Conserved Protein Domain Family
7tmA_OR6B-like

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cd15224: 7tmA_OR6B-like 
olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320352
Aligned: 20 rows
Threshold Bit Score: 416.684
Created: 4-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##               ####
O95007        25 AAMFLIFLVAYILTVAENVIIILLVLQNRPlhkPMYFFLANLSFLETWYISVTVPKLLFSFws----vnNSISFtlCMIQ 100 human
Q60889        29 DALFAVFLTLYLLTLLENTLIIYLICSHKElhkPMYFFLGNLSCLEMCYVSVTMPTLLMGLwn----glYHIPFiaCMTQ 104 house mouse
Q8NGX8        30 LLFFSIFLATYLLTLLENLLIILAIHSDGQlhkPMYFFLSHLSFLEMWYVTVISPKMLVDFls----hdKSISFngCMTQ 105 human
NP_001000554  26 GLLFGLFLIIYVVTVLENLVIVGTISASRQlhiPMYFFLANLSVLETLYTTVTVPKLLAGLla----gaKAISFsgCLTQ 101 Norway rat
Q8NGX9        25 LLLFVLFFAIYLLTLLENALIVFTIWLAPSlhrPMYFFLGHLSFLELWYINVTIPRLLAAFlt----qdGRVSYvgCMTQ 100 human
O95222        26 VLLFALLLLAYVLVLTENTLIIMAIRNHSTlhkPMYFFLANMSFLEIWYVTVTIPKMLAGFvgskqdhgQLISFegCMTQ 105 human
XP_006274667  52 VLLFLIFIIIYVLTLAENMVIIVTVRMSIHlqtPMYFFLSNLSFLEMWYITVTMPKMLLSLlt----ssQNISFvgCMTQ 127 American alligator
XP_006034167  27 VLLFSVFLITYMLVVTENTVIILTVHRNRHlhtPMYFFLSNLSFLEIWYITVTLPKTMLNFlm----enKHISFvgCMMQ 102 Chinese alligator
XP_005141239  28 ILFFPIFLIAYLLVLAENMIIILTVWTNYNlhtPMYFFLSNLSFLEIWYVTVTVPKTILSFvs----vtKGISFmgCMTQ 103 budgerigar
EMC87206      31 VLLFSAVLLAYLLTVLENFLIILIIRTNHSlqkPMYFFLGNLSFLEICYVSVIEPKMLIDFls----qdKNISFhgCMTQ 106 rock pigeon
Feature 1        ## ##  #                                            # #####                     
O95007       101 LYFFIALMCTECVLLAAMAYDRYVAICRPlhYPTIMsHGLCFRLALGSWAIGFGISLAKiyfiscLSFCGPnVINHFFCD 180 human
Q60889       105 LFFFIVLVGTECILLASMAYDRYVAICRPlhYPVLMrPQVCLGLAMISWLGGLLVSMIKttciatLSYCGPnVLNHFFCD 184 house mouse
Q8NGX8       106 LYFFVTFVCTEYILLAIMAFDRYVAICNPlrYPVIMtNQLCGTLAGGCWFCGLMTAMIKmvfiaqLHYCGMpQINHYFCD 185 human
NP_001000554 102 LFLFLSLGSSECFLLSTMACDRYLAICRPlhYPAIMdSKLCLHLALSAWLGGFLASFVStalisrLSFCGSnALNHFFCD 181 Norway rat
Q8NGX9       101 LYFFIALACTECVLLAVMAYDRYLAICGPllYPSLMpSSLATRLAAASWGSGFFSSMMKllfisqLSYCGPnIINHFFCD 180 human
O95222       106 LYFFLGLGCTECVLLAVMAYDRYMAICYPlhYPVIVsGRLCVQMAAGSWAGGFGISMVKvflisgLSYCGPnIINHFFCD 185 human
XP_006274667 128 LYFFIALACTECVLLAVMAYDRYVAICSPlrYPAIMtHELCFRLVAGSWMGGFTSSMLKvtfisrLTFCGS-VINHFFCD 206 American alligator
XP_006034167 103 LYFFLALGCTVCVLLAVMPYDHYVAICNPlrYPAIMsRALCTHLAAGSWISGFFISMWKvllisqLTYCGPnIINHFFCD 182 Chinese alligator
XP_005141239 104 LYFFLSLGNTECLILAVMAYDRYVAICKPfhYSTIMrHTVCVYLTTGSWLTGFLISGCKvffisgLTYCGPnTINHFFCD 183 budgerigar
EMC87206     107 LYFFVTFVCTEYILLAVMAYDRFLAICKPlqYSLIMnHQFCAQLTAACWMCGLITSSIKlsfiaqLSFCGVdKINHYFCD 186 rock pigeon
Feature 1                      #  ### ### ##                                            #  ## ## 
O95007       181 ISPVLNLSCTDmsiTELVDFILALVIFLFPLFITVLSYGCILATILcm--pTGKQKAFSTCASHLVVVTIFYSAIIFMYA 258 human
Q60889       185 VSPLLNLSCTHvalTELVDFISAIVILWGCFLTTMASYVAIGRAVLrmpstTARYKAFSTCASHLVVVGIFYSVTIFIYA 264 house mouse
Q8NGX8       186 ISPLLNVSCEDasqAEMVDFFLALMVIAIPLCVVVASYAAILATILripsaQGRQKAFSTCASHLTVVILFYSMTLFTYA 265 human
NP_001000554 182 VSPLLQLSCTDttaIEMLDFVAALAVLATSLIVTSVSYVHIVATVLripggAGRRRAFSTCASHLVVVLIFYTTTTFMYA 261 Norway rat
Q8NGX9       181 ISPLLNLTCSDkeqAELVDFLLALVMILLPLLAVVSSYTAIIAAILriptsRGRHKAFSTCAAHLAVVVIYYSSTLFTYA 260 human
O95222       186 VSPLLNLSCTDmstAELTDFILAIFILLGPLSVTGASYVAITGAVMhipsaAGRYKAFSTCASHLTVVIIFYAASIFIYA 265 human
XP_006274667 207 ISPLLNLACTDmslAELVDFILALIMILMPLLVVVASYLCIAAAVAqiptaQGRRKAFSTCASHLAVVVIFYSTTLFTYA 286 American alligator
XP_006034167 183 VSPLLTLACTDmslAELTDFILVLFILLIPLCVTIFSYIYIISTIVhipsaHGRQKAFSTCASHLTVVIIFYAASIFIYA 262 Chinese alligator
XP_005141239 184 VSPLLNLACTDlerAALMDFVAALFILLIPLSVVILSYTYIIFTVLhissvQDRQKAFSTCASHLIVVTVFYATSIFIYV 263 budgerigar
EMC87206     187 ISPLLNISCSDsslAELVDFVLALIVIMVPLCTVVTSYICIIFTMLkipssRGRQKAFSTCSSHLTVVILFYSTTLFTYA 266 rock pigeon
Feature 1         #     ## ###  #  ##              
O95007       259 RPrvihAFNMNKIISIFYAIVTPSLNPFIYCLRN 292 human
Q60889       265 RPkrieAMDLNKVLSVIYTVVTPMCNPVIYCLRN 298 house mouse
Q8NGX8       266 RPklmyAYNSNKVVSVLYTVIVPLLNPIIYCLRN 299 human
NP_001000554 262 RPhaisSFDLNKLVSVIYSVVTPLLNPIIYCLRN 295 Norway rat
Q8NGX9       261 RPramyTFNHNKIISVLYTIIVPFFNPAIYCLRN 294 human
O95222       266 RPkalsAFDTNKLVSVLYAVIVPLLNPIIYCLRN 299 human
XP_006274667 287 RPramlAFDSNKLVSVLYTIVVPLFNPIIYCLRN 320 American alligator
XP_006034167 263 RPkaisSLNSNKLISVLYTVIVPLFNPIIYCLRN 296 Chinese alligator
XP_005141239 264 RPktlpVNDTNKIVSAFYAVVVPLFNPIIYCLRN 297 budgerigar
EMC87206     267 HPkvmyTYHANKLVSVLYTVVVPLLNPLIYCLRN 300 rock pigeon

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