Conserved Protein Domain Family
7tmA_Anaphylatoxin_R-like

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cd14974: 7tmA_Anaphylatoxin_R-like 
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.
Statistics
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PSSM-Id: 320105
Aligned: 17 rows
Threshold Bit Score: 287.275
Created: 23-Sep-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #  ##            ###### #
Q16581        24 ILSMVILSLTFLLGLPGNGLVLWVAGLKMQrtvNTIWFLHLTLADLLCCLS-LPFSLAHLalqgqwpygrflCKLIPSII 102 human
CAG08499      39 LSLVVLNAIIFLLGFCGNALVIWIAGFKMKktvNTTWYLSLAVSDFVFCAF-LPFSIASMtmevwi-fgrvmCKLVPAVL 116 spotted green p...
Q9Y5Y4        33 HAAVLLHGLASLLGLVENGVILFVVGCRMRqtvVTTWVLHLALSDLLASAS-LPFFTYFLavghswelgttfCKLHSSIF 111 human
NP_001117878  38 SVETVINILISLLGLSGNAIVIWISGFKMRtsvNTTWYLSLAISDFLFCVC-LPFNIVYMvtshwp-fglvmCKLTSSAM 115 rainbow trout
Q99788        41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKktvNMVWFLNLAVADFLFNVF-LPIHITYAamdyhwvfgtamCKISNFLL 119 human
NP_001076281  49 VLLLVINMLICLLGLSGNGVVIWIAGFAMKksvNTTWYLSLAVSDFIFCAF-LPFNIAYSatsnwi-fglfmCKFTSFVM 126 zebrafish
Q49SP8        30 AIIAAALFMSFIVGTISNGLYLWMLKFKMQrtvNTLLFFHLILSYFISTLI-LPFMATSFlqdnhwafgsvlCKVFNSTL 108 black rat
EMP41307      20 LVFMVLCTLTFILGVTGNGFIIFITRCQKKktvNAMWHLNMAIAGFIFTVF-LPLMVAQValgfnwylrsvlCKITNIII 98  green seaturtle
Q9P296        36 VAPLPLYAAIFLVGVPGNAMVAWVAGKVARrrvGATWLLHLAVADLLCCLS-LPILAVPIargghwpygavgCRALPSII 114 human
EMP41299      20 HIAIGTNALVLGLGLAGNGLVIWITTVGWAgppTFPSACYLHLADLLFSAGrIPAIVQEAlrsrwp-fgralCKLHSFAR 98  green seaturtle
Feature 1        #  #                                            # #####                         
Q16581       103 VLNMFASVFLLTAISLDRCLVVFKPIWcqnhrnVGMACSICGCIWVVAFVMCIPVfvyreifttdnhnrcgykfglsssl 182 human
CAG08499     117 FLNMFSSIFLLVVISVDRLVSVLFPVWtqnhrtVKKASVVVFLAWLLAVALSVPSfifrdvvthlgrt------------ 184 spotted green p...
Q9Y5Y4       112 FLNMFASGFLLSAISLDRCLQVVRPVWaqnhrtVAAAHKVCLVLWALAVLNTVPYfvfrdtisrldgrimcyy------- 184 human
NP_001117878 116 FLNMFSSVFLLVLISVDRCVSITFPVWaqnnrtIPRASGVVVLVWALSAALTVPSlvyrqtkthga-------------- 181 rainbow trout
Q99788       120 IHNMFTSVFLLTIISSDRCISVLLPVWsqnhrsVRLAYMACMVIWVLAFFLSSPSlvfrdtanlhgkiscfnnfsl---- 195 human
NP_001076281 127 FLNMFSSIFILVIISVDRCVAVMFPVWaqnhrtIGKASVLIILAWIASAALSIPSivyrdvqnylgtn------------ 194 zebrafish
Q49SP8       109 SVSMFASVFFLSAISVDRYHLTLHPVWsqqhrtPRWASRIALRIWILATILSIPYlvfrethddhkgrikcqnn------ 182 black rat
EMP41307      99 SLSMFSSSFHLTAISADHCVTTVCPVWaqnhctVHLASLVTLSIWILAVMVSWRYhglcsdqs----------------- 161 green seaturtle
Q9P296       115 LLTMYASVLLLAALSADLCFLALGPAWwstvqrACGVQVACGAAWTLALLLTVPSaiyrrlhqehfpar----------- 183 human
EMP41299      99 YLVVFAGVFVLTLISLHRCLLVAQPVWvrnhcrPRLGCWLIAGAWFLAICFSVPYlvlrdvetrhges------------ 166 green seaturtle
Feature 1                                                                                        
Q16581       183 dypdfygdplenrslenivqppgemndrldpssfqtndhpwtvptvfqpqtfqrpsadslprgsarltsqnlysnvfkpa 262 human
CAG08499         --------------------------------------------------------------------------------     spotted green p...
Q9Y5Y4           --------------------------------------------------------------------------------     human
NP_001117878     --------------------------------------------------------------------------------     rainbow trout
Q99788           --------------------------------------------------------------------------------     human
NP_001076281     --------------------------------------------------------------------------------     zebrafish
Q49SP8           --------------------------------------------------------------------------------     black rat
EMP41307         --------------------------------------------------------------------------------     green seaturtle
Q9P296           --------------------------------------------------------------------------------     human
EMP41299         --------------------------------------------------------------------------------     green seaturtle
Feature 1                                                                              #  ### ###
Q16581       263 dvvspkipsgfpiedhetspldnsdaflsthlklfpsassnsfyeselpqgfqdyynlgqftdddqvptpLVAITITRLV 342 human
CAG08499     185 ----------------------------------------------------------scvnkytfdrysHSIVAYSRLV 206 spotted green p...
Q9Y5Y4       185 ----------------------------------------------------nvlllnpgpdrdatcnsrQVALAVSKFL 212 human
NP_001117878 182 -----------------------------------------------------------dtlcytdyqsgHKAVALSRFV 202 rainbow trout
Q99788       196 -------------------------------------------------stpgssswpthsqmdpvgysrHMVVTVTRFL 226 human
NP_001076281 195 ----------------------------------------------------------dcmnnytssrygHKVIAVSRFI 216 zebrafish
Q49SP8       183 ---------------------------------------------------yivgtnwessehqtlgqwiHAACFGRRFL 211 black rat
EMP41307     162 ---------------------------------------------------------------lllresgEAANIAIQFL 178 green seaturtle
Q9P296       184 ---------------------------------------------------------lqcvvdyggssstENAVTAIRFL 206 human
EMP41299     167 ----------------------------------------------------------fcvyrrdlrrfaEMPLRLSRFL 188 green seaturtle
Feature 1         ##                                            #  ## ##  #             ## ###  #
Q16581       343 VGFLLPSVIMIACYSFivfrmqrgrfaKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSlltdpe-tplgktLMSWDHVCI 421 human
CAG08499     207 AGFVVPFAIIIICYSIiilkl-rknrmTKSSKPFKVMSALVVAFFVCWLPYHVFIMLElnhqn---lnhnlLVIGLKVGT 282 spotted green p...
Q9Y5Y4       213 LAFLVPLAIIASSHAAvslrl-qhrgrRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEarahan-pglrplVWRGLPFVT 290 human
NP_001117878 203 CGFVIPLLIIVFCYSVifvql--rsrpMKSTKPVKVMTVLIVSFFVCWVPYHTFVLLEwnlgn---hslemLYTWLKVGS 277 rainbow trout
Q99788       227 CGFLVPVLIITACYLTivckl-qrnrlAKTKKPFKIIVTIIITFFLCWCPYHTLNLLElhhta---mpgsvFSLGLPLAT 302 human
NP_001076281 217 FGFIIPFILIILCYTViivrl-raskmAKSNKPFKIMTALILTFFLCWLPYHTFVLIEfnqtf----engiIRLGMQIGT 291 zebrafish
Q49SP8       212 LGFLLPFLVIVFCYKRvatkm-kdkglFKSSKPFKVMLTAVVSFFVCWMPYHVHSGLVltks-----qplpSQLTLGLAV 285 black rat
EMP41307     179 VGFLIPLALISICLVTlaarr-gqkrvAWSKKPLRTLLILHIIFFLCWSPYHIIAFLQtspkasspettesLETGTIFAH 257 green seaturtle
Q9P296       207 FGFLGPLVAVASCHSAll--------cWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLtvaapn-sallarALRAEPLIV 277 human
EMP41299     189 GGFLVPFAIIATSYVVltwkl-rrrswEGSRRTSALVLAVVALFFVCWLPHHILVLLSthqa-----nkevWGVALKLAN 262 green seaturtle
Feature 1          ##                      
Q16581       422 ALASANSCFNPFLYALLGk-dFRKKA 446 human
CAG08499     283 LMAAANSFLNPMLYVFMGn-dFRQKF 307 spotted green pufferfish
Q9Y5Y4       291 SLAFFNSVANPVLYVLTCp-dMLRKL 315 human
NP_001117878 278 TMAAVNSFLNPILYVLMGh-dFRQTL 302 rainbow trout
Q99788       303 ALAIANSCMNPILYVFMGq-dFKKFK 327 human
NP_001076281 292 ITAAANSFLNPVLYVFMGn-dFRKRF 316 zebrafish
Q49SP8       286 VTISFNTVVSPILYLFTGe-nFEVFK 310 black rat
EMP41307     258 GLLCFNSCFYPFFYLITRq-hFVSCR 282 green seaturtle
Q9P296       278 GLALAHSCLNPMLFLYFGraqLRRSL 303 human
EMP41299     263 ALAYLHSCLNPVLYGLVGyarSRGRR 288 green seaturtle

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