1BYY


Conserved Protein Domain Family
Na_channel_gate
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cd13433: Na_channel_gate 
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Inactivation gate of the voltage-gated sodium channel alpha subunits
This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Links
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Statistics
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PSSM-Id: 240441
Aligned: 72 rows
Threshold Bit Score: 54.8784
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic latch
Evidence:
  • Comment:Might be involved in fast closing of the sodium channel, occluding the pore via a hinged-lid mechanism
  • Citation:PMID 9893979
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ####                                   
1BYY_A       1 DNFNQQKKKFGg---qDIFMTEEQKKYYNAMKKLGSKkpqKPIPRPANKFQGMVFD 53   Norway rat
AEW90239  1504 DNFYRLKKQYDdcgtvEVFLTTEQKQWFSTVKKALTKkpkHIIHRPKNFYQAKLFD 1559 Clytia hemisphaerica
EDO46797  1052 DNFNTLKKKYEeinsmGMLLTESQRKWVQILMAAAKRkppSNRLRPTDCFRGKLFD 1107 starlet sea anemone
AEX00072  1143 DNFNTLKRKYDelsgmGMLLTERQRKWVDMLKEAAKTrtpSQAIRPNDIIRGCIFD 1198 starlet sea anemone
AEW90237  1137 DNFYRLKKQFDgcktvEVNLSALQKQWFLSVKNALSKksnRLLQRPKGCYFSKLFD 1192 green hydra
CCA18882  1290 DNFNRMKAALGg----DFMLTPEQKKWIEAQKAALRIgpvRLVKVPKNKYRKWIHT 1341 Albugo laibachii Nc14
EGZ10921  1221 DNFNRMKAALGg----DFMLTPEQKKWVEAQKAASRVgpvRILKPPRQMWRRYIFF 1272 Phytophthora sojae
AEF59076  1028 DTFNRLKAELKeg--rNLFLTEGQQQFITQLQSALRAkpkRRYERPQRRWRGWCYD 1081 Monosiga brevicollis
EGZ10885  1061 DNFNTMKAKLGg----DFLLTPEQKKWMEAQKSATRIgpiRILKPPPLSVRRLCFT 1112 Phytophthora sojae
EGZ10886   874 ENFNTMKAKLGg----DFLLTPEQKKWMEAQKSATRIgpiRMVNAPTQVLRRVCFS 925  Phytophthora sojae

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