Conserved Protein Domain Family
7tmD_STE3

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cd14966: 7tmD_STE3 
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors
This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.
Statistics
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PSSM-Id: 320097
View PSSM: cd14966
Aligned: 179 rows
Threshold Bit Score: 184.241
Threshold Setting Gi: 400223
Created: 14-Feb-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #########################                                                      
Q8J1P8      5 STIIGLCLLAVILLVPPLAWHSHTKNIPAiiLITWLLIMNITCIVDAAIWSDDDFLTrwd-gkgWCDIVIKLQVGANIGI 83  Saccharomyces para...
CCX09282    6 HIFRTLTAVSLILCCMPLVWHIRYKNFPAvfLIVWISFFSISSFVNSFIWPDNNSIQhgwngkvYCDIQIKLKVAAFAGN 85  Pyronema omphalode...
CCJ29170    4 VFYVIYSFIGFICSVIPSIWHWKYRNVAPlcLIFWISACSLICFINSIVWFNGVEAKspg--yiYCDIATKIILGSTSGE 81  Pneumocystis jirov...
ETI23274    8 LVLAPLALLAVLAAIPPLIVQVRARNFPAsvLIAGVTILNIQNFVNAAIWHSLDTSRwwn-gkiLCDIEVKLYLGTTQAM 86  Cladophialophora c...
AAG38536    4 AFYIFFCLIGFLCSIIPSIWHWKYRNVAPlcLIFWVSSTNLVYFINSIIWYNGSETSyrg--dlYCDIVTKLILGSVTGE 81  Pneumocystis carinii
ETN40645    9 IAYTPLALLSLILSVPSLVIQGRARNFPTivLIACIAVLNLQNVANAFIWPGWGDNPweg--riFCDIEIRLYAALPTAV 86  Cyphellophora euro...
P31397      6 IFYQFYAYFALVLSIPILYMQLRARNIPCllLLFWLTLTTLIYVVESAIWSNPYAETirwmgygLCDITSRIVTCSSIGI 85  Schizosaccharomyce...
EPY53252    6 IFYQVYAYFSLVLSVQVFYMQMRARNLPCllLLFWVCICSLIYAVQSAIWHDTSEPKwlg--ygFCDLTSRIITSSSIGI 83  Schizosaccharomyce...
EGX48668   87 GFFVFCSITAIIGLVVPFIWQIRRENVAAalLCFWLQTDLLFCLTDAIIWPTWKSVItgwqgrgYCDFVIKWKLAAEFGA 166 Arthrobotrys oligo...
EPS42569   80 YIFAICCFSSIILLIIPFIWQVRKRNLAAaiLVFWLQSDLLLSFINALIWPTWVSVVtgwqgkgYCDFVVKWKIAAEFGG 159 Dactylellina hapto...
Feature 1                                                                                     
Q8J1P8     84 SCAVTNIIYNLhailkadsv---lpdlsswtkIVKDLVISLFTPVMIMGFSYLLQVFRYGIArynGCQNLLSPTWITTIL 160 Saccharomyces para...
CCX09282   86 LGALAAISRNLarvvsrktig--eskserkraLIQDTMLCVGAPIFMTITHYVVQPSRYDLLpvaGCTVTVAQTWPAVFL 163 Pyronema omphalode...
CCJ29170   82 LGAIAAISHYLskimspvhss-vqtktirrrqAIEDLLMSFTCPIIMICLHYVIQSARYVINgvnGCVPWSDQSWPTVII 160 Pneumocystis jirov...
ETI23274   87 GGAIASIFRQIsiilhpthiavaptprqrqitLVIESILCIVLPVYVMVGHYLTQRTRYWVRlssGCIATFDINYAAPFL 166 Cladophialophora c...
AAG38536   82 LGATAAITHYLskimkpsysf-lqskitrrnqAIEDLLFSFGPPIMIMSLHYIVQPARYVIDgtsGCMPWTDRSWLAVAI 160 Pneumocystis carinii
ETN40645   87 AGADASLFRQLaaavrtdrvdlvptkgqryrkWTFDLSLCVLFPIIVMSTQYFMSNGRFYVVvviGCTPSIQSNWVAYFL 166 Cyphellophora euro...
P31397     86 PASAFTLVLYLdtvirrdh------plkryenWIWHVCLSILLPLIIMAMMVPLESNRYVVIcmnGCYSSFYQTWYTLLF 159 Schizosaccharomyce...
EPY53252   84 PASAFTLVLYLdkvirsdr------plkpfqdWVFQILLSLVFPLVIMALMVPMESNRYVVIcmnGCMPAFYQTVYTLIF 157 Schizosaccharomyce...
EGX48668  167 INAAVMCIMLTicrlfwglsmyretkkmkrqrMMYEWGLVGLFPILLAGLHYVVQPSRYYLTpvfGCHPPIDNSWLSLII 246 Arthrobotrys oligo...
EPS42569  160 INACVFCVMITiyrmfvgvgmyreskkskrtrMLYEWTIGGLFPVILAGLHYVVQPNRYYLTpvyGCHPPIDNSWVSLII 239 Dactylellina hapto...
Feature 1                                                                                     
Q8J1P8    161 YTMWMLIWSFVGAVYATLVLFVFYKKRkdvrdilhctnsglnLTRFARLLIFCFIIILVMFPFSIYTFVqdlqqvdghys 240 Saccharomyces para...
CCX09282  164 QFIWSPIMAVVAAFYSIVVIIRVQQHRrqfseil-sgsttinKSRFWRLFGLAIVLLLILVPITFFTLFqhlkhgikpys 242 Pyronema omphalode...
CCJ29170  161 VLIWPPIFGSISAYYSAKVIYLYFKKQkefqnvlrdsktsmtLSRFVRLIGICSLLVTVYLPLNIYMLYtnifliiqski 240 Pneumocystis jirov...
ETI23274  167 TYLWPLVVSLIGSTYCLISILRLKQHRnqmasvl-shtlgatTSRFYRLFALACTLLAIYCPLSLVSFVqdiripmhkys 245 Cladophialophora c...
AAG38536  161 VLLWPPVFGSISAYYSVKVIISYIKKRnefqtvlkdsktsmtLSRFIRLIGLSSLIITIYLPLNIYLLIaniaeiirsni 240 Pneumocystis carinii
ETN40645  167 QLGWALLSALIATVYCTIAVARVVRHRrqisgvl--atsgmrTDRYIRLFTLGAVGLALSLPHPLLAAIglwvtgstgda 244 Cyphellophora euro...
P31397    160 FYIPPCLLSFGGLFFVSRIVVLYWRRQrelqqff-qrdsqltSKRFLRLLCLAAVFFLGYFPLTIFMVVangklqqflpf 238 Schizosaccharomyce...
EPY53252  158 FYLPPCLLSLGGLFFVSRILYYYWHRQkelqqff-qrdsqltSKRFLRLLLLDAVFFLGYFPLTLYLLIvnckghkfmav 236 Schizosaccharomyce...
EGX48668  247 LGWPLLLSTAALGFTIVAFYKINKHLAertvidi-frsdsslDTSFQRLYLIGALFTLIYYPTNIYGFVqfclspmlpyd 325 Arthrobotrys oligo...
EPS42569  240 VGWPFVFSSSAAVLVFMIVHKMKKHLAernlmgf-ltsthtiDSGFRRLYMMVTLFLVIYWPTNLYGVVsfcmtpmlpyd 318 Dactylellina hapto...
Feature 1                                                             
Q8J1P8    241 fkn-----thsstiwntiikfdPGRPIYNIWLYFLMSYLVFLIFGLGSDALDMYSK 291 Saccharomyces paradoxus
CCX09282  243 wrs-----vhnhewqvieripmEGAIEFETWISPCAGILIFCFFGIGGEATRIYKG 293 Pyronema omphalodes CBS 100304
CCJ29170  241 nysw----dhvhqwghgiaylkNDKISFNLWLIPSNSIVVFIFFGMGSDAIVMYKE 292 Pneumocystis jirovecii
ETI23274  246 wpdihppdwserfilgqdtaqsERYIIVDRWAQVLTAYLAFLFFGLGQEATQMYKG 301 Cladophialophora carrionii CBS 160.54
AAG38536  241 kysw----shvhnwssiifyvsKSNMPFNRWLSPSSGIIIFIFFGMGSDAIVMYKE 292 Pneumocystis carinii
ETN40645  245 iswrkshppwwadmilrmsvdgVSEQLVTRGSQIVLGFIVFALFGLGREANLFYST 300 Cyphellophora europaea CBS 101466
P31397    239 nhe-----lveawhqesityypTTKVGLNDWVPPTVLYLMSLFFSTSGGWTEKVAL 289 Schizosaccharomyces pombe 972h-
EPY53252  237 dhy-----lmslwhrvpvdffqATSIYLNNWIPPTVLIVMSIFFITSGKWTDKVAI 287 Schizosaccharomyces cryophilus OY26
EGX48668  326 wda-----vhadwwdtiykfpdNPHFQYQRWIKVVASWILGIVFGFGPEAEKIYWD 376 Arthrobotrys oligospora ATCC 24927
EPS42569  319 wga-----vhadwwgtiykfpdNQSFQYQRWIKVIAGWALFLIFGRGAEAEFIYWD 369 Dactylellina haptotyla CBS 200.50

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