Conserved Protein Domain Family
7tmA_MrgprB

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cd15107: 7tmA_MrgprB 
mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320235
Aligned: 9 rows
Threshold Bit Score: 381.746
Created: 15-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           #  ##              ###### 
Q7TN45     31 NTLNFLIVIISVVGMAGNATVLWLLGFHMHrnaFSVYVLNLAGADFLYLCAQTVYSLECV-LQFDNSYF---YFLLTILM 106 Norway rat
Q91ZC1     28 QVMNLLSITISPVGMVLNIIVLWFLGFQICrnaFSAYILNLAVADFLFLCSHSIFSFLIV-CKLHYFLFyirQLLDTVTM 106 house mouse
Q7TN50     31 RVMILLSIIIAFFGLAGNAMVLWLLAFRMRrnvFSVYILNLAGANFLFLCTHTAFSLEKIiVLFHSVHIhipLLFYTLST 110 Norway rat
Q91ZB9     31 NTLNFLTVIIAMFGLAGNAIVLWLLAFHLPrnaFSVYVCNLACADFLQLCTQILGSLECF-LQLNRRHT---FFLTVVFM 106 house mouse
Q3KNA1     38 QAMILLSIIISLVGMGLNAIVLWFLGIRMHtnaFTVYILNLAMADFLYLCSQFVICLLIAfYIFYSIDInipLVLYVVPI 117 house mouse
Q3UG50     43 CTMVFLSLIVALVGLVGNATVLWFLGFQMRrnaFSVYILNLAGADFLFICFQIGYCFHMI-LDIDSIPIeidLFYLVVLN 121 house mouse
Q91ZC0     30 NTLNFLTVIIAVVGLAGNGIVLWLLAFHLHrnaFSVYVLNLAGADFLYLFTQVVHSLECV-LQLDNNSF---YILLIVTM 105 house mouse
Q3UG61     43 RTMTFLSLIIALVGLVGNATVLWFLGFQMSrnaFSVYILNLAGADFVFMCFQIVHCFYII-LDIYFIPTnffSSYTMVLN 121 house mouse
Q7TN51     30 LAMSLLSIIIAIIGLTGNVIVLQLLGFHMHrnaFSVYIFNLSGANFLFLCTHIVFSLENLiRQFHYIDIhmaLFSVNVTI 109 house mouse
Feature 1     ##  #                                          # #####                      #  #
Q7TN45    107 FNYLAGFCMIAAISTERCLSVTWPIWYHCQRpRHTSATVCALFWAFSLLLSLLLGQGCGflfskfDYSFCrycNFIATAF 186 Norway rat
Q91ZC1    107 FAYVFGLSITTIISIECCLSIMWPIWYHCQRpRHTSAVICVLLWALSLLFPALQMEKCSvlfntfEYSWCgiiNIISGAW 186 house mouse
Q7TN50    111 LAYLAGVSMVTAISAEYWLSGIWPYWYQGQRlKHTTTVICTGLWGLALLLSLLEGKSCGflgstyNQDVCwklDFIIVAW 190 Norway rat
Q91ZB9    107 FAYLAGLCMIAAISVERSLSVMWPIWYHCQRpRHTSSIMCALLWAFCLLLNFLLGEGCGllfsdpKYYFCitcALITTAL 186 house mouse
Q3KNA1    118 FAYLSGLSILSTISIERCLSVIWPIWYRCKRpRHTSAITCFVLWVMSLLLGLLEGKACGllfnsfDSYWCetfDVITNIW 197 house mouse
Q3UG50    122 FPYFCGLSILSAISIERCLSVMWPIWYHCQRpRHTSAVICTLLWVLSLVCSLLEGKECGflyytsDPGWCktfDLITATW 201 house mouse
Q91ZC0    106 FAYLAGLCMIAAISAERCLSVMWPIWYHCQRpRHTSAIMCALVWVSSLLLSLVVGLGCGflfsyyDYYFCitlNFITAAF 185 house mouse
Q3UG61    122 IAYLSGLSILTVISTERFLSVMWPIWYRCQRpRHTSAVICTVLWVLSLVLSLLEGKECGflyytsGPGLCktfDLITTAW 201 house mouse
Q7TN51    110 LAYLAGVSMITAISVEYWLSVLWPTWYHAQRpKHTSTVICTLLWVFSLLLTLWNWIICKvldyiyNWDMCwklALIIVVW 189 house mouse
Feature 1     ## ### ##                                    #  ## ##  #           ## ###  #  ##
Q7TN45    187 LIVIFMVLFVSSLALLAKIICGShrIPVTRFYVTIALTVLVFIFFGLPIGICVFLLpwih----mmlSSFFYEMVTLLSC 262 Norway rat
Q91ZC1    187 LVVLFVVLCGFSLILLLRISCGSqqIPVTRLNVTIALRVLLLLIFGIPFGIFWIVDkwnee-nffvrACGFSHHILYVYC 265 house mouse
Q7TN50    191 LLVLFAVLSRSIQVLLVRIFCGSqrTPVTKLHVTIVLTALVLVICGFPFGIIFYLLywttevyyimpCNSFHETILLLSY 270 Norway rat
Q91ZB9    187 IILLTVVPSVSSLALLVKMICGShrIPVTRFYVTIALTLVVFIFLGLPFGIYSSFLimfke-fqsifSYHVLEVTIFLSC 265 house mouse
Q3KNA1    198 SVVFFGVLCGSSLTLLVRIFCGSqrIPMTRLYVTITLTVLVFLIFGLPFGIYWILYqwisn-fyyveICNFYLEILFLSC 276 house mouse
Q3UG50    202 LIVLFVALLGSSLALVITIFWGLhkIPVTRLYVAIVFTVLVFLLFGLPYGIYWFLLvwiek-fyyvlPCSIYPVTVFLSC 280 house mouse
Q91ZC0    186 LIVLSVVLSVSSLALLVKIVWGShrIPVTRFFVTIALTVVVFIYFGMPFGICWFLLsrime-fdsifFNNVYEIIEFLSC 264 house mouse
Q3UG61    202 LIVLFVVLLGSSLALVLTIFCGLhkVPVTRLYVTIVFTVLVFLIFGLPYGIYWFLLewire-fhdnkPCGFRNVTIFLSC 280 house mouse
Q7TN51    190 LLVLFVVLSRSNQALLFRVFCGSqqTPVTRLLVTIMLTALVVLICGFGIGICFFYWkkeen--simpCGYFYETILLLSG 267 house mouse
Feature 1                                           
Q7TN45    263 VNSCANPIIYFFVGSIRHHRLqrqtLKLLLQRAMQDTP 300 Norway rat
Q91ZC1    266 INICVNATIYFLVGSIRHGKFqkmtLKLILQRAIQGTP 303 house mouse
Q7TN50    271 INSCANPIICLLVGSIRHCRFqcgtLRLLLHRAMQDIP 308 Norway rat
Q91ZB9    266 VNSCANPIIYFLVGSIRQHRLqwqsLKLLLQRAMQDTP 303 house mouse
Q3KNA1    277 VNSCMNPIIYFLVGSIRHRRFrrktLKLLLQRAMQDTP 314 house mouse
Q3UG50    281 VNSSAKPIIYCLVGSIRHHRFqrktLKLFLQRAMQDTP 318 house mouse
Q91ZC0    265 VNSCANPIIYFLVGSIRQHRLrwqsLKLLLQRAMQDTP 302 house mouse
Q3UG61    281 INSCANPIIYFLVGSIRHHRFqrktLKLLLQRAMQDSP 318 house mouse
Q7TN51    268 VNSCANPIICLFVGSIKHCQFqcgtLRLILQRAIQESP 305 house mouse

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