Conserved Protein Domain Family
7tmA_prokineticin-R

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cd15204: 7tmA_prokineticin-R 
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.
Statistics
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PSSM-Id: 320332
View PSSM: cd15204
Aligned: 19 rows
Threshold Bit Score: 397.802
Threshold Setting Gi: 229270983
Created: 26-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #  ##              #####
ACM69153    67 IVIGVALVGIMLVCGIGNFIFIAALARYKKlrnlTNLLIANLAISDFIVAIVCCPFEMDYYvvr-qlsWEHGhvlCASVN 145  chicken
EEN51457    62 WVLGALYLVIMLVCGVGNALLLAVLARFREarttTNLLIGNLALSDWLVAVFRLPFAFDYYvvr-srsWQFGdfmCGAVN 140  Florida lancelet
EEN50577    74 IAIGVLYSLIMLVCGVGNFLLLLVLLLYKEtrttTNLLIGNLALSDLLVSLLCLPYNMDYHvvh-agsWRHStalCAVVN 152  Florida lancelet
EEN55264    17 AALGVVYSLIIMVCGVGNTLLLLVLFKYKKtrntANLLIANLALSDLIVAVCCIPFDMDYYvvr-prvWAHGnaaCAIVN 95   Florida lancelet
EEN65041    62 VILGIVYCLIMLVCGTGNSLLITAVCRFRElrcvANVLVANLALSDLLVAVFCLPFQLDYYivk-nesWGYGdfmCATVN 140  Florida lancelet
EEN62352   708 VALGAVYILIIVVCGVGNFVFLAIVGRYKKartkTNLLIANLALSDFVVAILCIPFSLDYYvin-drdWRYGrevCTLVN 786  Florida lancelet
EEN65239   660 VFLGIVYCLIVMTCGFGNLLLISVIVWFKKartmTNTLIANLALSDFLVAVFCLPFNLDYYiik-srmWTHShvtCVAVH 738  Florida lancelet
EEN68962    54 IFLALVYILIICVCGVGNLLLLIVIAAYKKmrtiTNALIANLAFSDFIVAVVCMPLIMDYYivrpdryWTYSdttCTVIN 133  Florida lancelet
EEN63675    41 IFLCTVYSITMLTCGVGNLLLMVVIAKYKEmrtiTNALVANLALSDFLVAVFCVPFILDYHivrpnrpWTYGdvtCAVVN 120  Florida lancelet
EEN41927     5 IFVGTIYVATIVTCGIGNILLMATIIMYKKmrtvTNALIANLAFSDFIVSVVCVPFIIDYYvvraerpWFYGdtiCAVIN 84   Florida lancelet
Feature 1      # ##  #                                           # #####                       
ACM69153   146 YLRTVSLYVSTNALLAIAVDRYLAIVHPlkpr-mnyQTATILIALVWIVSILVAIPSAYFatetvlfivknqekiFCGQI 224  chicken
EEN51457   141 YLNSVSLYVSTHALLVIALDRFMVVKQSgslr-vtrRRLIPIFSAVWLSAILLAIPSAVFsktaef----lngdiFCAVS 215  Florida lancelet
EEN50577   153 FFTSVSHYVSTHALLAIGVDRYLVVQNArt----rrFNPCWTSVVIWVTALVLALPGAIFsrtvpy---qrqdsvFCGVL 225  Florida lancelet
EEN55264    96 FVKTVSMYVSTNALLVIALDRYIVLYHPqrr--mgsVLSLVAVGLVWGVSLLVSVPTALYsvtisa---vggdgaICVQM 170  Florida lancelet
EEN65041   141 YVRTMSLYVSTNVLVAIAIDRYYIVVHRpmq---qrRRAWVMIIPVWLTSMIFALPSAVNsktmmn---hrnstvFCGQA 214  Florida lancelet
EEN62352   787 YVKMVSLHVSTNALVVIGIDRYITIVRHrwrr-lgkTSAILVSLGVWIASFLIAIPSAKFsmvqsg---fhrnnaFCGVV 862  Florida lancelet
EEN65239   739 FLRQTSLYVSTNALLVIAIDRYLVIMLPhipr-msaRVAGAAVTMVWVVSLLVSIPAAMStkvvpy---anngntFCGQI 814  Florida lancelet
EEN68962   134 YLRMASLYVSTNSLLVIAIDRYVVIVCTsvar-mspRVAFIVTALVWVVSMLLAIPVAIYseaveh---anggsaFCGQV 209  Florida lancelet
EEN63675   121 YARMSSLYVSTNALLVIAVDRYVVIMMPhipr-msrAVATCVVLAVWVCSMLVAIPTAVYsralyy---vdfhgtICGLV 196  Florida lancelet
EEN41927    85 YLRMASLYVSTNSLLLIAVHRSVSFSISgtrpnkkkRNPSHVILLVWLVSLLLAVPAAVYsrafpy---tatgsnFCGQI 161  Florida lancelet
Feature 1              #  ### ### ##                                                        #  
ACM69153   225 WPVdqqmyYKSYFLFIFGIEFVAPVITMTLCYARISRELwfktvpgfq-teqirkrlRCRRKTVMVLMCILTAYVLCWAP 303  chicken
EEN51457   216 YPIwhrrlYQGFTLILFAGEYVLPVCLMCACYAYIGYRVcnrrfpghr-nqsqdrsrRRSRRKTVRLVVLVAAFIVCWGP 294  Florida lancelet
EEN50577   226 WPVslqqvYKGFHIFLVVGEFAIPAVVMSVFYSVVVYKVwrrqfpgqr-nasharvqARSRRKSIRLFALFIMFVLCWTP 304  Florida lancelet
EEN55264   171 WPIrqyraSRAYFLFTIVGEFALPVLVMGVCCVLVVRKVwqrilpgqr-tdaqrrllARSRRKVVQLAVKFFMFVVCWGP 249  Florida lancelet
EEN65041   215 WSVrstkyYQAYYVMMFIIEYLVPIITMTYCHLTLWLKVhrrscpgnt-nerqqqtlARSRRKTVTLVILSSLFVLCWGP 293  Florida lancelet
EEN62352   863 WNAkhlavYRGYYGGMLAFQFVLPVVVMAVCSLPVVWKVfhrelpgnl-teamrekvQRSKRKTLRLILILALFVLCWAP 941  Florida lancelet
EEN65239   815 WPIqeearYKAYYLSMLVLEFLIPVIIMTFCYVFIVRKIwkrqvpgfrtdeqnqsimRSKRRSVRLLVVVLVLFVLCWGP 894  Florida lancelet
EEN68962   210 WPVhvenmYKAYYLTLFILQFALPVLIMGFCYIRIGLRIwyrtvpghqtdeqqmriqQSKRRVVRLLMVIVVIFTLSWFP 289  Florida lancelet
EEN63675   197 WPIghqvrYKAYYVAVLLLEFIIPVLIMSFCYIRIARRIwyrtvpgqqtesqqaamlKSKKRNVRLLIVILVMFVLCWGP 276  Florida lancelet
EEN41927   162 WPArlepmYKAYYMLLFLLEFVLPVIIMCFCYIRIALHIwyrpqtgqv-ghlpperqHHREKVIQLLIVTLLCFIVCWLP 240  Florida lancelet
Feature 1      ## ##  #              ## ###  #  ##                     
ACM69153   304 FYGFTIVRDFfptif--vkekhYLTAFYIVECIAMSNSMINTMCFVTVKnNTMKYF 357  chicken
EEN51457   295 MYSFTIIRDFsydli--shvshSTAIVYVLDGLAMSNSVISTVVYVFANdNVMKHV 348  Florida lancelet
EEN50577   305 YHVYSILRDFyigvl--akistSLNLFYMVQAIAMGNSLMNTLVYVVFNdNITRYV 358  Florida lancelet
EEN55264   250 YHGVIVARDFfpsssiatgapgTFNIFYIVEAVAMSNSVINTLVYVGFNtSVMAQL 305  Florida lancelet
EEN65041   294 YQGYTLARDLsplll---keklNTAIFYAVEALAMGNNVVNTVLYVALNaKIRKYI 346  Florida lancelet
EEN62352   942 YYVYAALRDFhhvlt---lsalNTNIFYAVEAAAMGNSVINTCVYVAFNtNVTNFL 994  Florida lancelet
EEN65239   895 YHGYSVARDYfpysl--sknklNLPIFYVVEALAMGNSMINTVVYIAMNdSIKKYI 948  Florida lancelet
EEN68962   290 YYIYAIIRDWfpeil--hdthhNTTIYFIVEALGMSNSMVNTIVYIVMNkSARKHI 343  Florida lancelet
EEN63675   277 YYGYAVVRDFfprll--aksrlNITLHYIVEAVAMGNSSIDTVVYIAMNgNVRKFM 330  Florida lancelet
EEN41927   241 YHVYAIVRDFaphll--lvsryNTTLFFIVEALGMAQGMVNTIIYIGMNsAVRQHM 294  Florida lancelet

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