Conserved Protein Domain Family
7tmA_SREB2_GPR85

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cd15218: 7tmA_SREB2_GPR85 
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320346
View PSSM: cd15218
Aligned: 4 rows
Threshold Bit Score: 581.606
Threshold Setting Gi: 15214045
Created: 28-Mar-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##            ###### 
P60895        21 FLKLTSLGFIIGVSVVGNLLISILLVKDKTLHraPYYFLLDLCCSDILRSAICFPFVFNSVKNgstWTYGtltCKVIAFL 100 horse
Q9I919        22 FLKLTSLGFIIGVGVVGNLLISILLVKDKSLHraPYYFLLDLCASDILRSAICFPFVFTSVKNgsaWTYGtltCKVIAFL 101 zebrafish
NP_001088479  21 FLKLTSLGFIIGVSVVGNLLISILLVKDKTLHraPYYFLLDLCCSDILRSAICFPFVFTSVKNgstWTYGaltCKVIAFL 100 African clawed ...
EMC76885      21 FLKLTSLGFIIGVSVVGNLLISILLVKDKTLHraPYYFLLDLCCSDILRSAICFPFVFTSVKNgstWTYGtltCKVIAFL 100 Ficedula albico...
Feature 1        ##  #                                            # #####                      # 
P60895       101 GVLSCFHTAFMLFCISVTRYLAIAhhrFYTKRLtfWTCLAVICMVWTLSVAMAFPPVLDvgtysFIREEDQCTFQHRsFR 180 horse
Q9I919       102 GVLSCFHTAFMLFCVSVTRYLAIAhhrFYTKRLtfWTCLAVICMVWTLSVAMAFPPVLDvgtysFIREEDQCTFQHRsFR 181 zebrafish
NP_001088479 101 GVLSCFHTAFMLFCISVTRYLAIAhhrFYTKRLtfWTCLAVICMVWTLSVAMAFPPVLDvgtysFIREEDQCTFQHRsFR 180 African clawed ...
EMC76885     101 GVLSCFHTAFMLFCISVTRYLAIAhhrFYTKRLtfWTCLAVICMVWTLSVAMAFPPVLDvgtysFIREEDQCTFQHRsFR 180 Ficedula albico...
Feature 1         ### ### ##                                                                     
P60895       181 ANDSLGFMLLLALILLATQLVYLKLIFFvhdrRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIR 260 horse
Q9I919       182 ANDSLGFMLLLALILLATQLVYLKLIFFvhdrRKMKPVQFVPAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIR 261 zebrafish
NP_001088479 181 ANDSLGFMLLLALILLATQLVYLKLIFFvhdrRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIR 260 African clawed ...
EMC76885     181 ANDSLGFMLLLALILLATQLVYLKLIFFvhdrRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIR 260 Ficedula albico...
Feature 1                                             #  ## ##  #        ## ###  #  ##           
P60895       261 qnanttgRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFargpvvPGGFLTAAVWMSFAQAGINPFVCI 340 horse
Q9I919       262 qnsnaagRRRLLVLDEFKTEKRISRMFYIITFFFLSLWGPYLVACYWRVFargpviPGGYLTAAVWMSFAQAGVNPFICI 341 zebrafish
NP_001088479 261 qnanttgRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLIACYWRVFargpvvPGGFLTAAVWMSFAQAGINPFVCI 340 African clawed ...
EMC76885     261 qnanttgRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFargpvvPGGFLTAAVWMSFAQAGINPFVCI 340 Ficedula albico...
Feature 1                  
P60895       341 FSNRELRRCF 350 horse
Q9I919       342 FSNRELRRCF 351 zebrafish
NP_001088479 341 FSNRELRRCF 350 African clawed frog
EMC76885     341 FSNRELRRCF 350 Ficedula albicollis

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