Conserved Protein Domain Family
7tmA_OXR

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cd15208: 7tmA_OXR 
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.
Statistics
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PSSM-Id: 320336
View PSSM: cd15208
Aligned: 13 rows
Threshold Bit Score: 413.324
Threshold Setting Gi: 405975375
Created: 29-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
BAD72879      57 WALIAGYIVVFIVALVGNVLVCIAVWKNHHMRtvTNYFIVNLSLADILVTITCLPATLVVDItetWFFGhhlCKAIPYLQ 136 chicken
NP_001073337  55 WVLIAGYILVFLVSLVGNTLVCFAVWKNHHMRtvTNYFIVNLSFADILVTITCLPASLVVDItetWFFGqtlCKILPYLQ 134 zebrafish
O43614        55 WVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRtvTNYFIVNLSLADVLVTITCLPATLVVDItetWFFGqslCKVIPYLQ 134 human
O43613        47 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRtvTNYFIVNLSLADVLVTAICLPASLLVDItesWLFGhalCKVIPYLQ 126 human
ADT91713      53 WVLIVGYIIVFIIALIGNILVCVAVWKNHHMRtvTNYFIVNLSLADVLVTIICLPATLLVDItetWFFGktlCKVIPYLQ 132 African clawed ...
ACY92610      54 WVLISAYFLVFILALGGNVLVCYAVLRNPQMRtvTNYYILNLSIADILVSLICLPITVVFETsetWFFGnlaCKLIPYFQ 133 Saccoglossus ko...
NP_001127714  73 WILIATHTFVFITGLFGNALVCVAVYRNHSMRtvTNYFIVNLAVADFMVILFCLPATVLWDVtetWFLGeglCKVLPYFQ 152 domestic silkworm
ELU16138      65 WCLIVLYLIVFTLGLVGNFLVVFVVVRNKHMRtiTNLFIVNLSVADFLVLLICLPASVLTDVtetWFMGrvmCKLVHYLQ 144 Capitella sp. I...
ELU18833      32 WILILLYGMIFVIGLVGNFLVCFAVWRNPSMRtvTNYFIVNLALADFLVILICLPSTVIEDVamtWFFGrimCKIVKYLQ 111 Capitella sp. I...
EKC31663      50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRtvTNIFIVNLAIADLAVIIICLPPTLLSDVtetWYFGfamCKIALFLQ 129 Pacific oyster
EKC39941      35 WILIGLFVVVFLLGISGNLLVCLAVWRNRNLRtlTNVHLVNLAVADFMVIAVCLPPTLLHDAlesWFLGtvgCKIVTYLQ 114 Pacific oyster
XP_006007993  91 WALIAGYIIVFIVALFGNILVCVAVWKNHHMRtvTNYFIVNLSLADVLVTITCLPASLVVDItetWFFGqtlCKVIPYLQ 170 coelacanth
XP_007892276  57 WVLIAAYIAVFVVALVGNVLVCVAVWKNHHMRtvTNYFIVNLSFADVLVTIICLPASLVVDItetWFFGqifCKVIPYLQ 136 elephant shark
Feature 1        #  #                                          # #####                           
BAD72879     137 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCIIMIPQAIVMecssvfpglankttlFTVCDehw 216 chicken
NP_001073337 135 TISVSVSVLTLSCIAQDRWYAICHPlkFKSTAkRARKSIVLIWLVSCIMMIPQAVVMessslmpeltnktslFTVCDeqw 214 zebrafish
O43614       135 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIVIIWIVSCIIMIPQAIVMecstvfpglankttlFTVCDerw 214 human
O43613       127 AVSVSVAVLTLSFIALDRWYAICHPllFKSTArRARGSILGIWAVSLAIMVPQAAVMecssvlpelanrtrlFSVCDerw 206 human
ADT91713     133 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRAQQSIVIIWIVSCVIMIPQAIVMecrsvfpelanktilFTVCDerw 212 African clawed ...
ACY92610     134 VVSMSVSVLTLCAIAVDRYFAICHPlmFKSTAkRAITVIFSIWITSFLVPIPQAVVYeterpiy--tknyiyLTKCFern 211 Saccoglossus ko...
NP_001127714 153 SVSVTVSVLTLTFISVDRWYAICFPlkFKSTTgRAKTAILIIWLVSLCFNIPELVVLklvrfvp-lrfelpyLLQCYgtw 231 domestic silkworm
ELU16138     145 AVSVSVSVLTLTVISIERYYAICHPlsFKSTHtRARLMIILVWVISLAIVIPELVILdlfphk----pytdlLMACKpsw 220 Capitella sp. I...
ELU18833     112 AVSVAVSVFTLSCISLERFYAICYPlsFKSTPrRAKVMIVVTWVLALLMAIPDLICLdtqhnsg-lpadfslLTTCKptw 190 Capitella sp. I...
EKC31663     130 TTSVAVSVFTLSAISVERWYAICYPlrFKSTKrRAKIIILVIWIIAFLLALPEVIVAdltrfvk--rqyidlLIFCGpqw 207 Pacific oyster
EKC39941     115 KVSVLVSVLTLTTIGIERYLGICHPmsDFLPRiKTRVALLGIWVVAMVTAIPDAYYMtvipdnv-ipptinlLKSCRpsd 193 Pacific oyster
XP_006007993 171 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCVIMIPQAIVMecsnlvpelanktnlFTVCDeqw 250 coelacanth
XP_007892276 137 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCVLMTPQAIVMecsimvpelvnktilFTVCDehw 216 elephant shark
Feature 1              #  ### ### ##                                                             
BAD72879     217 g-aevyPKMYHTCFFLVTYMAPLCLMVLAYLQIFRKLWcrqipgtssvvqkkwkslqssaq--qrglgqstkskisavaa 293 chicken
NP_001073337 215 p-deiyPKVYHTCFFIVTYFAPLCLMVLAYIQICHKLWcqqipgsssvlqrqwkslqcsah--avgsgesvkvrtstvsa 291 zebrafish
O43614       215 g-geiyPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWcrqipgtssvvqrkwkplqpvsq--prgpgqptksrmsavaa 291 human
O43613       207 a-ddlyPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqprarafla 285 human
ADT91713     213 e-gqiySKVYHICFFFITYMVPLCLMILAYLQIFRKLWcrqipgtssvvqrkwkplqcsi---hskgqqstksrnnavaa 288 African clawed ...
ACY92610     212 wfgsiqQKVYHIALVLVIYVIPLVMIIIAYVFICRQLWakipgsyescdskkna---------------sngnshvstka 276 Saccoglossus ko...
NP_001127714 232 s--pssELVWHILKVLLIYTLPLVLMAVAYHQIARVLWssngipgqadt-------------------------kklata 284 domestic silkworm
ELU16138     221 s--ytsQAAFQIVLIVALFFLPFCLMGFAYIRIALCLWsdfiptescecnkpl-----------------nadgksshhe 281 Capitella sp. I...
ELU18833     191 s--hsiQVGVQCFNLLVMYLLPLGFMFCTYFRIVRCLWsnniptessrdql---------------------hsngsnsa 247 Capitella sp. I...
EKC31663     208 s-dktnQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrp--------------------mmdgnvnr 266 Pacific oyster
EKC39941     194 ---sqvEVTQQLVIFFVFFIIPLAIMGFAYTNIFLCLWrstqslpnin----------------------------neha 242 Pacific oyster
XP_006007993 251 g-deiyPKVYHICFFLVTYMAPLCLMILAYLQIFHKLWcrqipgtssvvqrkwkplqcslq--prgsgfknkpkvnavaa 327 coelacanth
XP_007892276 217 g-dtvyPKVYHICFFIVTYMGPLCLMILAYFQIFRKLWcrqipgtssvvqrkwkplalqcs-sqraaglqtkprinavaa 294 elephant shark
Feature 1                                 #  ## ##  #               ## ###  #  ##                
BAD72879     294 eikqiRARRKTARMLMVVLLVFALCYLPISILNILKrvfgmfn-haddretVYAWFTFSHWLVYANSAANPIIYNFLSgk 372 chicken
NP_001073337 292 eakqvKARRKTARMLMVVLFVFALCYLPISILNIMKrvfgafk-ntgnretVYAWFTFSHWLIYANSAANPIIYNFLSgk 370 zebrafish
O43614       292 eikqiRARRKTARMLMIVLLVFAICYLPISILNVLKrvfgmfa-htedretVYAWFTFSHWLVYANSAANPIIYNFLSgk 370 human
O43613       286 evkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgmfr-qasdreaVYACFTFSHWLVYANSAANPIIYNFLSgk 364 human
ADT91713     289 eikqiHTRRKTARMLMVVLLVFALCYLPISILNILKrvfgmft-htndretVYAWFTFSHWLVYANSAANPIIYNFLSgk 367 African clawed ...
ACY92610     277 sesqlKSRRKVAKMLIIVVVIFTICYLPLHLLNILRqfsffddvvhntrssFHIPFLIAHWLAFANSGVNPIIYNFLSak 356 Saccoglossus ko...
NP_001127714 285 eltqlRSRRKAAKMLVSVVIMFAVCYFPVHLLSVMRytidm-----gqtefITIWALVSHVMCYANSAINPLIYNLMSdk 359 domestic silkworm
ELU16138     282 vrqqvTSRRNVAKMLIAVVIMFGICYLPVHLLNILRyakal-----mngvaAVNFALIAHWLCYFNSAINPLIYNFMSak 356 Capitella sp. I...
ELU18833     248 aenqlRGRRNAAKMLIAVVVMFCICYLPVHLLNILGyanald----ligdyITLLALMSHWLSYLNSAINPVIYNYMSmp 323 Capitella sp. I...
EKC31663     267 aeeqlESRKKAAKMLITVVIGFAVCYFPVHLFNILRyadalr---fvaprmIQVLSMISHWLPYLNSSINPIIYNFMSvq 343 Pacific oyster
EKC39941     243 antviQNRKITAKMLIVVVAAFFACNLPVYILNILRyvgvlf---tvdhakIKSFALSSHLLLYTSSAINPVIYTIMSgh 319 Pacific oyster
XP_006007993 328 eikqiHARRKTARMLMVVLFIFALCYLPISILNILKrvfgmfk-ssndretVYAWFTFSHWLVYANSAANPIIYNFLSgk 406 coelacanth
XP_007892276 295 eikqiRARRKTARMLMVVLFFFAVCYLPISILNVLKrvfgmfd-niddratVYAWFMFSHWLVYANSAANPIIYNFLSgk 373 elephant shark
Feature 1             
BAD72879     373 FREEF 377 chicken
NP_001073337 371 FREEF 375 zebrafish
O43614       371 FREEF 375 human
O43613       365 FREQF 369 human
ADT91713     368 FREEF 372 African clawed frog
ACY92610     357 FRREF 361 Saccoglossus kowalevskii
NP_001127714 360 FRREF 364 domestic silkworm
ELU16138     357 FRKEF 361 Capitella sp. I Grassle & Grassle, 1976
ELU18833     324 IAPSA 328 Capitella sp. I Grassle & Grassle, 1976
EKC31663     344 TKGAF 348 Pacific oyster
EKC39941     320 SQTTD 324 Pacific oyster
XP_006007993 407 FREEF 411 coelacanth
XP_007892276 374 FREEF 378 elephant shark

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