Conserved Protein Domain Family
7tmA_CXCR6

?
cd15173: 7tmA_CXCR6 
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
?
PSSM-Id: 320301
View PSSM: cd15173
Aligned: 5 rows
Threshold Bit Score: 376.419
Threshold Setting Gi: 632965697
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                #  #               #  ## 
O00574        32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKlqsLTDVFLVNLPLADLVFVCTLPFWAYAGiheWVFGqvMCKSLLGIYTI 111 human
AAI57472      47 YILPVLYSVTCVTGLVGNLLIIIIYAFYEKmrtLTDTFMVNLAMADIFFLCTLPFLAYQVaqgWIFGevMCKITRVVYRI 126 African clawed ...
XP_007064392  30 IFLPCMYAFAFAFGLIGNSLILIIYIFCEKlktLTDVFLVSLATADLLFLSTLPFWAYSAareWIFGslMCKIIRGLYTL 109 green sea turtle
XP_006004158  34 YFLPWAYSIIFITGLLGNCLVIFTYIYHMKlrtLTDIYLVNLSVADVLFVSTLPFWAYSAaheWVFGrlMCKLTNGLYTI 113 coelacanth
XP_007899020  38 FFIPLFYSIMCVTGLLGNSLVIVIYVFYEKlktVTNIYMVNLAVADLLFLCTLPFWAVNAchgWIFDtfMCKVMNGAYTV 117 elephant shark
Feature 1                                                                             ######     
O00574       112 NFYTSMLILTCITVDRFIVVVKatKAYNQQAKrmTWGKVTSLLIWVISLLVSLPQIIYgnvfn-ldklICGYHDEa---- 186 human
AAI57472     127 NLYCSMLLLTCITFDRFISITQakKFNMYHSKkhSLGKLVCMIVWLVSLLLAVPQFKYsvt----sneNCFEVYDpp--- 199 African clawed ...
XP_007064392 110 NLYTSMLTLTCITIDRFIAIAQatKAHMCQAKrmVWGKVICILVWVISLAFATPQFKYstqsn-ydksVCHAVYPsd--- 185 green sea turtle
XP_006004158 114 NLYSCMLTLVCICVDRYIAIAQatKSHTFHNKklLFGKLTCFGVWVFAIILSIPELMFskvln-lsskYCRMSFPpdtki 192 coelacanth
XP_007899020 118 NFYSCMLILTCVSINRYNVIVQatKMLNCKYR--RCHSVVCTAVWLLAIILSLPQFIFseartdssskICSMVYPtnlsv 195 elephant shark
Feature 1          #  ##                                                      #      #  #        
O00574       187 -iSTVVLATQMTLGFFLPLLTMIVCYSVIIKTLlhaggFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHwey----- 260 human
AAI57472     200 hlEVMVNSFQITVGVFLPLAAMIFCYTFIIKKLifasnYQKHKSIKIIFMVVMAFIATQLPYNIGILCHVVY-------- 271 African clawed ...
XP_007064392 186 ltELVFKVLQMTLGFFIPMLTMIICYSIIIKTLlrarsFQKHKSLKIIFSIVVTFILTQLPYNLLILIRNIHvef----- 260 green sea turtle
XP_006004158 193 eiEKITIFSQLTVGFLFPFLAMVICYSVIIKTLlnakgVQRHKSLRIIFVVVAIFIILQLPYNIMKLKKMAGhhdae--n 270 coelacanth
XP_007899020 196 aiKVQVNIIQMTVGFLIPFAAMVICYSIIAKTLlhgkgFQKHKSLRIIFVIVIVFVFCQLPFNIVKLMETLSiinnvsik 275 elephant shark
Feature 1           #   #  ##  #                         
O00574       261 -yaMTSFHYTIMVTEAIAYLRACLNPVLYAFVSlKFRKNF 299 human
AAI57472     272 ---KTFDKTFMLITEAIAYMHACLNPILYFFVGvKFRKNF 308 African clawed frog
XP_007064392 261 -nlDYNFDSAVVITEAIAYLHGCLNPVLYFFIGvKFRKNF 299 green sea turtle
XP_006004158 271 cdtQVNFKYADLIAEAIAYSHCCFNPFLYAFIGeKFRKHF 310 coelacanth
XP_007899020 276 ctdSIKVDYAIIVTKCIAYVHCCLNPILYVFFGvKFKKYI 315 elephant shark

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap