Conserved Protein Domain Family
7tmA_GPR61_GPR62-like

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cd15220: 7tmA_GPR61_GPR62-like 
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.
Statistics
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PSSM-Id: 320348
View PSSM: cd15220
Aligned: 8 rows
Threshold Bit Score: 208.052
Threshold Setting Gi: 296434526
Created: 7-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #  ##              ######
Q9BZJ7        16 LGLILAAVVEVGALLGNGALLVVVLRTPGl--rDALYLAHLCVVDLLAAASIMPLGLLAApppglgrvrlgpapCRAARF 93  human
EEN59774      25 AMISVMTITDVLAIAGSISVMAVIAKTPQlrilTLIFVFNLCAADLMHSLSSTPLAIATLahggew--fstvpmCQMTGF 102 Florida lancelet
EMC83963       8 VGLLCMVLLTLTALVANTLVMVVILKTPLl--rKFIFVCHLCVVDLLSAIFLMPLGIISSsscfnrv-iysiaeCKGMIF 84  domestic pigeon
CAG06826      33 LALAAMLLMDLLAVVGNVAVMAVIAKAPQl--hKFAFVFHLCVVDLLAALVLMPLGMLSGraff------gealCRSYLF 104 spotted green p...
Q91178        48 FGLFCMVTLNLIALLANTGVMVAIARAPHl--kKFAFVCHLCAVDVLCAILLMPLGIISSspffgtv-vftileCQVYIF 124 Japanese medaka
XP_001342078  50 SGLVVMVTLNAIALIANSAVLAIVVKVPHl--rKFSLVCHLCIVDLLCAALLMPLGIVCGspffagv-vfsvleCRLYIF 126 zebrafish
XP_002194977  37 VGLFFMVLLDLTAIVGNAAVMTVIAKTPAl--rKFVFVFHLCLVDFLAALTLMPLEMLSGsavfesp-glgeavCRVYLF 113 zebra finch
Q9BZJ8        44 VALFFMLLLDLTAVAGNAAVMAVIAKTPAl--rKFVFVFHLCLVDLLAALTLMPLAMLSSsalfdha-lfgevaCRLYLF 120 human
Feature 1         ##  #                                            # #####                       
Q9BZJ7        94 LSAALLPACTLGVAALGLARYRLIVhplr---pgsrPPPVLVLTAVWAAAGLLGALSLLgtppapppap----------- 159 human
EEN59774     103 LDSFFTFGSISTVCVISVERYYSIVrpmvhaayltlLKALFAIGVIWLLALAFAMAPLMgwngysfnpiqk--------- 173 Florida lancelet
EMC83963      85 LNVCFISASILTISIISVERYYYIVhpmryevkmtiRLALAGMVFIWVKSVLITILAVVswplgngatsas--------- 155 domestic pigeon
CAG06826     105 LSVCLVSAAILSISVINVERYYYIVhpmryevrmtvGLVASVLVGVWVKALAMSALPLLawflqsgrtpllesggvggeg 184 spotted green p...
Q91178       125 LNVFLIWLSILTITAISVERYFYIVhpmryevkmtiNLVIGVMLLIWFKSLLLALVTLFgwppyghqssiaa-------- 196 Japanese medaka
XP_001342078 127 LNAFLVSASIFTVTVISIERYFYIVhpmryeakmtpWLSAAVMGLVWVASTLLGLATVFgwpsygsrssiaa-------- 198 zebrafish
XP_002194977 114 LSVCLTSMCILSISTINVERYYYVVhplryevrmtaGLVAGVLAGVWLKAVATSLVPVLgwlspdrpptsgt-------- 185 zebra finch
Q9BZJ8       121 LSVCFVSLAILSVSAINVERYYYVVhpmryevrmtlGLVASVLVGVWVKALAMASVPVLgrvsweegapsvp-------- 192 human
Feature 1                                #  ### ### ##                                           
Q9BZJ7       160 ---------------arcsvlaggLGPFRPLWALLAFALPALLLLGAYGGIFVVarraalrpprpargsrlh-------- 216 human
EEN59774     174 -------------ectfswseggaSTVYAIIISVVYFCIPAMVIITMYGFIYRTarkasrqvgplpapllpvdetqmpsg 240 Florida lancelet
EMC83963     156 -------------rctvywspgahKKAFVIIFSIVCFVLPTVLIFAVYCSVYRVarmaslqhvpmpaptqaaaprhrse- 221 domestic pigeon
CAG06826     185 aaalypppqghrrcslhwtgggsnRLAFMVLFTLVYFLCPLLVILVVYCNMFKVarvaamhhgplptwmdtprrqrses- 263 spotted green p...
Q91178       197 ------------shcslhashsrlRGVFAVLFCVICFLAPVVVIFSVYSAVYKVarsaalqqvpavptwadaspakdrs- 263 Japanese medaka
XP_001342078 199 ------------thcslhwshsghRRVFAILFCTVCFCVPAAIIIAVYGNVYKVahtaarergpipswtiatahpkrrsd 266 zebrafish
XP_002194977 186 ------------rgcslqwsrgpsCKVFVVFFAAFYFVLPLLIILVVYCGMFKVarvaamhhgppptwmetprrrsa--- 250 zebra finch
Q9BZJ8       193 ------------pgcslqwshsayCQLFVVVFAVLYFLLPLLLILVVYCSMFRVarvaamqhgplptwmetprqrse--- 257 human
Feature 1                                                                            #  ## ##  # 
Q9BZJ7       217 -------------------------------sdsldsrlsilpplrprLPGGKAALAPALAVGQFAACWLPYGCACLAPa 265 human
EEN59774     241 iflqvppatpsqifnvssrvgpapstsmnsltvsgaldggnllgkrqhNEPLKATKTLLLIVGLFLFTWGPYFTASFYLg 320 Florida lancelet
EMC83963     222 ------------------------siashvtiittrnlplprltserfLGSNKAIVTLVLIVGQFLCCWLPFFAFHLHSs 277 domestic pigeon
CAG06826     264 -----------------------lssrstmvtssgtgsgtgrvtpqrpFGGGKAAAVLVAVGGQFLCCWLPYFTFHLYSa 320 spotted green p...
Q91178       264 ------------------------dsinsqttiittrtlpqrlsperaFSGGKAALTLAFIVGQFLVCWLPFFIFHLQMs 319 Japanese medaka
XP_001342078 267 s---------------------vnsqttiittstsvrrnqvprrkrrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLs 325 zebrafish
XP_002194977 251 --------------------------slssrstmvttsgaprttpqriFGGGKAAAVLLAVGGQFLFCWLPYFSFQLYTa 304 zebra finch
Q9BZJ8       258 --------------------------slssrstmvtssgapqttphrtFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVa 311 human
Feature 1                ## ###  #  ##                     
Q9BZJ7       266 a------rAAEAEAAVTWVAYSAFAAHPFLYGLLQrpVRLAL 301 human
EEN59774     321 lvgvkysgVEDAVIWLRILARTSFALNSLVYGLLNrqVRLEL 362 Florida lancelet
EMC83963     278 vaa-gtvgGGHGEMVVTWIAYSSFAINPFFYGLLNrqIREEL 318 domestic pigeon
CAG06826     321 laasppaaLASMEEVVTWIGYFCFTTNPFFYGCLNrqIREEL 362 spotted green pufferfish
Q91178       320 ltg-smksPGDLEEAVNWLAYSSFAVNPSFYGLLNrqIRDEL 360 Japanese medaka
XP_001342078 326 lgi-shstSEEAEGPVTWLAYSTFAVNPFFYGLLNrqIREEL 366 zebrafish
XP_002194977 305 lst-rplaGPAAETVVTWLGFCCFTSNPFFYGCLNrqIRGEL 345 zebra finch
Q9BZJ8       312 lsa-qpisTGQVESVVTWIGYFCFTSNPFFYGCLNrqIRGEL 352 human

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