzyme UDP-nacetylglucosamine-3-enolpyruvyltransferase (MurA), which catalyzes the first committed step in bacterial cell wall biosynthesis. FosB catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin, (1R,2S)-epoxypropylphosphonic acid, rendering it inactive. FosB is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.
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Statistics
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PSSM-Id: 319951
Aligned: 10 rows
Threshold Bit Score: 221.456
Created: 20-Mar-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative Mgputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative Mg binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:putative Mg(II) binding site
  • Comment:predicted based on binding of Mn(II) to a homologous protein FosX.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                                                          #                  
4JD1_A         6 INHICFSVsNLEKSIEFYQKilQAKLLVKGrKLAYFDLNGLWIALNveeDIPRNEIKQSYTHMAFTVTNEALDHLKEVLI 85  Bacillus anthra...
Q5WE80         5 INHMTFSVsNMDKAVSFYKHvfMEAPLVLGeKTAYFTIGGTWLALNlqpDIDRKEIRQSYTHIAFSIEESQLDAFYTRLL 84  Bacillus clausi...
P59291         6 VNHICFSVsDLNTSIQFYKDilHGDLLVSGrTTAYLTIGHTWIALNqekNIPRNEISHSYTHIAFSIDEEDFQQWIQWLK 85  Staphylococcus ...
Q65KJ5         9 INHLLFSVsDLSVSISFYEKvfDAKWLVKAeKTAYFDLNGIWLAFNeekDIKRQEIHDSYTHIAFSIQQEDLPFWEKKLH 88  Bacillus lichen...
4NB1_A        12 INHICFSVrNLNDSIHFYRDilLGKLLLTGkKTAYFELAGLWIALNeekDIPRNEIHFSYTHIAFTIDDSEFKYWHQRLK 91  Staphylococcus ...
WP_043069182   6 INHLTFSVvNLEASIAFYRDvlEGTLLVQGeRMAYFDLQGIWLALNvqeDIPRTEITHSYTHIAFTIDEQDFPVYVQRLQ 85  Aneurinibacillu...
WP_054710948   5 LNHITFSVsNLEQTVAFYKQvfLIDPVVYGqKTAYFDINGMWLALNvqdQIPRNDVYHTYTHLAFSINKEEIDAFLERLH 84  Bacillus sp. JC...
WP_019424186   7 LNHLCFSVsNLDSSIAFYRDilEGKLLALGrKLAYFDCQGLWIALNq-eDVDRSNRDVTYTHIAFSIDERDYDAVKQRLL 85  Paenibacillus s...
WP_042428302   3 INHITFSVsHLKKSIEFYETalDAKILVEGeRMAYFDLAGVWLALNvqtDIPRNEISHSYTHMAFTVTPEELQMKKENFT 82  Geomicrobium sp...
WP_050615800   5 INHITVSVsDLNRSIAFYQDvfGAKLIVHGpRMAYFDLDGLWLALNe-eNLPDRTFSNTYTHIAFTICEDQLDEFTEKLK 83  Bacillus sp. SIT10

Feature 1                                       #                    
4JD1_A        86 QNDVNILPGRERder-dqrSLYFTDPDGHKFEFHTGTLQNRLEYYKEDKKHM 136 Bacillus anthracis str. Ames
Q5WE80        85 EAGADILPGRKRqvetegkSIYFRDPDGHLLEVHTGTLAERLAHYEKTAPDM 136 Bacillus clausii KSM-K16
P59291        86 ENQVNILKGRPRdik-dkkSIYFTDPDGHKIELHTGTLKDRMEYYKCENTHM 136 Staphylococcus epidermidis ATCC 12228
Q65KJ5        89 DLGVNVLKGRKRheg-drdSIYFSDPDGHKFELHTGSVFDRLQYYQNEKPHL 139 Bacillus licheniformis
4NB1_A        92 DNNVNILEGRVRdir-drqSIYFTDPDGHKLELHTGTLENRLNYYKEAKPHM 142 Staphylococcus aureus subsp. aureus N315
WP_043069182  86 KLGVTIREGRSRdka-eaqSVYFTDPDGHLFEFHTGNREQRIQHYKDEKKPM 136 Aneurinibacillus migulanus
WP_054710948  85 LSGAEIVEGRTRdilsegqSLYFRDPDGHLLEVHTGSLAERLEHYKKNAPEM 136 Bacillus sp. JCM 19041
WP_019424186  86 DYGVTVLEGRERaqe-dkrSIYFLDPDHHCFEFHTGTLEARLQYYRSSKRHI 136 Paenibacillus sp. OSY-SE
WP_042428302  83 KVGISYDEGRDRdkgreghSIYFSDPDGHRFELHTGSRDQRIEYYKEEKKPM 134 Geomicrobium sp. JCM 19039
WP_050615800  84 RNGAVIEKGRKRhll-ekdSIYFRDPDGHLFEFHTGTLTDRISYYKSQQANM 134 Bacillus sp. SIT10

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